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Postdoctoral Positions at HMS


Biological Chemistry and Molecular Pharmacology | Biomedical Informatics | Cell Biology | Center for Bioethics | Genetics | Global Health and Social Medicine | Harvard Catalyst | Health Care Policy | Microbiology and Immunobiology | Neurobiology | Systems Biology | Harvard School of Dental Medicine | Wyss Institute


This page lists some of the postdoctoral positions currently available on the HMS Quadrangle. Many principal investigators do not advertise their postdoctoral positions with us, so if the PI you want to work with isn't listed here, please contact her/him directly. Please do not send your CV to the administrator of this page.

Quad Departments: to have an opportunity listed on this page, send along a description of the postdoctoral position and contact information to us at postdoc_office@hms.harvard.edu.

Postdoc openings at other Harvard affiliated institutions:
Beth Israel Deaconess Medical Center | Brigham & Women's Hospital | Children’s Hospital | Dana-Farber | Joslin | Mass General Hospital * | McLean Hospital* | T.H. Chan School of Public Health*
*Please note: some Harvard affiliates do not advertise individual postdoc positions with us, it may be best to identify a PI conducting work in your specific area of interest, and to email that PI directly with your CV and cover letter.

 


~FEATURED FELLOWSHIP OPPORTUNITIES~

 

The Laboratory of Systems Pharmacology at Harvard Medical School

Project Coordinator and Data Scientist in the HMS LSP
The Laboratory of Systems Pharmacology (LSP) at HMS seeks an individual to serve as a project coordinator and data scientist for a recently developed large-scale model of the Ras oncogene pathway. This DARPA-funded computational model, the Ras Executable Model (REM; http://rasmodel.org), is being developed in collaboration with the National Cancer Institute as a first-in-kind attempt to integrate data on protein structure, biochemical activity, oncogenic mutation and genetic interaction for the purpose of accelerating fundamental understanding of signal transduction and the development of new therapies for RAS driven tumors.

The LSP-based project coordinator and data scientist will have a PhD in biology, chemistry or a related discipline and experience with signal transduction or cancer biology. Excellent writing skills, the ability to work with others and good working knowledge of cell biology and cellular biochemistry is necessary.  Knowledge of computer programming is a plus but is not required.  The candidate will work as part of an interdisciplinary team of computational and experimental scientists and will learn about contemporary approaches to computer-aided analysis of biochemical mechanism. The candidate will also attend national and international conferences, serve as the public face of REM to NCI investigators, interact frequently with scientists in industry and contribute to papers.

Following an initial evaluation period the successful candidate will be appointed as a research associate for two years, with the possibility of renewal. It is not anticipated that the position will involve any experimental work, but this is not excluded for a candidate with the right qualifications. Interested individuals should send a CV, one-page sample of original writing and three letters of evaluation to lucy_dilworth@hms.harvard.edu at the LSP.


The Dean's Postdoctoral Fellowship
Co-Sponsored by: The Office for Diversity Inclusion and Community Partnership and The Office for Postdoctoral Fellows

As part of an effort to promote a diversity of backgrounds, perspectives, and experiences among its faculty and trainees, Harvard Medical School invites applications for the Dean’s Postdoctoral Fellowship.

The Office for Diversity Inclusion and Community Partnership in collaboration with The Office for Postdoctoral Fellows will award two-year postdoctoral fellowships per year to two promising researchers in the fields of basic or social sciences. The Dean’s Postdoctoral Fellowship at Harvard Medical School will prepare postdoctoral scientists, particularly scientists from minority and disadvantaged backgrounds, for cutting-edge research careers.  This fellowship will position the right candidate to make major contributions as scientific and societal leaders.

Fellows will benefit from a highly innovative and creative research environment that emphasizes scientific rigor, collaboration, and the pursuit of excellence in science.

For more info or to apply: http://www.hms.harvard.edu/dcp/deanspdfellowship/index.html

 

DEPARTMENTAL LISTINGS

BIOLOGICAL CHEMISTRY AND MOLECULAR PHARMACOLOGY

Blacklow Laboratory at Harvard Medical School
The Blacklow Laboratory at Harvard Medical School (Department of Biological Chemistry and Molecular Pharmacology) has an opening for a Postdoctoral position. The laboratory currently investigates structure-function relationships in Notch signaling, its downstream targets, and its epigenetic regulators.

Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry, Structural Biology or a related field.

Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to jobs_blacklowlab@hms.harvard.edu.

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BIOMEDICAL INFORMATICS

Avillach Laboratory at Harvard Medical School

Research Fellow Position at the Department of Biomedical Informatics (posted 10/16/15)

Description: The Department of Biomedical Informatics (DBMI) at Harvard Medical School is looking for a Research Fellow to help us build cutting edge research platforms. We seek an individual to work on our multidisciplinary team of data scientists, medical doctors, and developers. Our team studies large and disparate datasets from the domains of biology, healthcare and social media. The goal of our efforts is to transform healthcare and research to usher in a new age of individualized data driven medicine.
The Research Fellow will be responsible for developing novel methodologies and applications to help visual causal relationships in bioinformatics data sets. The diversity of subject matter will require a creative mind and a candidate capable of deploying imaginative strategies and who is dedicated to solving complex and challenging problems within an interdisciplinary environment.
Specific responsibilities for this position include:
• Work to understand data about causal relationships in order to develop visualizations.
• Create prototypes for visualizations and work with software professionals to integrate the work into an existing platform.
• Perform novel research on bioinformatics data sets and publish any findings.

For details and additional information: http://avillach-lab.hms.harvard.edu

 

Gehlenborg Laboratory at Harvard Medical School

Multiple postdoctoral fellowships are available immediately in the Gehlenborg Lab in the Department of Biomedical Informatics at Harvard Medical School. (posted 10/21/15)

Description:
The goal of the lab is to improve human health by developing computational techniques and interfaces that enable biomedical and clinical investigators to efficiently interact with biomedical data. We design, implement and evaluate methods and tools that leverage the knowledge and cognitive skills of investigators in order to enable the interpretation of massive heterogeneous data sets that integrate genomic and clinical data. Please see http://gehlenborglab.org for additional information about our work.

Possible research projects include development of data visualization, analysis, and management tools to study genomic structural variants, dynamics of the 3D genome, and cancer subtypes in patient cohorts. Further projects involve the design and implementation of visual exploration tools for biomedical data repositories and tools for viewing and interacting with provenance graphs. All of the projects are highly interdisciplinary and are being conducted in close cooperation with computational or experimental domain experts providing an excellent opportunity for collaborative research.

Our lab in the Department of Biomedical Informatics is part of a vibrant community of scientists, physicians, and engineers whose goal is to advance the boundaries of knowledge. The Department has recently been formed at Harvard Medical School to lead development of computational and informatics techniques to address pertinent challenges in modern biological sciences and medicine. The Department’s faculty conduct research at the intersection of biomedicine and information sciences, including bioinformatics, functional genomics, translational medicine, and clinical knowledge management. Based on the Harvard Medical School Longwood Campus, it provides a rich scientific environment, with many seminar series and invited speakers of the highest caliber.

For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/gehlenborg-lab

 

Kharchenko Laboratory at Harvard Medical School

A laboratory at the newly-formed Department of Biomedical Informatics at the Harvard Medical School (HMS) is looking to recruit several postdoctoral fellows interested in pursuing one or more of the following topics in computational biology:
I. Single-Cell Genomics
II. Computational analysis of epigenetic mechanisms disrupted in cancer and other disease-disrupted tissues
III. Computational analysis of nucleosome organization
(posted on 2/4/16)

For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/kharchenko-lab

 

Park Laboratory at Harvard Medical School

Applications are invited from those with excellent computational genomics training to work in the laboratory of Prof. Peter Park at Harvard Medical School. The long-term goal of the laboratory is to contribute to our understanding of cancer genetics, neuroscience, and epigenetics through computational analysis of sequencing data. (posted 2/4/16)
(1) single nucleotide variant analysis
(2) copy number analysis
(3) structural variation analysis (rearrangements and transposable elements)
(4) 3D chromatin organization
(5) ChIP-seq analysis (50/50 split between methods development and collaborative work). 

