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~FEATURED FELLOWSHIP OPPORTUNITY~

The Dean's Postdoctoral Fellowship
Co-Sponsored by: The Office for Diversity Inclusion and Community Partnership and The Office for Postdoctoral Fellows

As part of an effort to promote a diversity of backgrounds, perspectives, and experiences among its faculty and trainees, Harvard Medical School invites applications for the Dean’s Postdoctoral Fellowship.

The Office for Diversity Inclusion and Community Partnership in collaboration with The Office for Postdoctoral Fellows will award two-year postdoctoral fellowships per year to two promising researchers in the fields of basic or social sciences. The Dean’s Postdoctoral Fellowship at Harvard Medical School will prepare postdoctoral scientists, particularly scientists from minority and disadvantaged backgrounds, for cutting-edge research careers.  This fellowship will position the right candidate to make major contributions as scientific and societal leaders.

Fellows will benefit from a highly innovative and creative research environment that emphasizes scientific rigor, collaboration, and the pursuit of excellence in science.

For more info or to apply: http://www.hms.harvard.edu/dcp/deanspdfellowship/index.html

 

Nancy Lurie Marks Postdoctoral Fellowship
Co-Sponsored by: The Nancy Lurie Marks Family Foundation and Harvard Medical School

This fellowship is intended to provide salary support to the postdoctoral fellow and limited funds for research supplies.

Eligibility:
•  Must hold an MD and/or PhD
•  Must be affiliated with Harvard Medical School or a Harvard-affiliated hospital
•  Must have at least 2 years prior postdoctoral research experience
•  Must be actively engaged in research related to autism

To apply please submit in a single PDF to the email address below:
            •  A cover letter with your contact information
            •  Your CV
            •  A five-page proposal including one page of specific aims, one page of background and significance, and three pages describing the research plan and experimental approach (references can be on a separate page)

Applicants should also arrange to have three letters of recommendation
from individuals familiar with your research and your future potential as an investigator, including a letter of support from your postdoctoral advisor for the proposed project, sent directly to the email address below.

Applications are due Friday, March 22, 2013
Please email all materials and questions to NLM_fellowship@hms.harvard.edu

 

 

DEPARTMENTAL LISTINGS

BIOLOGICAL CHEMISTRY AND MOLECULAR PHARMACOLOGY

Blacklow Laboratory at Harvard Medical School
The Blacklow Laboratory at Harvard Medical School (Department of Biological Chemistry and Molecular Pharmacology) has an opening for a Postdoctoral position. The laboratory currently investigates structure-function relationships in Notch signaling, its downstream targets, and its epigenetic regulators.

Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry, Structural Biology or a related field.

Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to jobs_blacklowlab@hms.harvard.edu.

 

CELL BIOLOGY
No positions currently listed.

 

 

GENETICS

Sinclair Laboratory at Harvard Medical School
The Sinclair laboratory at Harvard Medical School (Departments of Pathology and Genetics) has immediate openings for Postdoctoral Scientists. The laboratory studies genes and small molecules that can slow the pace of aging and age-related diseases. Various projects are available, including studies of neurological diseases, cancer, type I and type II diabetes, muscle metabolism and mitochondria, inflammation, and fertility. Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry or a related field. Training in mammalian cell biology and/or physiology is highly desirable though not essential.

Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to david_sinclair@hms.harvard.edu.

Seidman Laboratory at Harvard Medical School
The Seidman lab in the HMS Department of Genetics has a joint postdoctoral position available in the area of human genetics and computational genomics. Our lab uses high throughput DNA sequence analysis to identify genetic variants that are responsible cardiac disease. We are currently integrating results from genome-wide association studies, RNA expression analyses and DNA sequence analyses to identify gene variants responsible for cardiac phenotypes. We seek a highly motivated individual with considerable computational experience as well as molecular biology experience that is interested in integrating diverse data sources to gain mechanistic insights into atrial fibrillation. The ideal applicant will have experience with computational genomics, databases, and statistical inference, as well as molecular biological techniques.

In addition a strong publication record and an ability to work in team settings is essential. Please submit a cover letter detailing your research motivations and a CV with three references to Susanne Bartlett (bartlett@genetics.med.harvard.edu)

 

 

MICROBIOLOGY AND IMMUNOBIOLOGY

Yang Laboratory at Harvard Medical School
The Yang laboratory at Harvard Medical School (Department of Microbiology and Immunobiology) has an immediate opening for a Postdoctoral Scientist. The laboratory studies cellular and biochemical mechanisms of viral replication using a combination of chemical biology, cell biology, biochemistry, and molecular biology. Various projects are available, including studies of dengue virus, hepatitis C virus, and hepatitis B virus. Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry or a related field. Training in molecular virology is highly desirable.

Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to Priscilla_yang@hms.harvard.edu.

 

 

NEW ENGLAND PRIMATE RESEARCH CENTER
No positions currently listed.

 

 

NEUROBIOLOGY

Anderson Lab at Harvard Medical School
Postdoctoral fellowship position available for individuals with expertise in bacterial artificial chromosome (BAC) recombineering. Join in our effort to uncover the molecular and cellular basis of neuronal circuit defects underlying novel genetic mouse models of human autism and epilepsy generated in our lab. Other investigators in the laboratory utilize transcript profiling, proteomics, brain slice patch clamp electrophysiology, optogenetics, mouse behavioral analysis, and in vivo unit recordings. Develop novel transgenic mouse tools to reconstitute newly discovered diseases and to facilitate molecular and functional analysis of neuronal circuit. Recent studies investigate the functions of a human-specific long non-coding RNA duplicated in autism and critical to human brain evolution.

Zhou Y-D, Lee S, Jin Z, Wright M, Smith SEP, Anderson MP. Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Nature Medicine. 2009;15:1208. (editorial, Epilepsy: synapses stuck in childhood. Caleo M. Nat Med. 2009; 15:1126-7)

Czupryn A, Zhou YD, Chen X, McNay D, Anderson MP*, Flier JS*, Macklis JD*.
Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science. 2011;334:1133-7.
* equal contribution

Smith SE, Zhou YD, Zhang G, Jin Z, Stoppel DC, Anderson MP. Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice. Science Transl Med. 2011;3:103ra97. (www.aaas.org/news/releases/2011/1005sp_mouse_autism.shtml)

Contact: Matthew P. Anderson, M.D., Ph.D.
Principle Investigator, Program in Neuroscience, Harvard Medical School
Associate Professor, Harvard Medical School
Director of Neuropathology, Beth Israel Deaconess Medical Center
Email: mpanders@bidmc.harvard.edu
Tel: (617) 735-3202
www.hms.harvard.edu/dms/neuroscience/fac/Anderson.html

 

Gu Laboratory at Harvard Medical School
A postdoctoral position is available to study the coordinate development of nervous and vascular systems using mouse genetics, biochemistry, imaging, and in vitro assays. Applicants should be accomplished in biochemistry, molecular biology, cell biology. Experience in the biochemical and functional characterization of proteins in the signaling pathways would be especially desirable.

Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:

Chenghua Gu, D.V.M., & Ph.D
Department of Neurobiology
Harvard Medical School
Email: chenghua_gu@hms.harvard.edu
HMS Dept. of Neurobiology Website: http://neuro.med.harvard.edu/

Anderson Lab at Harvard Medical School
A postdoctoral position is available to study our newly generated genetic mouse models of human autism and epilepsy disorders (Glessner et al. Nature 2009; Zhou et al. Nature Medicine 2009). We are multiple fully funded positions for PhDs with expertise in the following disciplines:

1. Slice patch-clamp electrophysiology with concurrent confocal (or multi-photon) microscopy.
2. In vivo multi-unit recording of neuronal activity in awake behaving mice (e.g., place cells, head-direction cells).
3. Large intergenic non-coding RNA studies.
4. Protein complex isolation with mass spectrometry.

Please send cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Matthew P. Anderson, M.D., Ph.D.
Departments of Neurology and Pathology, Harvard Medical School
Program in Neuroscience, Harvard Medical School
Director of Neuropathology, Beth Israel Deaconess Medical Center
Email: Matthew_Anderson@bidmc.harvard.edu
Web Site: http://www.hms.harvard.edu/dms/neuroscience/Faculty.html

Recent publication:
Zhou Y-D, Lee S, Jin Z, Wright M, Smith SEP, Anderson MP. Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Nature Medicine. 2009;15(10):1208-14.
Smith SEP, Jin Z, Zhang G, Zhou Y-D, Wang X, Anderson MP. Molecular and cellular basis of 15q11-13 autism. Nature (submitted)

Weitz Laboratory at Harvard Medical School
A postdoctoral position is available to study protein complexes comprising the core of the mammalian circadian clock, a molecular oscillator present in multiple tissues that regulates physiology, metabolism, and behavior.  Applicants should be accomplished in biochemistry, molecular biology, and/or cell biology.  Experience in the biochemical and functional characterization of protein complexes would be especially desirable.

Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Charles J. Weitz, M.D., Ph.D.
Department of Neurobiology
Harvard Medical School
Email:  cweitz@hms.harvard.edu
HMS Dept. of Neurobiology Website:  http://neuro.med.harvard.edu/

Some recent papers:
Robles MS, Boyault C, Knutti D, Padmanabhan K, Weitz CJ.  Identification of RACK1 and Protein Kinase Ca as integral components of the mammalian circadian clock.  Science  2010; 327: 463-466.
Storch K-F, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T, Weitz CJ.   Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information.  Cell  2007; 130: 730-741.

Goodrich Laboratory at Harvard Medical School
The Goodrich lab is seeking a postdoctoral fellow to study the development of neural circuits in the auditory system. We use mouse genetics to understand how changes in the circuits of the inner ear affect an animal’s ability to detect and perceive sound. Projects employ a variety of techniques, including biochemical analysis of novel proteins, in vitro culturing of inner ear neurons, imaging of single cells during auditory circuit assembly, and gene expression profiling of wild-type and mutant cells. No experience with the auditory system is required, but a familiarity with neuroscience or mouse genetics is a plus. Individuals with expertise in cell biology, imaging, microarrays, or signal transduction are particularly encouraged to apply.

Please send a cover letter, CV, and three references to:

Dr. Lisa Goodrich
Dept of Neurobiology, Harvard Medical School
220 Longwood Avenue
Goldenson 442
Boston, MA 02115
Email: Lisa_Goodrich@hms.harvard.edu

 

 

SYSTEMS BIOLOGY

Megason Laboratory at Harvard Medical School
A postdoctoral research fellow position is available in the Megason lab in the Department of Systems Biology at Harvard Medical School in the areas of embryology, genetics, imaging, and systems biology. The Megason Lab has initiated a project to generate a Digital Fish which is a computer recreation of how the genome is executed to turn an egg into an embryo. We combine novel imaging technologies called in toto imaging to extract quantitative molecular and cellular data from living, developing zebrafish embryos for use in modeling. In toto imaging uses confocal and 2-photon microscopy to image and track every cell in developmental processes to reconstruct complete digital cell lineages. We also are developing a novel genetic approach called FlipTraps which generate endogenously expressed fluorescent fusion proteins and Cre condtional alleles. We combine these approaches to generate quantitative models of how systems of molecules program cells and systems of cells program tissues. Additionally, we are particularly interested in applicants with experience, expertise, and interest in home built 2-photon microscopy systems. For more information please contact Sean Megason (megason@hms.harvard.edu) or visit our website www.digitalfish.org.