For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/park-lab

 

Patel Laboratory at Harvard Medical School

The Patel Group in the Harvard Medical School Department of Biomedical Informatics (http://chiragjpgroup.org) is looking for a Post-Doctoral research fellow to run a collaborative study with Northeastern University’s Antimicrobial Discovery Center that will uncover the characteristics of Lyme disease around the US leveraging emerging large and high-dimensional clinical data streams. Candidates must have a PhD in computer science, mathematics, physics, biomedical informatics, bioinformatics, or a related quantitative field. Preferred qualifications for this position include experience designing large software applications and infrastructure to store, retrieve, and analyze large datasets. Industry experience with R, Python, SQL is required. Experience in hacking with cloud technologies is great. Email applications including curriculum vitae, summary statement of personal objectives, and the names and email addresses of 2-3 references to Chirag Patel (chirag_patel@hms.harvard.edu). Harvard Medical School is an Equal Opportunity/Affirmative Action Employer. Women and minorities are especially encouraged to apply. (posted 3/2/16)

 

Biomedical Data Scientist Postdoctoral Associate (posted 2/4/16)
Imagine a dynamic dataset that encompasses comprehensive information about a patient in the health care system: what diseases they have, their genomic sequence, their social media messages (e.g, tweets and likes), and where they live. How would you—a data hacker—store, retrieve, and analyze this information to drive biomedical discovery to find a new way of predicting disease or even a new therapy for a disease? Chirag Patel’s Group at the Department of Biomedical Informatics at Harvard Medical School is looking for a data engineer to build cutting-edge platforms and data infrastructure to enable large-scale data-driven research to address this question. We aim to integrate diverse data sources from geotemporal information (e.g., NOAA Weather Data, EPA AirData), individual genomic sequence, social media data, and health claims information to paint a comprehensive picture of individuals who are sick and healthy.

For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/patel-group

 

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CELL BIOLOGY

Yuan Laboratory at Harvard Medical School
The Yuan laboratory at Harvard Medical School (Department of Cell Biology) has an immediate opening for a postdoctoral scientist. Our laboratory investigates the molecular mechanisms of cell death, including necroptosis and apoptosis, and their relevance for human diseases. This position is for a highly motivated individual with considerable experience in cell biology or related field. Experience in animal models of human diseases is desirable but not required.

Applicants should possess a Ph.D. and/or M.D. degree in molecular biology, cell biology, biochemistry, or neurobiology and a strong publication record. Interested individuals should send a curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to junying_yuan@hms.harvard.edu.

For additional information please visit our webpage: https://yuan.med.harvard.edu/


Liao Laboratory at Harvard Medical School

The Liao laboratory at Harvard Medical School (Department of Cell Biology) has an opening for a postdoctoral scientist. Our laboratory uses high-resolution single-particle electron cryo-microscopy (cryo-EM) to study the structure and function of membrane proteins. We seek a highly motivated individual with considerable experience in membrane protein biochemistry and is interested in learning cryo-EM techniques. Experience in X-ray crystallography is desirable but not required.

Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry, Structural Biology or a related field. Interested individuals should send a curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to maofu_liao@hms.harvard.edu.

For additional information please visit our webpage: http://liao.hms.harvard.edu/

 

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CENTER FOR BIOETHICS

- No listings at this time -

 

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GENETICS

Yanker Laboratory at Harvard Medical School
Positions available to study gene regulation, epigenetics and the molecular biology of aging and neurodegenerative diseases.  Projects focus on iPS cells, C. elegans, animal models and the biology of genes involved in aging and Alzheimer's disease. For reference see: Nature 507:448, 2014, J. Cell Biol. 203:457, 2013, Mol. Cell 40:333, 2010, Nature 464:529, 2010, Nature 429:883, 2004. Experience in molecular biology is required.