A cover letter detailing your research motivations and a curriculum vitae should be sent by email to the above address together with the names of three referees with contact information.

Sean Megason, PhD
Department of Systems Biology
Harvard Medical School
200 Longwood Avenue, WAB 536
Boston, MA 02115

 

 

HEALTH CARE POLICY
No positions currently listed.

 

 

NEW ENGLAND PRIMATE RESEARCH CENTER (NEPRC)
No positions currently listed.

 

 

HARVARD SCHOOL OF DENTAL MEDICINE

Wang Laboratory at Harvard School of Dental Medicine
The Harvard School of Dental Medicine is internationally acclaimed for excellence in clinical care, education, and scientific research.  We are seeking a motivated and enthusiastic Postdoctoral Research Fellow to study the molecular genetics of craniofacial and tooth development.  Our current emphasis is on the understanding of the role of Wnt and Hippo signaling in tooth development and tooth regeneration.  In addition, we also use the continuously growing mouse incisor as a model to study adult stem cells and stem cell regulations.

Candidates should hold a Ph.D., M.D., or D.D.S. degree, have peer reviewed publications and a thorough background in molecular biology, developmental biology, cell biology, and biochemistry with experience in using cell culture, fluorescence microscopy and animal experimental approaches.  Must be proficient (oral and written) in English.  Please send a cover letter, CV, and the names and email addresses of three references via email to: Dr. Xiu-Ping Wang (xiuping_wang@hsdm.harvard.edu) at the Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115.

 

 

WYSS INSTITUTE

Chaikof Laboratory at Harvard Medical School and the Wyss Institute of Biologically Inspired Engineering
NIH funded postdoctoral position available in the laboratory of Dr. Elliot Chaikof at Harvard Medical School and the Wyss Institute of Biologically Inspired Engineering at Harvard University (wyss.harvard.edu/viewpage/224). The project is directed at harnessing biologically inspired designs to limit blood clotting on artificial surfaces. The successful candidate will interact within an interdisciplinary group of scientists and engineers involved in physiochemical, biological, and in vivo investigations of genetically engineered enzymes and molecularly engineered surfaces. Experience in recombinant gene technology, bio-orthogonal chemistry, thin films, and/or surface chemistry desirable. Ph.D. is required.

Submit CV and three references to challer@bidmc.harvard.edu.


Chaikof Laboratory at Harvard Medical School and the Wyss Institute of Biologically Inspired Engineering
NIH funded postdoctoral position available in the laboratory of Dr. Elliot Chaikof at Harvard Medical School and the Wyss Institute of Biologically Inspired Engineering at Harvard University (wyss.harvard.edu/viewpage/224) to focus on strategies to improve islet transplantation for the treatment of diabetes. Investigations will seek to develop new strategies to limit thrombotic and innate immune responses at the time of transplantation to improve early and late outcomes. Experience in recombinant gene technology, bio-orthogonal chemistry, local drug delivery, and/or innate and adaptive immunity is desirable. Ph.D. is required.

Submit CV and three references to challer@bidmc.harvard.edu.

Postdoctoral Position in Respiratory Cell Biology and Physiology
The Wyss Institute for Biologically Inspired Engineering at Harvard University invites applications for a postdoctoral fellow position in the Biomimetic Microsystems platform. The mission of the Wyss Institute is to discover the engineering principles that Nature uses to build living things; to pursue the high-risk research that is fundamental to advance this effort; and to harness these insights to create biologically-inspired materials and devices to advance human health and improve the environment – thereby revolutionizing clinical medicine and creating a more sustainable world.

We seek outstanding postdoctoral applicants with expertise in respiratory cell biology and physiology and/or surface barrier (mucosal) inflammation to join an interdisciplinary team of biologists and engineers for the development of novel in vitro “organ-on-chip” microsystems technologies to study and model pulmonary disorders (Huh D et al. Science 2010). Applicants are expected to hold a PhD or MD and have a proven record of high quality publications in respiratory biology and/or surface barrier inflammation. Strong interest in contributing to multidisciplinary teams (engineers, biologists/physiologists, clinicians) is critical for this position. Expertise in in-vitro culture of respiratory cell lines and primary human cells, as well as knowledge of basic molecular biology concepts and techniques is a must. The ideal candidate would bring expertise in respiratory cell biology, physiology, and pathophysiology, with an interest in applying this expertise in combination with modern bioengineering methods such as microfabrication and microfluidics. This postdoctoral fellow is expected to develop and lead an interdisciplinary research project aimed at creating microengineered human “organ-on-chip” models and exploring their use for drug discovery applications.

Applications, assembled as single PDF files, should contain a complete resume, cover letter describing research interests and goals, full list of publications, copies of up to three relevant scientific papers, as well as the names and contact information of three references (expected to provide letters of recommendation).

Applications should be sent to faculty_postdocs@wyss.harvard.edu.

For additional information please visit our webpage: http://wyss.harvard.edu/

 

 

W. ROXBURY VA HOSPITAL
No positions currently listed.

POSTDOC OPPORTUNITIES @ HMS AFFILIATED INSTITUTIONS

Krichevsky Lab at The Center for Neurologic Diseases at BWH
A postdoctoral position is available to study functions of microRNAs and other non-coding RNAs in human CNS disorders such as brain tumors and neurodegeneration of aging. In addition to studying basic biology of disease-associated non-coding RNA, we also use various cell-based and animal models to develop RNA-based therapeutic and diagnostic tools.

Extensive experience in molecular and cell biology is required. Preference will be given to candidates with strong background in cancer biology, neurobiology and/or computational biology/bioinformatics. Experience with animal surgery is a plus. The candidate should possess effective oral and written communication skills, and an established publication record.

Highly motivated Ph.D. or M.D./Ph.D. applicants should send curriculum vitae, a cover letter detailing research interests, and complete contact information for three references to Dr. Anna Krichevsky at akrichevsky@rics.bwh.harvard.edu

 

Postdoctoral Fellowship Opportunities in Transfusion Biology and Cellular Therapies
Applications are now being accepted for Postdoctoral (M.D. or Ph.D.) Fellows who desire research careers in the expanding, multidisciplinary field transfusion medicine and cellular therapy. The program offers a stimulating environment with various basic science and applied research opportunities, and is supported by senior faculty in the Departments of Pediatrics, Pathology, Hematology/Oncology, Immunology and Genetics. Fellows will conduct independent research for two years under the direction of one mentor, with opportunities for collaborative and inter-laboratory projects. The principal research fields include stem cell biology including immune modulation, gene therapy, cancer immunology, platelet biology, and hematopoiesis. Publication in an international peer-reviewed journal is a prerequisite for acceptance into the program. As per NIH guidelines, candidates must be a citizen of the U.S. or hold permanent residency status in the U.S. to apply. Affirmative Action/Equal Opportunity Employer

Deadline for applications is Friday, June 14, 2013

Send curriculum vitae, statement of interest, and three reference letters (one of which should be from the lab where the research will be conducted) to:
Leslie E. Silberstein, M.D, Director, Joint Program in Transfusion Medicine
c/o Allison Swanson
Boston Children's Hospital
320 Longwood Avenue
Enders Research Building, 8th floor, Room 807
Boston, MA 02115

or via e-mail to allison.swanson@childrens.harvard.edu

For questions regarding this postdoctoral fellowship opportunity, please contact Allison Swanson at allison.swanson@childrens.harvard.edu

 

Rittling Laboratory at the Forsyth Institute
A postdoctoral research position in the Rittling laboratory at The Forsyth Institute is available to study the role of osteopontin and its associated integrin receptors in innate immunity. We are using mouse models of polymicrobial infection to analyze the cellular and molecular response to these infections, with the goal of maximizing the host response. The project will involve the analysis of the role of OPN and its integrin binding partners the alphav, beta3, beta5 and alpha9 integrins in myeloid cell migration, function, and signaling using knockout mouse models, blocking peptides and other strategies, including cellular and molecular biology techniques.

The Forsyth Institute, the world’s leading oral health research institute, is located in the Kendall Square area of Cambridge MA adjacent to downtown Boston and is a Harvard Affiliate. The position is NIH funded, requires 0-2 years of experience beyond the PhD; expertise in cell biology, mouse breeding and/or flow cytometry would be an advantage. US citizenship or green card status is preferred. A demonstrated record of publication and independent thinking required.

Please send a cover letter, CV, statement of research interests and goals, and the names of three references to Susan Rittling at srittling@forsyth.org.

 

Lahav Laboratory at Brigham and Women's Hospital
A postdoctoral position is currently available in the Lahav Lab for Neonatal Research at Brigham and Women’s Hospital and Harvard Medical School.
Our work is focused on studying the effects of the sensory environment in the neonatal intensive care unit on early brain maturation and long-term outcomes in extremely premature infants. The main research question we would like to answer is how different types of prenatal experience spill over and affect postnatal development. We develop clinical protocols and technological innovations with the goal of enriching the NICU environment with biological reproduction of the maternal womb-like experience. For further information, please see our website: http://lahav-lab.bwh.harvard.edu/

Candidates should have a PhD and/or MD with proven background in developmental psychology, child development, epidemiology, pediatrics, perinatal medicine, clinical trials, auditory neuroscience, brain imaging, audiology, biomedical engineering, or a related field. The ideal applicant will have extensive background in multivariate statistics and strong publication record.

To apply, send a cover letter, CV, and contact information for three references directly to Amir Lahav (amir@hms.harvard.edu)

 

Signoretti Laboratory at Brigham and Women's Hospital
NIH-funded post-doctoral position available to study mechanisms regulating prostate epithelium maintenance and regeneration. A clear understanding of the way prostate epithelial cells are renewed in vivo is critical for the identification of the cell of origin of prostate cancer and the clarification of the multi-step process that leads to neoplastic transformation. This project aims to the identification of prostate stem cells and the molecular mechanisms that regulate their functions. It involves working with mouse models and primary prostate cells in culture.

Requirements: US Citizen or permanent US Residency required. We are seeking a highly motivated applicant with M.D. or Ph.D. degree in biology/biochemistry/molecular biology and strong experience in molecular and cell biology. Previous experience working with mice is highly preferred. Good written and oral communication skills, and good publication record are highly desirable. Computer literacy is necessary.

If interested, please send your CV and three references to:
Sabina Signoretti M.D.
Department of Pathology
Brigham and Women's Hospital
Thorn Building 504A
75 Francis Street
Boston, MA 02115
617-525-7437 (phone)
ssignoretti@partners.org

 

Whited Lab at Brigham and Women’s Hospital Regenerative Medicine Center
A postdoctoral position is available to start June 1, 2013, or soon thereafter, in a new laboratory forming at the BWH Regenerative Medicine Center.  The laboratory will be investigating the mechanisms that enable axolotl salamanders to regenerate limbs.  We are embarking on an important stage in understanding longstanding questions relating to salamander regeneration as we now have several powerful modern tools that can be used to study these processes.  Particular projects are focused on cellular heterogeneity, encoding of positional information, and the role of vasculature, among others.  This position offers an exciting opportunity to be a part of a newly forming research center at BWH while interfacing with the large regenerative medicine community at Harvard and its affiliated hospitals.

Requirements:  A PhD or equivalent in Biology or a related topic.  Special consideration will be given to candidates with a strong background in molecular biology, virology, and/or genetics.  Experience with computational biology is preferred.  Experience with in vitro cell culture systems is helpful.  Experience with axolotls or other amphibians is not expected.

Please contact Dr. Jessica Whited via email (jwhited@genetics.med.harvard.edu) and include a PDF with current CV, description of past research and future research interests, and contact information for three references. 

Ivanov Lab at Brigham and Women’s Hospital
Our group focuses on understanding physiologic dynamics and the mechanisms of control and interaction of physiological systems, where we utilize concepts and methods from statistical physics and nonlinear dynamics. Our studies have shown that physiologic fluctuations carry important information of diagnostic and prognostic value, and that physiological systems are controlled by feedback mechanisms and exhibit emergent properties across space and time scales, similar to certain physical systems characterized by scale-invariant behavior. We investigate how physiologic dynamics change under different physiologic states (such as sleep stages, circadian phases, levels of physical activity) and under pathologic perturbations. Our research encompass several physiologic systems, separately and in their interaction – from the cellular and molecular length scales to the system level – with the aim to understand how the macroscopic signal outputs emerge from intrinsic microscopic interactions.

We seek a post-doctoral fellow to join our team who will participate in ongoing projects on physiologic and brain dynamics related to sleep and sleep-stage transitions, and to develop new research initiatives. These projects will primarily involve nonlinear time series analysis of multi-channel recordings with focus on empirical findings, as well as on modeling the role of different neuronal groups in sleep regulation by applying novel approaches derived from the theory of complex networks.

The Division of Sleep Medicine is interdisciplinary, and the successful candidate will be encouraged to collaborate within and outside the Division as they pursue their research interests. The rich environment of the Division of Sleep Medicine (http://sleep.med.harvard.edu) offers many opportunities for career development and education.

The candidate will have strong knowledge of statistical physics methods, nonlinear dynamics and nonlinear time series analysis, data processing, and modeling of complex networks. Computational and programming skills are essential. A background in physics, biomedical engineering or applied mathematics is desirable. The initial appointment will be for 1 year, renewable annually thereafter.

Interested candidates should send a letter of interest, curriculum vitae, and contact information for three references in electronic format to:
Plamen Ch. Ivanov, PhD, DSc
Division of Sleep Medicine
Brigham and Women’s Hospital
221 Longwood Ave
Boston, MA 02115
Email: PIVANOV@partners.org or plamen@buphy.bu.edu

 

Wu Lab at Children's Hospital Boston
Dr. Hao Wu at Boston Children’s Hospital (BCH) and Harvard Medical School in Boston, MA, is seeking a post-doctoral fellow to study the molecular mechanism of signal transduction by immune receptors. The successful applicant should have a strong background in molecular biology, biochemistry, and structural biology, such as X-ray crystallography and electron microscopy. Additional experiences with tissue culture and cell biology are encouraged. For more details of the lab, please see our website at http://labs.idi.harvard.edu/wu/.

The successful candidate will join a multi-disciplinary research team of biochemical scientists and actively participate in the on-going research activities of the lab. The candidates will be encouraged to develop their own independent and collaborative research. The post represents an excellent opportunity for an individual to develop his/her career and interact with leading scientists from around the world.

Applicants should have a strong interest in understanding how macromolecular interactions mediate the transmission of signals from receptors to effectors to direct innate immune responses. The successful candidates will develop vigorous research programs. It is expected that close collaborative relationships with other members of the lab, BCH, and Harvard Medical School will be established.

We seek a highly motivated individual with a Ph.D. degree in biochemistry and related fields, with less than 3 years of postdoctoral experience. The applicant should possess good communication skills. Please send your curriculum vitae to Sarah Gusky Kemer (Sarah.GuskyKemer@childrens.harvard.edu), Research Administrator to Dr. Hao Wu. BCH is an Equal Opportunity Employer.

 

Sharma Lab at Joslin Diabetes Center
A postdoctoral position is available immediately at Joslin Diabetes Center, to study pancreatic development and differentiation of endocrine cells. The candidate will work in an exciting and stimulating environment, and participate in determining the role of pancreatic transcription factors in specification, maturation and function of beta cells. We seek a highly motivated, creative, well-organized individual with training in Cell & Developmental Biology with strong experience in working with transgenic/knockout mouse models; experience in studying embryonic development of GI organs and histology, as well as examining metabolic status of mice is highly desirable. The candidate should possess excellent communication skills.

To apply, please contact or e-mail a cover letter, CV and contact information of three references to:
Arun Sharma, Ph.D.
Joslin Diabetes Center
One Joslin Place
Boston, MA 02215
arun.sharma@joslin.harvard.edu

 

Research Fellow at Massachusetts General Hospital (NO FRINGE BENEFITS)
Research in the Endocrine Unit focuses on metabolic bone diseases and mineral metabolism and ranges from trials of novel therapies for osteoporosis to use of genetically altered mice and cell biology to understand the factors that influence calcium and phosphate metabolism.

Responsibilities: A postdoctoral position is available for an NIH-funded project to investigate the roles of stimulatory G protein and its variants in mediating the bone and renal actions of parathyroid hormone. Responsibilities include performing in vivo and in vitro experiments for the characterization of various mouse models and cells obtained from those models. Techniques include, but are not limited to, routine transgenic and knockout mice husbandry, quantitative RT-PCR, western blot and immunohistochemistry.

Requirements: Applicants should have an MD and/or PhD in Physiology, Pharmacology, Molecular Biology, Cell Biology or a related field. Candidates should be highly motivated and creative, with a strong work ethic and the ability to work independently as well as in collaborative research efforts. Proficiency in basic research methods including tissue culture, Western, Northern and Southern blots, immunohistochemistry and immunoprecipiation, and experience with mice, are requirements. Strong knowledge of G protein coupled receptor regulation and signaling and mineral ion metabolism is highly desirable.

Application Instructions: Please e-mail application with curriculum vitae, statement of research interests, and names, phone numbers and email addresses to: Murat Bastepe, MD, PhD, Associate Professor of Medicine, Massachusetts General Hospital and Harvard Medical School. Email: bastepe@helix.mgh.harvard.edu

 

Postdoctoral Research Opportunities in Oral Health Research at the Forsyth Institute
We are currently seeking talent post-docs to join us in our mission of improving oral and overall health. Postdoctoral training is a major strength at Forsyth, and is funded, in part, by a T32 Institutional Postdoctoral Training award, supported by NIDCR. Our program is seeking highly committed, research-career oriented postdoctoral applicants. Support is available for up to three years. Training is available for (a) dentists, with or without the PhD, who seek to obtain collaborative, multidisciplinary research training (basic, translational, or clinical) applicable to oral and craniofacial diseases, conditions and disorders and (b) PhD’s who desire to develop careers in oral health research that will take advantage of the most current scientific and collaborative strategies.

Trainees must be US citizens or hold the “green card” at the time of appointment. Interested individuals should complete the application, send a current curriculum vitae, a description of research interests, contact information for three references, and the name of the desired Forsyth laboratory/mentor to:
Dr. Thomas Van Dyke, Program Director
tvandyke@forsyth.org

 

Yu Lab at The Forsyth Institute
The laboratory of Dr. Qing Yu at the Department of Immunology and Infectious Disease, the Forsyth Institute, has an immediate opening for a postdoctoral fellow to study the function of cytokines and T cells in the pathogenesis of autoimmune diseases, particularly Sj?gren’s syndrome and inflammatory bowel disease.

For more information, please visit the website of Qing Yu lab:   http://www.forsyth.org/research/scientists/profiles/qyu.html

The Forsyth Institute is a world’s leading oral health research institution. It is affiliated to Harvard School of Dental Medicine and located in Cambridge, Massachusetts, in close vicinity to MIT and the Harvard University.
The candidate should have a Ph.D. in immunology or a related field, and have considerable knowledge and skills in both cellular and molecular immunology.  Proficient skills in multi-color flow cytometry, live mouse handling and injections, DNA cloning, gene over-expression and silencing in lymphocytes/immune cells, immunofluorescence and confocal microscopy, real-time PCR analysis of gene expression, in vitro stimulation and functional assays of lymphocytes or other immune cells, and ELISA are required. Previous experience in studying cellular and molecular mechanisms involved in immune-mediated diseases is preferred.  Candidates who obtained their Ph.D. within the last three years are preferred. 

Interested individuals should send CV (including a summary of research skills, publication list and contact information for 2-3 references) to:   qyu@forsyth.org

 

Chen Lab at Massachusetts Eye and Ear Infirmary
A full-time funded post-doctoral Research Fellowship position is currently available at the Massachusetts Eye and Ear Infirmary, which houses the Department of Ophthalmology for the Harvard Medical School.

The Massachusetts Eye and Ear Infirmary is seeking a PhD applicant who will help to investigate novel methods of 3-dimensional imaging of the eye. The successful postdoctoral candidate will be appointed through the Harvard Medical School and will be based at the Massachusetts Eye and Ear Infirmary. Founded in 1824, Mass Eye and Ear is an international leader in ophthalmology research. Because Mass Eye and Ear is a specialty hospital which provides outstanding patient care for disorders of the eye, this provides an outstanding environment for translational research in ocular imaging. Collaboration will be with the researchers who developed spectral domain optical coherence tomography and swept source imaging, and these researchers are currently in Europe and at the Wellman Center for Photomedicine at the Massachusetts General Hospital.

This position will focus on image processing of 3-dimensional images of the eye. The goal of our research is to validate novel methods of analyzing 3-dimensional ocular images that will be useful for the clinical care of patients. Three-dimensional imaging data has already been collected on over 1,000 patients who have been seen at Mass Eye and Ear.

Requirements: Applicants should have a PhD in engineering, physics, or computer science. Individuals with a PhD in the biomedical sciences or who have extensive experience in image processing are also encouraged to apply.

To apply, please send a detailed CV, a cover letter, and the names and contact information of three references. Email is preferred. Please address correspondence to:
Teresa C. Chen, MD
Associate Professor of Ophthalmology
Harvard Medical School
Massachusetts Eye and Ear Infirmary
Glaucoma Service
243 Charles Street
Boston, MA 02114
teresa_chen@meei.harvard.edu
www.masseyeandear.org

 

Battinelli Lab at Brigham and Women’s Hospital
Dr. Elisabeth Battinelli currently has an open position in her lab for a postdoctoral fellow.The Battinelli lab focuses on cancer biology, with a particular interest in how platelets can mediate angiogenesis and impact malignancy through impaired tumor growth and metastasis. The lab employs a number of research tools, including, cell biology, gene expression analysis, immunofluorescence abd confocal microscopy, and flow cytometry to tackle clinically relevant questions. Together with collaborators, we are translating many of their findings to the clinic. Interested candidates should provide cover letter, curriculum vitae with 3 references.