Send CV, a brief description of research experience and names of 3 references to: Dr. Bruce Yankner by email to aharwick@genetics.med.harvard.edu


Sinclair Laboratory at Harvard Medical School

Post-doctoral Scientist - position available immediately (10.14.15)
We are seeking a talented, highly motivated individual to join the laboratory headed by Professor David Sinclair in the Genetics Department at Harvard Medical School, Boston. The Sinclair lab is known for their work on genes and small molecules that delay aging with a focus on Sirtuins and small molecule activators such as resveratrol. The laboratory has a record of innovation with over 30 patents and numerous start-up companies. In 2014, Dr. Sinclair was on the TIME100 list of the “most influential people in the world.”
The individual will design and conduct laboratory research under the direction of the lab head to identify natural and synthetic small molecules to delay and reverse aging, with a focus on skin aging. The individual will present regular updates to academic and industry collaborators as well as prepare and publish research reports. Candidate may occasionally be required to travel within the U.S. and overseas.
The ideal candidate will have a record of scientific rigor, creativity, and ability to work in teams, with a strong publication record in peer-reviewed scientific journals. Candidate should have a strong background in enzymology, biochemistry, and molecular biology, and be familiar with microbial genetics and mammalian cell culture. Excellent oral and written communication skills are required. The individual will be required to work efficiently as part of an international team with performance measures and time constraints. Proficiency in French is desirable but not essential.
Harvard Medical School Harvard Medical School - Genetics Dept. - salary commensurate with experience
To apply: http://jobs.sciencecareers.org/job/382649/post-doctoral-scientist/#apply-form

The Sinclair laboratory at Harvard Medical School (Departments of Pathology and Genetics) has immediate openings for Postdoctoral Scientists. The laboratory studies genes and small molecules that can slow the pace of aging and age-related diseases. Various projects are available, including studies of neurological diseases, cancer, type I and type II diabetes, muscle metabolism and mitochondria, inflammation, and fertility. Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry or a related field. Training in mammalian cell biology and/or physiology is highly desirable though not essential.

Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to david_sinclair@hms.harvard.edu.


Seidman Laboratory at Harvard Medical School
The Seidman lab in the HMS Department of Genetics has a joint postdoctoral position available in the area of human genetics and computational genomics. Our lab uses high throughput DNA sequence analysis to identify genetic variants that are responsible cardiac disease. We are currently integrating results from genome-wide association studies, RNA expression analyses and DNA sequence analyses to identify gene variants responsible for cardiac phenotypes. We seek a highly motivated individual with considerable computational experience as well as molecular biology experience that is interested in integrating diverse data sources to gain mechanistic insights into atrial fibrillation. The ideal applicant will have experience with computational genomics, databases, and statistical inference, as well as molecular biological techniques.

In addition a strong publication record and an ability to work in team settings is essential. Please submit a cover letter detailing your research motivations and a CV with three references to Susanne Bartlett (bartlett@genetics.med.harvard.edu)

 

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GLOBAL HEALTH AND SOCIAL MEDICINE

Research Fellowship

The Department of Global Health and Social Medicine seeks a postdoctoral fellow to support the design and evaluation of large-scale intervention programs forming part of the core research and teaching activities of the Harvard Medical School Center for Global Health Delivery-Dubai. The Center has three concurrent missions: (1) to conduct and publish cutting edge health delivery research on innovative approaches to addressing health problems of critical importance to the region and world; (2) to train the next generation of scholars and practitioners from Dubai and the region in global health delivery; and (3) to enable Dubai to serve as an important regional hub for discussions and policy formulation on health problems of critical importance to Dubai, the United Arab Emirates, the region, and the world. This position is employed by a Dubai-based affiliate of Harvard Global Research and Support Services Inc. (Harvard Global). Harvard Global is itself a wholly controlled affiliate of Harvard University.

The successful candidate would have epidemiological and biostatistical background, and experience in designing studies and analytic plans, data analysis and interpretation, report and manuscript writing.  The fellowship is funded by the Center to train postdoctoral candidates for a successful research career as an epidemiologist/biostatistician focused on global health delivery. The minimal required qualification is a doctoral degree (PhD, DRPH, ScD or equivalent) in epidemiology, biostatistics, public health or related discipline. The position will be based in Dubai and will be offered for one year (renewable for one additional year based on performance).  The ideal candidate will have finished their doctoral studies within five years of the date of application.  Knowledge of Arabic is an asset but not required.