Please contact:
Dr. Elisabeth M. Battinelli , M.D./Ph.D.
Harvard Medical School
Division of Hematology
Brigham and Women’s Hospital
ebattinelli@partners.org

 

Chiocca Lab at Brigham and Women’s Hospital
A postdoctoral position is available immediately to study functions of microenvironment of brain tumors (chiefly glioblastoma multiforme). Our laboratory is focused on several aspects of GBM biology including tumor microenvironment (cell-cell interaction, secretome, exosomes), migration/invasion, gene expression (non-coding RNA, chromatin remodeling), glioma stem cell and therapy resistance. Projects will involve a combination of molecular genetic and cellular based manipulations of glioma cells and stem cells, intracranial glioma models in mice. We offer excellent training opportunities in a collaborative research environment including molecular biology, stem cell biology, gene delivery to brain tumors and imaging.

Candidates for this position must have a Ph.D. (or equivalent) in the biomedical sciences. Preference will be given to applicants with an experimental background in molecular and cellular biology and neuro-oncology, a strong publication record, and excellent communication/interpersonal skills. Previous experience working with mice and computer literacy (including bioinformatics and statistics) are highly desirable. Please email curriculum vitae, a cover letter describing their past research experience, career goals and potential future research interests, and complete contact information for two or three references to Dr. E. Antonio Chiocca at EACHIOCCA@PARTNERS.ORG

Relevant publications: Cancer Research (2008), 68(22):9125-30 (PubMed); Journal of Neuro-Oncology (2009),92(3):297-306 (PubMed); Cell Death and Differentiation (2010), 17(2):221-8 (PubMed); Molecular Cell (2010), 37(5):620-32 (PubMed); Nature Cell Biology (2011),14(2):159-67 (PubMed).

 

The Social Cognitive and Affective Neuroscience (SCAN) Lab at McLean Hospital
The Social Cognitive and Affective Neuroscience (SCAN) Laboratory at McLean Hospital, a Teaching Affiliate of Harvard Medical School, has a post-doctoral fellowship position open immediately in functional and structural neuroimaging analysis.  Our lab is currently funded to conduct several studies using functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), voxel-based morphometry (VBM), and magnetic resonance spectroscopy (MRS) in healthy normal volunteers and individuals with traumatic brain injury.  We are seeking a candidate with an exceptional background in data analysis and signal processing.  A Ph.D. in neuroimaging, neuroscience, and/or related field is required.  Preference will be given to candidates with strong backgrounds in computational methods used in neuroimaging (e.g., Matlab, UNIX, LINUX, C/C++, SPM, AFNI, Freesurfer, FSL) and experience writing/scripting Matlab code.  Exceptional skills in experimental design, quantitative methods, statistical modeling, and the ability to carry out independent data entry and sophisticated statistical analyses using standard software packages (e.g., SPSS, BMDP, JMP, SAS) are particularly desirable.  The successful candidate must demonstrate solid mastery of written English, preferably with some evidence of peer-reviewed publications.

The interested candidate should send a letter of interest, CV, and three letters of recommendation to:
William D. “Scott” Killgore, Ph.D.
Assistant Professor of Psychology
Harvard Medical School
Neuroimaging Center
McLean Hospital
115 Mill Street
Belmont, MA 02478
Email: Killgore@mclean.harvard.edu

Kuhn Lab at Children's Hospital Boston
We have advanced a new mechanistic model for growth and regeneration of the heart (Kuhn et al., Nature Medicine 2007, 8:962-969; Bersell et al., Cell 2009, 138:257-270). We are looking for post-docs for two research projects:
1.) Taking a chemical biology approach to direct differentiation and proliferation of heart muscle cells, cardiomyocytes. The project involves a cell-based screen of chemicals for the capacity to control cardiomyocyte differentiation and proliferation. This project is funded by the Harvard Stem Cell Institute and will be performed collaboratively between the Kuhn (http://kuhnlab.tchlab.org/) and Rubin labs (http://www.scrb.harvard.edu/lab/54/home). Experience and a strong interest in cell and chemical biology should be present. Skills in live cell imaging and screening are an advantage, including: quantitative image analysis, biology of cell division and proliferation, advanced statistics, computational science, and mathematical modeling.

2.) Molecular programs of cardiomyocyte proliferation. This project involves isolation and characterization of regenerating cardiomyocytes using next-generation sequencing. Experience using molecular biology techniques (microarrays, sequencing), isolation of cells using FACS, and functional characterization of genes in cell culture systems is an advantage. This project is NIH-funded.

We are searching for applicants with excellent academic performance and first-author publications. Both projects are multi-disciplinary and involve experts from diverse fields of research. Excellent collaborative and communication skills in English are therefore essential. The selected applicants will be appointed as post-doctoral associate at Boston Children’s Hospital and post-doctoral research fellow at Harvard Medical School.

Interested applicants should send a cover letter, a CV, a summary of previous research experience, a one-page statement of research interests and plans, and three letters of reference to 1.) Chemcardregen@gmail.com, 2.) Profiling@gmail.com, and indicate for which position they apply.

Biddinger Lab at Children's Hospital Boston
Applications are now being accepted for a Post-Doctoral Research Fellow position in the Biddinger lab in the Division of Endocrinology at Boston Children's Hospital. The goal of our research program is to determine how insulin resistance promotes the development of atherosclerosis, gallstones and other components of the metabolic syndrome. This will include projects designed to elucidate the signaling pathways, molecules and mechanisms by which insulin regulates lipid metabolism. A multidisciplinary approach combining biochemistry, cell biology, animal and human studies is employed. Applicants with prior experience in lipid and lipoprotein metabolism are encouraged to apply. Relevant publications: Cell Metab. 2012;in press; Cell Metab. 2008;7(2):125-34; Nat Med. 2008;14(7):778-82; Curr Opin Lipidol. 2009;20(3):206-10.

For further information, please see our website: www.biddingerlab.org

To apply, email a cover letter, curriculum vitae, statement of research experience and career goals, and contact information for three references to sudha.biddinger@childrens.harvard.edu

Piao Laboratory at Childrens Hospital Boston
A postdoctoral position is available to study preplate neurons in cortical development and malformation using mouse genetics, biochemistry, and array analysis. Applicants should be accomplished in biochemistry, molecular biology, and developmental neuroscience. Experience in biochemistry, histology, and mouse brain development would be especially desirable.

Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Xianhua Piao, M.D.,  Ph.D.
Newborn Medicine
Department of Neurology
F.M. Kirby Neurobiology Center
Harvard Medical School

Email: xianhua.piao@childrens.harvard.edu
Web Site: http://childrenshospital.org/cfapps/research/data_admin/Site598/mainpageS598P0.html

Postdoctoral Position at Hebrew Senior Life Institute for Aging Research
Postdoctoral fellowship position opportunity for MD and/or PhD with minimum 2 years research  experience and academic background in geriatric medicine, internal medicine, gerontology, psychiatry, neurology, neuropsychology, cognitive disorders, and clinical epidemiology. Candidates will have in-depth knowledge of epidemiological and biostatistical techniques, and less than 5 years of postdoctoral experience. An established publication record is preferable. Strong interpersonal and communication skills are required. The candidate will interact with a large research team including senior epidemiologists, biostatisticians, and clinicians. Areas of interest include: risk factors and interventions for delirium, the interrelationship of delirium, dementia, and other age-related cognitive disorders, advanced measurement methods for delirium assessment, and biomarker discovery for delirium.

US citizenship or permanent resident status required. Hebrew SeniorLife, Beth Israel Deaconess Medical Center, and Harvard Medical School are equal opportunity employers, women and minorities are encouraged to apply.

Interested candidates: please email cover letter and curriculum vitae to Dimple Shah at: dimpleshah@hsl.harvard.edu

Xavier Laboratory at Massachusetts General Hospital
A postdoctoral position is currently available in Dr. Ramnik Xavier’s research group to join an exciting initiative that aims at integrating findings from human disease genetics with novel approaches in functional genomics and chemical biology to make progress towards treatments for Crohn’s disease. Our multidisciplinary team is based at both the Center for Computational and Integrative Biology (MGH) and the Broad Institute.

Qualifications: The ideal applicant will have a PhD or MD/PhD in the areas of immunology, cell biology, or molecular biology. A strong publication record, excellent communication skills and ability to work in a team are essential. Experience in working with genetically engineered mice is a plus.

Please send a cover letter, CV, and the names and email addresses of three references to Kelly Clarke (kaclarke@partners.org).

Xavier Laboratory at Massachusetts General Hospital
A postdoctoral position in the area of novel therapeutics for type 1 diabetes is currently available in Dr. Ramnik Xavier’s research group in the Center for Computational and Integrative Biology (MGH) and Broad Institute. The goal of this multidisciplinary project is to integrate findings from human disease genetics with novel approaches in functional genomics and chemical biology to make progress towards treatments for type I diabetes.

Qualifications: The ideal applicant will have a PhD or MD/PhD in the areas of immunology, cell biology, or molecular biology. A strong publication record, excellent communication skills and ability to work in a team are essential. Experience in working with genetically engineered mice is a plus.

Please send a cover letter, CV, and the names and email addresses of three references to Kelly Clarke (kaclarke@partners.org).

Lehtinen Laboratory at Childrens Hospital
A postdoctoral position is available to study the role of cerebrospinal fluid-based signaling in neural stem cells as it relates to the developing nervous system and disease. Techniques used in the lab involve primarily mouse genetics, imaging, next gen sequencing, biochemistry, and in vitro assays. Applicants should be accomplished in biochemistry, molecular biology, cell biology, and familiar with mouse work. Experience in the characterization of proteins in signaling pathways would be especially desirable. Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:

Maria Lehtinen, Ph.D.
Department of Pathology
Children’s Hospital Boston
Harvard Medical School
Email: maria.lehtinen@childrens.harvard.edu

Kaye Lab in Tumor Virology at Brigham and Women’s Hospital
The Kaye laboratory at Brigham and Women's Hospital/Harvard Medical School has a postdoctoral position available. The laboratory investigates the molecular basis of Kaposi’s sarcoma herpesvirus (KSHV or human herpesvirus 8) mediated oncogenesis using a combination of approaches in molecular biology, cell biology, biochemistry, and chemical biology. Projects are available in viral persistence and all aspects of pathogenesis. A strong background in molecular biology or biochemistry is preferred.

Please send or email curriculum vitae and names of three references (with contact information for references) to: Dr. Kenneth Kaye, Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Ave., Boston, MA 02115 email: kkaye@rics.bwh.harvard.edu

 

Letvin Laboratory at Beth Israel Deaconess Medical Center
Postdoctoral positions are available in the laboratory of Dr. Norman Letvin, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, for highly motivated scientists with a Ph.D. or M.D. degree and an interest in viral immunology.  The laboratory develops and uses animal models for exploring early events in the immunopathogenesis of AIDS and for developing novel vaccination strategies to prevent HIV infection.  Preference will be given to candidates with skills in molecular virology and/or molecular and cellular immunology.

Interested candidates should e-mail their CVs with full contact information of at least 3 references to: letvinlab@gmail.com

The Beth Israel Deaconess Medical Center is an equal opportunity employer.  Minorities and women are especially encouraged to apply.

Contact:          Norman L. Letvin, M.D.
                        Beth Israel Deaconess Medical Center
                        330 Brookline Avenue
                        E/CLS-1043
                        Boston, Massachusetts 02215

Karmacharya Laboratory at Massachusetts General Hospital
A postdoctoral fellow position is available in the MGH Center for Human Genetic Research to study induced pluripotent stem cell (iPSC)-derived neuronal cells from patients with schizophrenia and bipolar disorder to identify disease signatures by using chemical biology and functional genomics approaches. The overall goal is to discover cellular signatures for schizophrenia and bipolar disorder in iPSC-derived neurons using phenotypic and gene expression studies. Signature-based high-throughput screens will then be used to identify novel small molecule probes to investigate the disease biology of schizophrenia and bipolar disorder and to provide leads for therapeutic development. The project entails close collaboration with the Chemical Biology Program at the Broad Institute of Harvard and MIT. The fellow will have simultaneous academic appointments at the Massachusetts General Hospital and Harvard Medical School.

Qualifications: PhD in neurobiology, molecular biology, or related field required. Must have 1-2 years experience in working with stem cells and have demonstrated expertise in the use of fluorescence microscopy, flow cytometry, cellular imaging/microscopy, and molecular biology (RT-PCR, cloning, immunoprecipitation, western blotting). Additional expertise in the use of RNA interference and viral vectors preferred.

Candidates should include an updated CV, complete contact information for three references, and a cover letter describing their past research experience, career goals and potential future research interests. Applicants should send materials to: Rakesh Karmacharya, MD, PhD karmacharya@mcb.harvard.edu

Luo Laboratory at Childrens Hospital Boston
Postdoctoral positions are available at Harvard Medical School and Children's Hospital Boston to study signal transduction in innate immune system.  We are looking for highly motivated individuals with a Ph.D.  If interested, please send a CV, a statement of research interests, as well as the names and contact information for three references to:

Dr. Hongbo R. Luo, Associate Professor
Department of Pathology and Lab Medicine
Harvard Medical School and Children's Hospital
811 Enders Building, 320 Longwood Avenue
Boston, MA 02115
Phone: 617-919-2303   
e-mail: Hongbo.Luo@childrens.harvard.edu

Shaw Laboratory at Massachusetts General Hospital
Postdoctoral fellow positions are available in the MGH Center for Systems Biology (Shaw laboratory; http://csb.mgh.harvard.edu/shaw) to use chemical biology and functional genomics approaches to discover and modulate therapeutic targets in human disease. The laboratory’s overall goal is to understand how susceptibility alleles or disease mutations contribute to disease, and to translate these insights into novel therapies or biomarkers. Experimental approaches range from wet lab experiments, to high-throughput chemical screens, to bioinformatic data mining of Electronic Medical Records (EMR). Disease areas under investigation include cardiovascular disease, type 2 diabetes, mitochondrial disease, and inflammatory bowel disease. This position is based in the Simches building on the main MGH campus. The postdoctoral fellow will enjoy close collaborations with MGH clinician-researchers and investigators at the MGH Center for Human Genetics Research and the Broad Institute of Harvard and MIT. The fellow will have simultaneous academic appointments at the Massachusetts General Hospital and Harvard Medical School.

Requirements: M.D. and/or Ph.D. degree. Applicants who are students in their final year of their Ph.D. studies, or about to undertake research as part of their medical specialty training are preferred. Experience in any of the following disciplines is strongly preferred: chemical biology, systems biology, human genetics, functional genomics, high-throughput screening, epigenetics, or bioinformatics. Research experience involving cell and molecular biology techniques, and/or mammalian tissue culture required. U.S. citizen or permanent resident (green card) strongly preferred; this position will not sponsor an H-1B application. Candidates should include an updated CV, complete contact information for three references, and a cover letter describing their past research experience, career goals and potential future research interests.

Applicants should sent materials to: Dr. Stanley Shaw, shaw.stanley@mgh.harvard.edu

Sahay Laboratory at Massachusetts General Hospital
The Sahay laboratory (http://www.massgeneral.org/regenmed/staff/) is interested in understanding how stem cell and neural circuit based plasticity mechanisms in the adult brain may be harnessed to modify hippocampal functions in cognition and mood and how alterations in neural circuits contribute to the development of psychiatric disorders. We are currently seeking to fill two postdoctoral positions. Potential candidates must be highly self-motivated and enthusiastic about taking on new challenges. Projects will involve a combination of molecular genetic and viral based manipulations of neural circuits and stem cells, physiology and behavioral assays in mice. Preferred candidates should have demonstrated research productivity, independent thinking and rigorous training in molecular, behavioral, developmental or systems neuroscience. Candidates with a strong background in other fields (eg. molecular biology, immunology, neuropharmacology) are also welcome to apply. Interested candidates should send their resume/CV and the names and 3 reference letters to Dr. Amar Sahay (Sahay.Amar@mgh.harvard.edu).

Candidates will have access to state-of-the-art lab and core facilities within MGH and HSCI and will be part of a stimulating and vibrant academic environment of basic and translational biomedical sciences.

Pollak Laboratory at Beth Israel Deaconess Medical Center
The Pollak lab at Harvard Medical School and Beth Israel Deaconess Medical Center in Boston is seeking motivated postdoctoral fellows to work on projects related to the genetic basis of human kidney disease. Our lab uses genitic mapping, RNA expression analyses, and DNA sequence analyses to identify genes and gene variants responsible for kidney phenotypes in humans. We also use animal models to assist our studies of phenotypes and molecular and cell biological tools to understand the functions of disease genes. Applicants should have experience with computational genomics, and/or molecular and cell biological techniques. The ideal applicant will have experience in both computational and laboratory methods.

In addition a strong background and an ability to work in team settings is essential. Please submit a letter detailing your research motivations, what your specific interests are, and a CV with names of three references to Jeannie Minnelli (jminnell@bidmc.harvard.edu).

Pittet Laboratory at Massachusetts General Hospital
A position is open in the Pittet lab at Massachusetts General Hospital – Harvard Medical School, Boston, USA (http://csb.mgh.harvard.edu/pittet). The project focuses not only on the role that immune cells play in cancer development, invasion and metastasis, but also on how these cells can be harnessed for therapy. The effects of anticancer drugs on immune host cell networks are currently poorly understood. Yet, having such knowledge would be invaluable toward advancing current therapeutic strategies. Here, we will exploit innovative approaches to investigate the real-time effects of therapeutics on immune responses in vivo with the goal to reevaluate anticancer treatment options.

The candidate (PhD or MD) must be a US citizen or green card holder. S/he should have extensive experience in cell and molecular immunology, a strong publication record, and excellent communication skills. Interested individuals should submit a cover letter, including a brief description of research experience and interest, a CV, and contact information for two references to: sdlaft@mgh.harvard.edu.

Recent publications: Mempel et al. Immunity. 2006;25:129; Swirski et al. PNAS USA. 2006;103:10340; Pittet et al. Nature Protoc. 2006;1:73; Swirski et al. J Clin Invest. 2007;117:195; Nahrendorf et al. J Exp Med. 2007;204:3037; Pittet et al. PNAS USA. 2007;104:12457; Pittet et al. Immunol Rev. 2008;221:107; Weissleder et al. Nature. 2008;452:580; Cortez et al. J Clin Invest. 2008;118:4058; Swirski et al. Science. 2009;325:612

Ivanov Laboratory, Division of Sleep Medicine, Brigham & Women’s Hospital
Our group focuses on understanding physiologic dynamics and the mechanisms of control and interaction of physiological systems, where we utilize concepts and methods from statistical physics and nonlinear dynamics. Our studies have shown that physiologic fluctuations carry important information of diagnostic and prognostic value, and that physiological systems are controlled by feedback mechanisms and exhibit emergent properties across space and time scales, similar to certain physical systems characterized by scale-invariant behavior. We investigate how physiologic dynamics change under different physiologic states (such as sleep stages, circadian phases, levels of physical activity) and under pathologic perturbations. Our research encompass several physiologic systems, separately and in their interaction – from the cellular and molecular length scales to the system level – with the aim to understand how the macroscopic signal outputs emerge from intrinsic microscopic interactions.

We seek a post-doctoral fellow to join our team who will participate in ongoing projects on physiologic and brain dynamics related to sleep and sleep-stage transitions, and to develop new research initiatives. These projects will primarily involve analysis of multi-channel recordings with focus on empirical findings, as well as modeling the role of different neuronal groups in sleep regulation applying novel complex networks approaches.

The Division of Sleep Medicine is interdisciplinary, with members from backgrounds in physiology, psychology, medicine, applied mathematics and physics, and the successful candidate will be encouraged to collaborate within and outside the Division as they pursue their research interests. The rich environment of the Division of Sleep Medicine (http://sleep.med.harvard.edu) offers many opportunities for career development and education. The candidate will have knowledge of data processing, nonlinear time series analysis and networks modeling. A background in physics or biomedical engineering is desirable. The initial appointment will be for 1 year, renewable annually thereafter.

Interested candidates should send a letter of interest, curriculum vitae, and contact information for three references in electronic format to:
Plamen Ch. Ivanov, PhD, DSc
Division of Sleep Medicine
Brigham and Women’s Hospital
221 Longwood Ave Boston, MA 02115
Email: PIVANOV@partners.org

The Wirth Laboratory at the Harvard School of Public Health
The Wirth laboratory at the Harvard School of Public Health has openings for two Postdoctoral Scientists. The group is engaged in using genome-wide sequencing to identify genetic loci associated with important and clinically relevant phenotypes such as drug response, or that are under recent positive selection using population genetic approaches. The successful candidates (2) will be involved in either exploring patterns and associations of gene expression in clinical malaria samples to parasite phenotypes, vector/host preferences and disease outcomes; or in the functional follow up and biological validation of loci identified using genome wide sequencing approaches to both understand the role of these biological loci and clinical phenotypes and to leverage mutations
identified as important in these processes as molecular biomarkers to track parasites in field settings.

Please send a letter of application, including a statement of current and future research interests; curriculum vitae, including current and past grant support; sample publications; and the names of
three recommenders to the address below. Recommenders will not be contacted until candidates have completed the initial review phase. Electronic submission of application documents to the
email below is preferred. Email: harvardmalariainitiative@hsph.harvard.edu

 

The Frangioni and Choi Laboratories at Beth Israel Deaconess Medical Center
The Frangioni and Choi Laboratories of the Center for Molecular Imaging at Beth Israel Deaconess Medical Center, Harvard Medical School, seek talented and self-motivated post-doctoral fellows with strong backgrounds in organic chemistry, radiochemistry, and/or medicinal chemistry. Our mission is to solve important clinical problems by applying first principles from chemistry and engineering. The major focus of our laboratories is on the development of imaging contrast agents to see cancer at its smallest possible manifestation. This post-doctoral fellowship position will focus on developing new chemical entities for use as contrast agents for NIR fluorescence, PET, SPECT, and/or MRI imaging. Applicants must have a Ph.D. in organic chemistry and high-quality, first author, peer-reviewed publications in the field. Applicants will be responsible for developing novel fluorophores and radiolabeling of cancer-specific ligands for image-guided cancer targeting and surgery. Applicants will be trained in in vivo molecular imaging techniques as needed. Working in the Frangioni and Choi Lab places you in the center of the Longwood Medical Area of Harvard Medical School, with access to superb human and technical resources. From the training provided by the laboratory, current and previous fellows have built strong careers in the field of molecular imaging. Although the laboratory is always seeking to expand its pool of talented researchers, we give priority consideration to self-funded fellows. We also require a two-year commitment to the laboratory.