Applicants must send a cover letter stating their long-term career aims and suitability for the position, curriculum vitae, statement of teaching interests, statement of research plans, and names and contact information for at least three potential references. Email applications to rgrow@hms.harvard.edu by July 7, 2016. The position is scheduled to start on September 1. Applications will be accepted until the position is filled.

Candidates should be eligible for employment sponsorship in Dubai, United Arab Emirates. Offers are conditional on proper work authorization. A signed employment agreement will be issued by Harvard Global’s affiliate and may include a pre-employment background and reference checks. Harvard Global and its affiliates are equal opportunity employers and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

Start date:  September 1, 2016
Location: Dubai, United Arab Emirates

For additional information, see:  HMS Center for Global Health Delivery—Dubai


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HARVARD CATALYST

Post-doctoral Research Fellow – The Football Players Health Study

The Football Players Health Study at Harvard University aims to evaluate and improve the health and wellbeing of former professional football players. The Study is funded by the NFL Players Association (NFLPA) and is one of the largest sports research projects ever undertaken.  The Study is researching the prevalence and severity of medical conditions that affect the quality and longevity of life of football players and working to identify and prioritize promising new approaches to prevent, diagnose and treat those conditions that afflict them. The Study strives to meet its aims by collecting data directly from players, by supporting innovative research through pilot awards, and by investigating ethical considerations of players’ conditions. The research program sits within Harvard Catalyst | The Harvard Clinical and Translational Science Center. Harvard Catalyst facilitates clinical and translational research throughout the 27 Harvard schools and Academic Healthcare Centers (Massachusetts General Hospital, Boston Children's Hospital, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and others) by educating and training investigators, providing tools and technologies that enable their research, and bringing diverse communities together to accelerate the pace of investigation.

The Football Players Health Study at Harvard University is seeking a highly motivated post-doctoral research fellow (PhD, MD or MD/PhD) who will help to further study design, write IRB protocols, and conduct data analysis under the guidance and direction of our lead investigators.  Additional responsibilities include coordinating with the IRB, presenting work at local and national meetings, and writing scientific manuscripts.  The position will be co-mentored by Drs. Alvaro Pascual-Leone and William Meehan.  This is a one- year position with the option to renew annually.

Requirements:
Applicants must have a doctoral degree (PhD, MD or MD/PhD) in a relevant area; including any medical specialty or scientific field with a dedicated interest in the care of athletes.  Ability to handle confidential and sensitive information discreetly is required.

Other preferred requirements include:
-- Ability to design and conduct data analysis for cross-sectional and longitudinal studies.
-- Proven ability and experience in a subset of SAS, SPSS or related statistical packages.
-- Excellent oral and written skills.
-- Speak fluently in English.

Please submit letter of interest, CV, one copy of any relevant publication, and names/addresses of three references to Dr. Supriya Krishnan (Supriya_krishnan@hms.harvard.edu)

 

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HEALTH CARE POLICY
No positions currently listed.

 

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MICROBIOLOGY AND IMMUNOBIOLOGY

Gack Laboratory at Harvard Medical School
Two postdoctoral positions are available immediately in the laboratory of Dr. Michaela Gack at the Department of Microbiology and Immunobiology of Harvard Medical School to conduct cutting-edge research at the interface of immunology and virology. Specifically, the project will investigate the molecular mechanisms of how the innate immune system restricts the replication of polyomaviruses and other viral pathogens in various cell culture assays and mouse models.

Candidates should be accomplished in virology, molecular biology, biochemistry and/or immunology. Experience with DNA viruses, in particular polyomaviruses, and mouse infection studies would be especially desirable.

Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Michaela Gack, Ph.D.
Department of Microbiology and Immunobiology
Harvard Medical School
Email: michaela_gack@hms.harvard.edu


Yang Laboratory at Harvard Medical School

The Yang Lab has two immediate openings for postdoctoral fellows to play a vital role in the discovery and optimization of small molecule antivirals. Must have established expertise in protein expression (microbial, insect, and mammalian cells) and purification as well as with a variety of biophysical and biochemical methods for characterizing protein-small molecule interactions. Experience with high-throughput screening and/or molecular virology techniques is desired but may be substituted with a willingness and aptitude to learn. Must be willing to work with viral pathogens in a BSL2+ lab.