Apply online here: https://prod.fadvhms.com/bidmc/JobBoard/JobDetails.aspx?__ID=*F3FB35DB00A4AB22

The Center for Molecular Imaging at Beth Israel Deaconess Medical Center
The Frangioni and Choi Laboratories of the Center for Molecular Imaging at Beth Israel Deaconess Medical Center, Harvard Medical School, seek talented and self-motivated post-doctoral fellows with strong backgrounds in organic chemistry, radiochemistry, and/or medicinal chemistry. Our mission is to solve important clinical problems by applying first principles from chemistry and engineering. The major focus of our laboratories is on the development of imaging contrast agents to see cancer at its smallest possible manifestation. This post-doctoral fellowship position will focus on developing new chemical entities for use as contrast agents for NIR fluorescence, PET, SPECT, and/or MRI imaging. Applicants must have a Ph.D. in organic chemistry and high-quality, first author, peer-reviewed publications in the field. Applicants will be responsible for developing novel fluorophores and radiolabeling of cancer-specific ligands for image-guided cancer targeting and surgery. Applicants will be trained in in vivo molecular imaging techniques as needed. Working in the Frangioni and Choi Lab places you in the center of the Longwood Medical Area of Harvard Medical School, with access to superb human and technical resources. From the training provided by the laboratory, current and previous fellows have built strong careers in the field of molecular imaging. Although the laboratory is always seeking to expand its pool of talented researchers, we give priority consideration to self-funded fellows. We also require a two-year commitment to the laboratory.

Apply online here: https://prod.fadvhms.com/bidmc/JobBoard/JobDetails.aspx?__ID=*EF0F05023EF4E4B2

The Chaikof Lab at Beth-Israel Deaconess Medical Center
NIH funded postdoctoral position available in the areas of biomaterials and tissue engineering in the laboratory of Dr. Elliot Chaikof at Harvard Medical School and the Wyss Institute of Biologically Inspired Engineering at Harvard University (wyss.harvard.edu/viewpage/224). This research project is aimed at the design, fabrication, and in vitro and in vivo assessment of bio-inspired artificial blood vessels. The incumbent will work collaboratively to construct artificial blood vessel prototypes from composite biomaterials. Micro-fabrication techniques will be applied to dictate structure and resulting macro-scale properties. Experience in tissue engineering, micro-fabrication, the design of animal experiments, mammalian cell culture, and prototyping are a plus. A Ph.D. in Biomedical Engineering or a related field is required.

Submit CV and three references to jcaves@bidmc.harvard.edu.


Lemon Lab in the Department of Molecular Genetics, Forsyth Institute
A post-doctoral fellowship position is available in the laboratory of Dr. Katherine Lemon. We are seeking an enthusiastic person to pursue research on human upper respiratory tract microbiome with a focus on the nose and throat. The position is ideal for someone just finishing a Ph.D. who would like to start with a well-defined project that is in progress. A Ph.D. and research experience is required. Qualified applicants will possess strong skills in microbial ecology, environmental microbiology, human microbiome, or bioinformatics. Experience in 16S rRNA-based community composition analysis and analysis of community WGS or metagenomic data is highly desirable.

The laboratory is in the Department of Molecular Genetics, The Forsyth Institute (a Harvard affiliate), located at 245 First Street in Cambridge, MA 02142. The Forsyth Institute is at the forefront of research in oral, craniofacial and related sciences and is well known for research on human oral microbiome. Postdoctoral researchers have Harvard appointments at the Harvard School of Dental medicine. Our benefits package includes health, dental and vision insurance, tuition reimbursement and flexible spending accounts.

Please email a cover letter, curriculum vitae, and contact information for three references to Dr. Katherine Lemon at klemon@forsyth.org. The position is available to start between now and September 1, 2011. The salary will be commensurate with experience. Affirmative Action/Equal Oppty Employer M/F/H/V

Yu Lab in the Department of Immunology, Forsyth Institute
A postdoctoral fellow position is available in the laboratory of Dr. Qing Yu in the Department of Immunology at the Forsyth Institute, Cambridge, MA. The Forsyth Institute is one of the world’s leading research institutes in oral, craniofacial and related sciences and is affiliated with Harvard School of Dental Medicine and Harvard Medical School. The overall research interest in the laboratory is to study the molecular mechanisms governing the differentiation and function of Tregs and T helper cell subsets and the role of these T cells in oral/dental related autoimmunity, inflammation and host defense. For example, one aim seeks to understand the control of Treg and T helper cell differentiation and function by transcription factors TCF1 and beta-catenin (Yu, et al, Nature Immunology, 2009, 10(9):992).

Applicants should have a Ph.D in Immunology or a related field and a strong background in cellular immunology and molecular biology. Excellent skills in cell culture, flow cytometry, immunohistochemistry, current molecular biology techniques and working with mice are required. Experience in oral biology/dental medicine research is preferred.

This position will begin in early November, 2010. Interested applicants should send their curriculum vitae (including a brief summary of research experience and bibliography) and contact information for 3 references to qing.yuq@hotmail.com.


Haggarty and Perlis' Lab at Mass General Hospital
We are looking to recruit a highly motivated postdoctoral research fellow to join a multidisciplinary translational research group focusing on developing innovative neural stem cell models to enable the investigation of the molecular and cellular basis of neuropsychiatric disorders and the response to mood stabilizers, antidepressants, and antipsychotics. The Chemical Genomics Laboratory (S. Haggarty, PI) and the Laboratory of Psychiatric Pharmacogenomics (R. Perlis, PI) are part of the Center for Human Genetics, one of 5 thematic centers at the Massachusetts General Hospital/Harvard Medical School and are also closely integrated with the Stanley Center for Psychiatric Research at the Broad Institute. The focus will be on the development of patient-specific neural stem cells from existing and newly generated induced pluripotent stem (iPS) to enable the characterization of disease genes and pathways implicated in the etiology and pathophysiology of mental illness using small-molecule probes and molecular genetic approaches. In addition, the project will involve the integration of results with ongoing clinical studies aiming to develop novel therapeutics for the treatment of mood disorders. This is a unique opportunity for working in a fast-paced, and highly collaborative, translational research group working at the interface of chemistry, biology, and therapeutic development.

Qualifications: PhD in neurobiology, neuropharmacology, cell biology, or related field required. Must have 1-2 years experience in working with stem cells and have demonstrated expertise in the use of fluorescence microscopy, flow cytometry, cellular imaging/microscopy, and molecular biology (RT-PCR, cloning, immunoprecipitation, western blotting). Additional expertise in the use of RNA interference and viral vectors preferred. Prior work with small molecules and familiarity with high-throughput screening, including automated microscopy and plate readers, a plus. Must posses excellent computer skills and be able to perform quantitative analysis of large data sets. Advanced statistics or programming skills a plus. Excellent critical thinking skills and attention to detail needed. Must be able to use sound judgment to effectively solve problems, work independently, and handle a variety of tasks. Requires effective oral and written communication skills along with meticulous laboratory technique and recording skills.

Interested applicants should send cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:

Stephen Haggarty, Ph.D.
Center for Human Genetic Research
Massachusetts General Hospital/Harvard Medical School
185 Cambridge Street, Boston, MA 02114
Email: haggarty@chgr.mgh.harvard.edu
Web Site: http://www.mgh.harvard.edu/neurology/research/haggarty_stephen.aspx
http://www2.massgeneral.org/chgr/faculty_perlis.htm
http://www.broadinstitute.org/psych/stanley

Postdoctoral Research Opportunity at the Institute for Aging Research
The Institute for Aging Research, a division of Hebrew SeniorLife, is seeking an MD or PhD with strong research potential and a commitment to an academic career in aging research, for a 2 year research fellowship focused on cerebrovascular and/or neuromuscular mechanisms of falls. The fellow will join a productive clinical laboratory investigating cerebral blood flow regulation, vascular function, postural control, gait, and aging in a multidisciplinary research institute affiliated with Harvard Medical School. They will have access to a large population database containing extensive longitudinal data on risk factors for falls. They will participate in weekly laboratory meetings, conferences, and collaborative projects at the Institute for Aging Research, Beth Israel Deaconess Medical Center and other Harvard-affiliated teaching hospitals. This position is supported by an NIA-funded T32 National Research Service Award devoted to training in translational research in aging. The Award provides salary support, course tuition, a travel stipend, and opportunities for loan forgiveness. Citizenship Status: This Program is funded by a grant from the National Institute on Aging and requires that the candidate be a US citizen or permanent resident and remain in the program for 2 years. If you were born outside of the USA, please provide a notarized copy of your proof of US citizenship or permanent resident status.

Interested candidates should apply online at www.HSLCareQuest.com. To learn more about the Institute for Aging Research, go to www.hebrewseniorlife.org/research.

Shah Lab at Mass General Hopital
Postdoctoral research position is available immediately in Molecular Neurotherapy and Imaging Laboratory at Massachusetts General Hospital and Harvard Medical School. Our laboratory focuses on engineering stem cell based regulatable pro-apoptotic and antiangiogenic therapies for gliomas. Inherently linked to the brain tumor therapy paradigm, we employ fluorescent/bioluminesecent imaging markers and optical imaging techniques to image stem cell fate and monitor the effect of therapeutic proteins delivered to brain tumors. In an effort to develop combination therapies and sensitize glioma cells to therapeutic stem cells, we are also interested in altering the EGFR/PI3K/AKT signaling pathway that is frequently overactive in high grade gliomas.

Applicants should have a PhD degree or equivalents, with experience in one or more of the following techniques such as stem cell biology, gene cloning, vector construction and animal surgeries. We offer excellent training opportunities in a collaborative research environment including molecular biology, stem cell biology, gene delivery to brain tumors and imaging disciplines.

Please submit resume and list of two references, addressed to Dr. Khalid Shah, by email to: kshah@helix.mgh.harvard.edu

Weissleder Lab at Mass General Hopital
We are looking to recruit a highly motivated postdoctoral research fellow to join a very dynamic research effort focussing on cardiovascular molecular imaging. The laboratory is part of the Center for Systems Biology, one of 5 thematic centers at the MGH and of the Center for Molecular Imaging Research, both headed by Dr. Ralph Weissleder.

Research interests of our group focus on 1) imaging of molecular processes during the healing phase after myocardial infarction, 2) imaging of heart transplant rejection, and 3) imaging of inflammation in atherosclerotic plaques. Imaging targets are enzymes, innate immune cells and molecular players with a central role in cardiovascular disease. We use the entire spectrum of modalities, including MRI, nuclear and optical imaging techniques. These technologies are embedded in a biologically driven research program that aims at systematic understanding of inflammation and repair at a basic level while keeping a rigorous translational perspective.