You will be working within a multidisciplinary group of structural biologists, medicinal chemists, biochemists, and virologists. This position requires excellent communication and organizational skills, and a willingness to help train and mentor more junior members on the research team. This is an excellent opportunity for a post-doctoral fellow to acquire experience relevant to future employment in industry while still operating within an academic environment. This position is funded by an NIH grant through 2018. Applicants are expected to make a 3 year commitment.

Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Priscilla L. Yang., Ph.D.
Department of Microbiology and Immunobiology
Harvard Medical School
Email: Priscilla_yang@hms.harvard.edu

 

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NEUROBIOLOGY

Gu Laboratory at Harvard Medical School
A postdoctoral position is available to study the coordinate development of nervous and vascular systems using mouse genetics, biochemistry, imaging, and in vitro assays. Applicants should be accomplished in biochemistry, molecular biology, cell biology. Experience in the biochemical and functional characterization of proteins in the signaling pathways would be especially desirable.

Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:

Chenghua Gu, D.V.M., & Ph.D
Department of Neurobiology
Harvard Medical School
Email: chenghua_gu@hms.harvard.edu
HMS Dept. of Neurobiology Website: http://neuro.med.harvard.edu/


Weitz Laboratory at Harvard Medical School
A postdoctoral position is available to study protein complexes comprising the core of the mammalian circadian clock, a molecular oscillator present in multiple tissues that regulates physiology, metabolism, and behavior.  Applicants should be accomplished in biochemistry, molecular biology, and/or cell biology.  Experience in the biochemical and functional characterization of protein complexes would be especially desirable.

Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Charles J. Weitz, M.D., Ph.D.
Department of Neurobiology
Harvard Medical School
Email:  cweitz@hms.harvard.edu
HMS Dept. of Neurobiology Website:  http://neuro.med.harvard.edu/

Some recent papers:
Duong HA, Robles MS, Knutti K, Weitz CJ.  A molecular mechanism for circadian clock negative feedback. Science  2011; 332: 1436-9.

Padmanabhan K, Robles MS, Westerling T, Weitz CJ.  Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science  2012; 337:  599-602. 

Kim JY, Kwak PB, Weitz CJ.  Specificity in circadian clock feedback from targeted reconstitution of the NuRD co-repressor.  Molecular Cell  2014; 56: 738-748.

Tamayo AG, Duong HA, Robles MS, Mann M, Weitz CJ.  Histone mono-ubiquitination by Clock–Bmal1 complex marks Per1 and Per2 genes for circadian feedback. Nature Structural & Molecular Biology 2015; 22: 759-766.  


Goodrich Laboratory at Harvard Medical School

The Goodrich lab is seeking a postdoctoral fellow to study the development of neural circuits in the auditory system. We use mouse genetics to understand how changes in the circuits of the inner ear affect an animalís ability to detect and perceive sound. Projects employ a variety of techniques, including biochemical analysis of novel proteins, in vitro culturing of inner ear neurons, imaging of single cells during auditory circuit assembly, and gene expression profiling of wild-type and mutant cells. No experience with the auditory system is required, but a familiarity with neuroscience or mouse genetics is a plus. Individuals with expertise in cell biology, imaging, microarrays, or signal transduction are particularly encouraged to apply.

Please send a cover letter, CV, and three references to:

Dr. Lisa Goodrich
Dept of Neurobiology, Harvard Medical School
220 Longwood Avenue
Goldenson 442
Boston, MA 02115
Email: Lisa_Goodrich@hms.harvard.edu

 

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SYSTEMS BIOLOGY


Mootha Laboratory at Harvard Medical School
The Mootha laboratory (Department of Systems Biology) has a funded opportunity for a postdoctoral scientist in computational genetics.

The laboratory focuses on mitochondrial biology and disease and consists of a lively group of computational biologists, experimental biochemists, and physician-scientists. We are currently seeking a postdoctoral scientist to work at the interface of human genetics and systems biology, with the goal of analyzing very large scale human genome sequence datasets using network models of mitochondria derived from cellular and biochemical studies, to address questions spanning disease, epistasis, and evolution.