Responsibilities: after a training period, the successful applicant will self-reliantly plan and conduct experiments and will be involved in writing scientific manuscripts.

Requirements: experience in cell culture, flow cytometry and molecular biology techniques as well as a strong interest in innate immunity, imaging and cardiovascular pathophysiology.  Successful applicants have a strong publication record, creative thinking and good team spirit. Due to funding restricitions, only US citizens or green card holder will be considered.

Serwold Lab at the Joslin Diabetes Center
A postdoctoral position is open in the Serwold laboratory at the Joslin Diabetes Center, Harvard Medical School. The Serwold lab is focused on the processes that drive the development of normal and autoimmune T cells. Specific projects focus on identifying and characterizing the stem and progenitor cell populations that develop into the T cell and epithelial cell lineages within the thymus, and determining the role of Major Histocompatibility Complex molecule-mediated peptide presentation by these cells in the development of normal and autoimmune T cells. Successful applicants will have expertise in immunology, developmental biology or other related area of research. Send CV and 3 references to Tom Serwold: Thomas.serwold@joslin.harvard.edu.

Weissleder Lab at Mass General Hospital
Several post-doctoral position are available in the laboratory of Ralph Weissleder, MD, PhD, Director of the MGH Center for Systems Biology. The laboratory’s overall goal is to understand how human biology and disease unfolds in vivo. We utilize unbiased approaches such as high-throughput chemical screens and profiling, combined with advanced imaging capabilities and traditional molecular and cell biology techniques. Available positions are:
a) chip based detection cancer cells (Nat Med. 2008;14(8):869-74)
b) nanomaterials and bioconjugation (Angew Chem Int Edit. 2009;48:5657 60)
c) chemical biology to develop imaging agents (Nature 2008;452:580-589)
d) mathematical modeling of cell trafficking (Science. 2009;325:612-6)
e) intravital imaging of mitosis and apoptosis in cancer (Nature  2008;452:580-589)

The Center for Systems Biology is located within the new Simches building on the main MGH campus, and features a dynamic, multi-disciplinary environment with close interactions with MGH clinician-researchers and investigators across Harvard and MIT. The Fellow will have simultaneous academic appointments at the Massachusetts General Hospital and Harvard Medical School.

Requirements: M.D. or Ph.D. degree, or students in their final year of their Ph.D. studies. Experience in any of the following disciplines is strongly preferred: cancer biology, cell biology, microscopy, immunology bioinformatics, mathematical modeling. U.S. citizen or permanent resident (green card) and outstanding publication record required. Candidates should include an updated CV, complete contact information for three references, and a cover letter describing their past research experience, career goals and potential future research interests.

Gynecologic Oncology at Brigham and Women's Hospital
A postdoctoral position is available in the Laboratory of Gynecologic Oncology, in the Department of Obstetrics, Gynecology and Reproductive Biology at Brigham and Women’s Hospital, Harvard Medical School, under the direction of Drs. Alex Ng, Ph.D., and Ross Berkowitz, MD. Candidates should have a Ph.D. degree with a strong background in cell signaling and molecular biology. Experience in mouse models and stem cell research is particularly desirable. Applicants are invited to send curriculum vitae, summary of research interests and experience, and three references to: Dr. Alex Ng (sng@partners.edu). Brigham and Women's Hospital and Harvard Medical School are Equal Opportunity Employers.

Babitt Lab at Mass General Hospital
A funded postdoctoral research fellow position is available in the Babitt laboratory at MGH. We are part of the Program in Membrane Biology, Division of Nephrology and Center for Systems Biology located in the new Simches Research Center adjacent to the MGH main campus. The goal of our research program is to understand the molecular and cellular mechanisms involved in iron homeostasis and to develop new therapeutic strategies to treat disorders of iron homeostasis such as anemia of chronic disease and hemochromatosis. We employ a multidisciplinary approach including biochemistry, molecular and cell biology, and animal studies.

Selected References
1) Andriopoulos B Jr, Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietrangelo A, Vukicevic S, Lin HY, Babitt JL. Nat. Genet. 2009 Apr;41(4):482-7.
2) Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B Jr, Lin HY, Pietrangelo A, Babitt JL.Gastroenterology. 2009 Oct;137(4):1489-97.
3) Babitt et al. J Clin Invest. 2007 Jul;117(7):1933-9.
4) Babitt et al. Nat Genet. 2006 May;38(5):531-9.

Candidates for this position must have a Ph.D. (or equivalent) in the biomedical sciences. Preference will be given to applicants with an experimental background in biochemistry, molecular and cellular biology, and/or genetics, a strong publication record, and excellent communication/interpersonal skills. Please email a cover letter, CV, and the names, telephone numbers, and email addresses of three references to Babitt.jodie@mgh.harvard.edu

Wang Lab at Brigham and Women's Hospital
A Postdoctoral Fellow position in Department of Neurosurgery, Brigham and Women's Hospital/Harvard Medical School available immediately for a project on the neuroprotective drugs against Amyotrophic Lateral Sclerosis. We are seeking motivated candidate with a PhD degree. The successful candidate is highly expected to have significant experience in the study of Amyotrophic Lateral Sclerosis including mSOD1 G93A transgenic mice, and hold publications in the field in peer-reviewed scientific journals. Salary is commensurate with experience. Full benefits included. Positions will start as soon as possible.

Applications should include comprehensive curriculum vitae, list of publications, and contact information of 3 referees. Please email all materials to Assistant Professor Xin Wang email: xwang@rics.bwh.harvard.edu
Website: http://www.brighamandwomens.org/research/Xin_Wang/default.asp

Selected papers: 1. The antiapoptotic activity of melatonin in neurodegenerative diseases. CNS Neurosci Ther. 2009; 15(4):345-57. 2. Methazolamide and melatonin inhibit mitochondrial cytochrome c release and are neuroprotective in experimental models of ischemic Injury. Stroke. 2009; 40(5):1877-85. 3. Nortriptyline delays disease onset in models of chronic neurodegeneration. Eur J Neurosci. 2007; 26(3):633-41. 4. Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. Proc Natl Acad Sci U S A. 2003; 100(18):10483-7.

MassGeneral Institute for Neurodegenerative diseases (MIND)
The MassGeneral Institute for Neurodegenerative diseases (MIND) Informatics group is seeking a highly motivated, innovative and independent computational biologist to work with an interdisciplinary team of researchers at the Harvard Stem Cell Institute (HSCI). The successful candidate will conduct computational research and analyses on multimodal data (e.g. microarray, proteomics) to gain a better understanding of the self-renewal, maintenance and differentiation process of embryonic, hematopoietic and leukemia stem cells. The candidate will be expected to research and develop novel computational and statistical methods; implement robust reusable tools that conform to community standards; interact with software engineers on team; work cooperatively with various members of HSCI; publish actively and present results.

The candidate should have a recent PhD in science or engineering. The successful candidate should have demonstrated strength in a computational science such as physics, statistics, mathematics or bioinformatics and have a strong background in biology. Good programming skills in R, S-PLUS or SAS and firsthand experience in processing microarray or other biological datasets are necessary. Knowledge of stem cell biology is preferred. The ability to work independently, sincere interest in learning new concepts and skills and high motivation are prerequisites.

Women and minority candidates are encouraged to apply--MGH/HMS is an affirmative action employer.

Contact:
Sudeshna Das, PhD
Massgeneral Institute for Neurodegenerative diseases, MGH
65 Landsdowne Street, Cambridge MA 02139
sudeshna_das@harvard.edu

Wang Lab at Harvard School of Dental Medicine
A postdoctoral position is available in Xiu-Ping Wang’s laboratory in the Department of Developmental Biology, Harvard School of Dental Medicine.  Our lab uses a combination of cellular and molecular approaches to study the molecular genetics of craniofacial and tooth development.  Our current emphasis is on the understanding of the role of Wnt signaling in embryonic tooth development and supernumerary tooth formation.  In addition, we also use the continuously growing mouse incisor as a model to study adult stem cells and stem cell regulations.

We are interested in candidates with a strong publication record and background in developmental biology, molecular biology, genetics, and cell biology with experience in using cell culture, fluorescence microscopy and animal experimental approaches.  Please email a cover letter, CV, and the names and email addresses of three references to Dr. Xiu-Ping Wang: xpwang@rics.bwh.harvard.edu

Silberstein's Laboratory at Children's Hospital Boston
Applications are now being accepted for a Post-Doctoral (M.D. or Ph.D.) Research Fellow position.The goal of our research program is to characterize bone marrow niche-induced signaling pathways controlling normal and neoplastic progenitor B-cell development and function.  A multidisciplinary approach combining immunology, biochemistry, cell biology, animal study, and imaging is employed.

For more information, please see the following website: http://www.childrenshospital.org/cfapps/research/data_admin/Site188/mainpageS188P0.html

To apply, email a cover letter, curriculum vitae, statement of research experience and career goals, and contact information for three references addressed to Dr. Leslie Silberstein, Director Joint Program in Transfusion Medicine. Emails should be sent to Daniella Geanuracos, Administrative Assistant, at Daniella.Geanuracos@childrens.harvard.edu


Department of Radiology at the Beth Israel Deaconess Medical Center
A full time post-doctoral Research Fellowship position is currently available at the Division of MRI Research, Department of Radiology at the Beth Israel Deaconess Medical Center, Harvard Medical School. Research is focused on the development of new techniques and applications using CEST and PARACEST agents. The project will include development of new pulse sequences, image analysis and theoretical models development. The position requires PhD in physics, chemistry, biology or the related field. The ideal candidate will have strong MRI or NMR background. Experience with pulse programming (GE or Bruker)  is not mandatory, but would be of advantage.

Applicants are invited to send CV and the contact information of 2-3 references to Dr. Elena Vinogradov: evinogra@bidmc.harvard.edu.


The Lahav Lab at Brigham and Women’s Hospital
A postdoctoral research fellow position is available in the Department of Newborn Medicine at Brigham and Women’s Hospital at Harvard Medical School. Our research is focused on developing innovative ways to measure and optimize brain development of critically ill newborns, with a special interest in the effect of the hospital sound environment on neuro-developmental outcomes. For more information please see our Lab website. Applicants (M.D. or Ph.D.) should have a strong background in clinical research. Experience in neonatal/pediatric brain imaging and/or auditory neuroscience is especially desirable.

Please send a copy of your CV, and names and contact information of three references to Dr. Amir Lahav (amir@hms.harvard.edu).


Sharma Lab at Joslin Diabetes Center
A postdoctoral position is available immediately at Joslin Diabetes Center, to study pancreatic development and differentiation of endocrine cells. The candidate will work in an exciting and stimulating environment, and participate in determining the role of pancreatic transcription factors in specification, maturation and function of beta cells. We seek a highly motivated, creative, well-organized individual with training in Cell & Developmental Biology with strong experience in working with transgenic/knockout mouse models; experience in studying embryonic development of GI organs and histology is highly desirable. The candidate should possess excellent communication skills.