Applicants should possess a Ph.D. and/or M.D. degree in computational biology, preferably with a proven track record in computational genetics and analysis of next-generation sequencing data. Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to vamsi@hms.harvard.edu.

For additional information please visit our webpage: http://mootha.hms.harvard.edu/


Fontana Laboratory at Harvard Medical School
The Fontana Laboratory is seeking two outstanding post-docs to accomplish in collaboration with other groups a prototype end-to-end pipeline that extracts detailed mechanistic information about protein-protein interactions from databases and text, assembles such information into executable reference models for the purpose of understanding their dynamical behavior and assessing the current knowledge base in specific cell signaling systems. A can-do attitude, hacker soul, originality coupled to team spirit, fearlessness, and dedicated work ethic are necessary characteristics. Pay is commensurate to experience.

Position 1: Computer science / AI / bioinformatics / databases
The ideal candidate combines an interest, and possibly expertise, in Artificial Intelligence (text extraction, natural language processing, reasoning) with bioinformatic skills. The individual will collaborate with other groups in excavating information about molecular interactions from extant databases and text; organizing such information for translation into a formal and executable format from which models of cellular signaling are constructed. The candidate should be capable of scripting in Python or Perl, be familiar with procedural and functional programming paradigms (e.g. Java or similar and OCaml or similar) and have database experience.

Position 2: Modeler / cellular signaling / cancer pathways
The ideal candidate is a computational biologist with experience in modeling dynamical systems. The individual is a skilled programmer (C, C++ or similar, experience with OCaml a plus) who will work with Kappa, a formal agent-based modeling language (https://github.com/jkrivine/KaSim) and associated tools. Ease with formal / mathematical thinking is required. A sound instinct for molecular biology coupled to a physics mindset is highly desirable. The position functions as a modeling keystone within an ambitious project seeking to build large dynamic “reference models" of cell signaling networks involved in RAS-related cancers. Models of such networks are assembled using mechanistic knowledge extracted from databases and texts in collaboration with outside groups providing pertinent expertise.

To apply, send CV and a covering letter to Walter Fontana: walter@hms.harvard.edu.


Megason Laboratory at Harvard Medical School
A postdoctoral research fellow position is available in the Megason lab in the Department of Systems Biology at Harvard Medical School in the areas of embryology, genetics, imaging, and systems biology. The Megason Lab has initiated a project to generate a Digital Fish which is a computer recreation of how the genome is executed to turn an egg into an embryo. We combine novel imaging technologies called in toto imaging to extract quantitative molecular and cellular data from living, developing zebrafish embryos for use in modeling. In toto imaging uses confocal and 2-photon microscopy to image and track every cell in developmental processes to reconstruct complete digital cell lineages. We also are developing a novel genetic approach called FlipTraps which generate endogenously expressed fluorescent fusion proteins and Cre condtional alleles. We combine these approaches to generate quantitative models of how systems of molecules program cells and systems of cells program tissues. Additionally, we are particularly interested in applicants with experience, expertise, and interest in home built 2-photon microscopy systems. For more information please contact Sean Megason (megason@hms.harvard.edu) or visit our website www.digitalfish.org.

A cover letter detailing your research motivations and a curriculum vitae should be sent by email to the above address together with the names of three referees with contact information.

Sean Megason, PhD
Department of Systems Biology
Harvard Medical School
200 Longwood Avenue, WAB 536
Boston, MA 02115

 

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HARVARD SCHOOL OF DENTAL MEDICINE

 

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WYSS INSTITUTE


Postdoctoral Fellows Positions at the Wyss Institute for Biologically Inspired Engineering

The Wyss (pronounced "Veese") Institute for Biologically Inspired Engineering uses Nature's design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world.

Working as an alliance among Harvard's Schools of Medicine, Engineering, and Arts & Sciences, and in partnership with Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Dana Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Tufts University, and Boston University, the Institute crosses disciplinary and institutional barriers to engage in high-risk research that leads to transformative technological breakthroughs.


Visit the Wyss Institute's website to find out positions available: http://wyss.harvard.edu/viewpage/191/postdoctoral-positions



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