To apply, please contact or e-mail a cover letter, CV and contact information of three references to:
Arun Sharma, Ph.D.
Joslin Diabetes Center
One Joslin Place
Boston, MA 02215
arun.sharma@joslin.harvard.edu



Anderson Lab at Beth Israel Deaconess Medical
Postdoctoral Fellow needed with strong molecular biology skills to recreate genetic forms of human autism and epilepsy using BAC recombineering, ES cell homologous recombination, and mouse transgenics. Target the disease gene to specific cell-types using Cre recombinase/loxP technologies (Anderson et al. 2005 PNAS). Use recombineered epitope tags to isolate and characterize the native protein complexes associated with these disease gene proteins (BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods. 2008 5:409-15). An MD and/or PhD degree and extensive prior experience with molecular biology and proteomics techniques are required.

Contact: Matthew P. Anderson M.D., Ph.D. (mpanders@bidmc.harvard.edu)


Claudio Vinegoni at Mass General Hospital
The Center for Systems Biology at the Massachusetts General Hospital/Harvard Medical School has an immediate opening for a Post-doctoral Research Fellow within the In-Vivo Microscopy Core.

This Core laboratory focuses on the development of optical imaging techniques for molecular imaging with biomedical and biological applications. The candidate should have hands-on experience in one or more of the following: optical instrumentation development, biomedical optics, optical microscopy (confocal and multiphoton, FRET, Raman), optical spectroscopy, fiber based microscopy. Exceptional experience in multiphoton mouse imaging is required. Proficiency in programming using C++, Matlab and Labview are a benefit. Applicant should present a strong publication record and demonstrate independence in research.

We offer excellent training opportunities in a highly collaborative research environment including molecular biology, system biology, stem cell biology, cardiovascular disease, cancer and imaging disciplines. The candidate will be engaged on multiple collaborative projects.

Requirements: Applicants should have a PhD degree or equivalent in one of the following disciplines: Applied Physics/Biophysics, Biological Sciences, Optical Engineering, Biomedical Engineering with a strong background in different optical imaging techniques; in particular, in-vivo multiphoton microscopy.

All interested applicants should submit a CV and two letters of reference to Dr. Claudio Vinegoni cvinegoni(at)mgh.harvard.edu http://csb.mgh.harvard.edu/information/careers#post_15

Further Information
Excellent command of spoken and written English is essential in all positions. Positions are ONLY available to US CITIZENS AND PERMANENT RESIDENTS. Competitive academic salaries. Ability to keep good records and work independently is essential. MGH is an equal opportunity employer.


Sun Hur Laboratory at the Immune Disease Institute (IDI)
A post-doctoral position is available to study the molecular mechanism for self vs. non-self discrimination by the innate immune system. We use a combination of X-ray crystallography, biochemistry and cell biology to characterize structures and functions of key host molecules that recognize foreign molecules, in particular viral nucleic acids.

Applicants should have received a PhD or MD and have a strong background in X-ray crystallography, biochemistry, cell biology or virology.

Please send a cover letter, CV, names, e-mail addresses and telephone numbers of three references to Sun Hur (hur@idi.harvard.edu)

Lab website: http://idi.harvard.edu/labs/hur


Rohit N. Kulkarni, MD, PhD Laboratory at Joslin Diabetes Center
Funded Postdoctoral position available immediately to study stem cell biology and cell fate specification of pancreatic islet cells.

Our laboratory utilizes cell biological, genetic and genomic approaches to identify and characterize stem and progenitor cell populations in adult tissues.  Particular interests include specification and function of pluripotent and tissue-specific stem cells in mice (JEM 202:1599, 2005; Cell 116:639, 2004; Nature 441:1109, 2006), and molecular signals governing pancreatic beta cell growth (Nat Genet 38:583, 2006; PNAS 104:8977, 2007).  Current projects are aimed at derivation and directed differentiation of normal and disease-specific induced pluripotent (iPS) stem cells along endocrine lineage, specifically insulin-secreting beta cells. These studies will be relevant for both type 1 and type 2 diabetes.

Seeking qualified individual interested in characterizing cell lineages and precursor populations in adult pancreas and identifying factors that influence growth/expansion of beta cells.  Successful candidate will have strong background in developmental, stem cell biology and endocrinology.  Prior experience with flow cytometry, microscopy, ES cell culture and mouse handling desirable.

Send brief statement of research interests, CV, and names of three references to: Lindsay.huse@joslin.harvard.edu


Rohit N. Kulkarni, MD, PhD Laboratory at Joslin Diabetes Center
Funded postdoctoral position available immediately to work on beta cell regeneration using mouse models and cell biology approaches.

We utilize cell and molecular biological, genetic and genomic approaches to dissect and define cellular and molecular mechanisms that underlie beta cell regeneration and apoptosis.  Particular interests include exploring the role of the growth factor and leptin signaling pathways in the replication of beta and alpha cells. (Nat Genet 38:583, 2006; PNAS 104:8977, 2007; JCI 117:2860, 2007).  Current projects are aimed at creating and phenotyping novel mouse models with a focus on proteins that are involved in beta/alpha cell cycle control and molecular signals governing pancreatic islet cell growth. The long term goals are aimed at therapeutic approaches to treat type 1 and type 2 diabetes.

Seeking qualified individual interested in dissecting the mechanisms of beta/alpha cell regeneration using mouse and human islets and beta cells.  Successful candidate will have strong background in molecular biology, biochemistry, and endocrinology.  Prior experience with creating transgenics, ES cell culture, mouse handling and microscopy desirable.

Send brief statement of research interests, CV, and names of three references to: Lindsay.huse@joslin.harvard.edu


Qin Laboratory at the Laboratory for Translational Research
Our laboratory is interested in understanding the role of complement system in the pathogenesis of human diseases such as atherosclerosis and cancer. We generate a variety of CD59 knockout and human CD59 transgenic mice. We are looking for self-motivated, bright and independent individuals with a MD or PhD in any area of biomedical sciences to define the cellular and molecular mechanisms of complement in the pathogenesis of atherosclerosis. Experience in cardiovascular disease, protein chemistry, singling transduction or immunology is a plus.

A competitive salary and an excellent work environment will be provided. Please send your most current CV and contact information for three references to the following address:

Xuebin Qin, MD, PhD
Laboratory for Translational Research
Harvard Medical School
One Kendall Square, Building# 600, 3rd Floor
Cambridge, MA 02139
Email: xuebin_qin@hms.harvard.edu


Wei Laboratory at Beth Israel Deaconess Medical
A postdoctoral position is available in the Wei Lab at Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School starting immediately. The lab’s focus is on understanding how Ubiquitin E3 ligase APC and SCF activities contribute to cell cycle regulation and subsequent tumor formation. Future projects in the lab engage the use of biochemistry, molecular biology and genetic approaches, cell culture techniques and potentially mouse modeling. Therefore, energetic applicants with strong experimental background in biochemistry, molecular and cellular biology and/or genetics are encouraged to apply.

Dr. Wei is looking for self-motivated individuals to become involved in the challenging and rewarding environment of the laboratory. If interested, please send your CV/resume and at least two references to:

Wenyi Wei, PhD
Dept. of Pathology, Harvard Medical School
Beth Israel Deaconess Medical Center
Research North Room 243
99 Brookline Avenue
Boston, MA 02115
Phone: (617) 667-0272
Email: Wwei2@bidmc.harvard.edu


Dr. Jing-Wei Xiong's Laboratory at Massachusetts General Hospital
A NIH-funded postdoctoral fellowship is available to investigate zebrafish cardiovascular development in Dr. Jing-Wei Xiong's Lab in the Department of Medicine/Nephrology at Massachusetts General Hospital. Our overall goals are to identify vascular endothelial and endocardial progenitors and determine the molecular signaling pathways underlying their formation and differentiation using cellular, molecular, genetic and imaging analysis. The primary interest is to determine a newly discovered gene lysocardiolipin acyltransferase in vascular endothelial and endocardial lineages development in zebrafish (Xiong et al., 2008. Circ Res 102:1057-1064; Wang et al., 2007. Blood 110, 3601-3609; Xiong, 2008. Dev Dyn 237:1218-1231). Other projects are studying cardiovascular development using several ENU-induced cardiovascular mutants in zebrafish.

Preference will be given to highly motivated PhD and/or MD applicants who recently graduated with strong background in molecular and developmental biology and have peer-reviewed publications in their fields. Candidates need to be either a permanent resident or American citizen due to the funding source. Interested candidates may send their CV and references to:

Jing-Wei Xiong, Ph.D.
Assistant Professor of Medicine
Department of Medicine/Nephrology
Massachusetts General Hospital-East
149 13th Street, Room 8216
Charlestown, MA 02129
Phone: (617) 726-6583
Fax: (617) 726-5669
Email: xiong@cvrc.mgh.harvard.edu


LINKS TO HELP IDENTIFY ADDITIONAL OPPORTUNITIES

Beth Israel Deaconess Medical Center (BIDMC)
Postdoctoral positions for basic research in a range of departments at BIDMC.

Brigham and Women's Hospital (BWH)
Postdoctoral positions for basic research in a range of departments at Brigham and Women's Hospital.

The Cardiovascular Research Center (CVRC) at MGH
The MGH Cardiovascular Research Center is dedicated to advancing human health through fundamental scientific investigations into the mechanisms of cardiovascular disease and related metabolic disorders.

Center for Blood Research (CBR)
The Center for Blood Research is an independent medical research center focusing on inflammation and the immune response, located on the Harvard Medical School Quadrangle.

Children's Hospital Boston (CHB)
Postdoctoral positions for basic research in a range of departments at CHB.

The Forsyth Institute
The Forsyth Institute studies the underlying causes of oral diseases.

The Joslin Diabetes Center
The Joslin Diabetes Center is an internationally known clinical and research center and an affiliate of Harvard Medical School. Joslin’s training program - the largest diabetes specific training program in the world - prepares the next generation of basic and clinical researchers in diabetes with more than 120 MD and PhD fellows in training each year. Trainees are able to learn basic and advanced scientific techniques from morphology to genetics, genomics and proteomics and to expand their horizons by being exposed to the latest advances in basic science and clinical research in diabetes.

Harvard School of Public Health (HSPH)
Positions are currently available for post-docs with a variety of backgrounds, including genetics, epidemiology and biostatistics.

McLean Hospital
McLean Hospital is an affiliate of Massachusetts General Hospital and a member of the Partners HealthCare System, Inc., which allows for comprehensive coordination of medical and psychiatric services. A major teaching facility of Harvard Medical School, McLean Hospital maintains the largest program of research in neuroscience and psychiatry of any private psychiatric hospital in the United States.

Molecular Vision Training Program
A postdoctoral ophthalmology training program with faculty drawn from all over the Harvard vision community including Mass Eye and Ear, Mass General Hospital, Brigham and Women's Hospital, Harvard Medical School, Schepens Eye Research Institute and Harvard University.

Partners Healthcare System
Includes Brigham and Women's Hospital and Massachusetts General Hospital. Use the search engine to search for Job Category: Research Fellows and Postdocs.

Program in Membrane Biology
The Program in Membrane Biology at the Massachusetts General Hospital East laboratories in the Charlestown Navy Yard has postdoctoral positions available in the general area of membrane protein trafficking.