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DEPARTMENTAL LISTINGS

BIOLOGICAL CHEMISTRY AND MOLECULAR PHARMACOLOGY

Eggert Lab
A postdoctoral position is available to study mechanisms of cell division. We are a new lab that uses chemistry and biology to probe cytokinesis. We take a comprehensive approach combining biohemistry, cell biology, RNAi and chemical genetics. One of our goals is to generate small molecule tools, identify their cellular targets and then use the tools to interrogate biological mechanism.

Individuals with an interest in interdisciplinary research are invited to apply. Please send a cover letter, CV, and names, e-mail addresses and telephone numbers of three references to Ulrike Eggert.


Walter Lab
Post-doctoral position available to study the molecular mechanisms underlying the initiation of eukaryotic DNA replication. A powerful cell-free system has been developed which supports cell-cycle regulated chromosomal DNA replication in completely soluble protein extracts (Walter et al., 1998, Molecular Cell, 1, 519). Projects include identifying novel initiation activities, characterizing the biochemical steps involved in initiation, and understanding how initiation is regulated during the cell cycle.

A strong background in biochemistry or molecular biology is required. Send a cover letter, CV, and names, e-mail addresses and telephone numbers of three references to:

Dr. Johannes Walter
BCMP
Harvard Medical School
240 Longwood Ave
Boston, MA 02115


CELL BIOLOGY

The Liberles Lab
A postdoctoral research position is available to study the molecules and neural circuits that govern instinctive animal behavior. We focus on (1) a novel family of mammalian olfactory receptors and (2) neural populations in the hypothalamus that control mouse feeding behavior.

Applicants should have an excellent record of scientific achievement and be highly skilled in molecular biology or neuroscience techniques. Candidates should send a CV, a description of research interests, and a list of three references (by e-mail) to:

Stephen Liberles, Ph.D.
Department of Cell Biology
Harvard Medical School
240 Longwood Avenue
Boston, MA 02115


The Reck-Peterson Lab
A postdoctoral position is available to study the mechanisms underlying cell division and intracellular transport. We use single molecule biophysical approaches combined with genetics and biochemistry to understand the role of microtubule-based motors in these processes.

A strong background in biophysics and biochemistry is required. Potential candidates should send a PDF including a cover letter, curriculum vitae that includes a list of publications, and the names, email addresses and phone numbers of three references to:

Samara Reck-Peterson, Ph.D.
Department of Cell Biology
Harvard Medical School
240 Longwood Avenue
Boston, MA 02115


GENETICS
No positions currently listed.


MICROBIOLOGY AND MOLECULAR GENETICS

The Hochschild Lab
Postdoctoral position available to study transcription mechanism and regulation in bacteria. Cellular transcription depends on a multi-subunit RNA polymerase, which is conserved from bacteria to man. Using a variety of genetic tools developed in the laboratory, including a transcription-based bacterial two-hybrid assay, we are probing events that occur during transcription initiation, elongation and termination, as well as the ways in which regulatory factors modulate these events (Nickels et al., 2006, Molecular Cell 24: 457; Leibman and Hochschild, 2007, EMBO J 26: 1579). Another project in the laboratory is focused on the development of E. coli-based assays to study the potentially pathogenic protein-protein interactions that mediate the formation of prion-like protein aggregates.

A strong background in molecular biology/biochemistry is required. Please e-mail cover letter, CV, and names of 3 references with complete contact information to:

Ann Hochschild, Ph.D.
Department of Microbiology and Molecular Genetics
Harvard Medical School
200 Longwood Avenue
Boston, MA 02115


NEW ENGLAND PRIMATE RESEARCH CENTER
No positions currently listed.


NEUROBIOLOGY

The Gu Lab
Postdoctoral positions are available to study the molecular mechanisms of axon and vascular wiring during development, adulthood and disease. Join an exciting new lab in Goldenson that in the past has developed several genetically engineered mouse models to demonstrate that neuronal and vascular morphogenesis is tightly interwoven molecularly (Gu et al.,2005, Science. 307 (5707) 265-268; Gu et al., 2003 Developmental Cell. 5 (1):45-57). These works and others have opened an exciting field of research on dynamic interactions between the nervous and vascular systems. We are now focused on understanding their intimate anatomical and functional relationships and will take a comprehensive approach combining mouse genetics, cell biology, biochemistry, and imaging modalities to uncover these mechanisms. Ultimately, we aim to know how neural and vascular networks are coordinately developed, communicate, and evolve to work together.

Highly motivated Individuals with an enthusiastic interest in our research program are invited to apply. Please email or send a cover letter, CV, as well as 3 reference names, e-mail addresses and telephone numbers to:

Chenghua Gu, D.V.M., Ph.D.
Harvard Medical School
220 Longwood Avenue
Boston, MA 02115
Fax: 617-734-7557


Cohen Lab
A postdoctoral position is available in the Department of Neurobiology, Harvard Medical School, to study the mechanisms of activation and inhibition of nicotinic acetylcholine receptors and GABAA receptors. Projects include the use of biochemical techniques and the electrophysiological analyses of mutant receptors to identify changes in receptor structure between closed, open, and desensitized states and to identify binding sites for novel allosteric modulators of receptor function.

Applicants should have recently received a PhD and have a strong background in biochemistry and/or expression and functional characterization of mutant proteins.

Applicants should send a cover letter, CV, and the names, e-mail addresses and telephone numbers of three references to:

Dr. Jonathan Cohen
Neurobiology
Harvard Medical School
220 Longwood Avenue
Boston, MA 02115


PATHOLOGY

Bonni Lab
A postdoctoral research fellow position is immediately available to study mechanisms of brain development and disease. We aim to identify key cell-intrinsic genetic programs and regulatory pathways that control neuronal connectivity in the developing mammalian brain. We are also interested in determining how deregulation of these fundamental mechanisms contributes to the pathogenesis of neurological diseases. For background information on the approaches used, see the following papers (Konishi et al. Science 2004; Shalizi et al. Science 2006; Lehtinen et al. Cell 2006) and our laboratory website: http://pathology.hms.harvard.edu/labs/bonni/index.html.

Interested candidates must hold Italian citizenship and have strong background in molecular biology and biochemistry. A cover letter and curriculum vitae should be sent by email together with the names of three referees with contact information to:

Azad Bonni, M.D., Ph.D.
Department of Pathology
Harvard Medical School
77 Avenue Louis Pasteur
Boston, MA 02115


Haigis Lab
The Haigis laboratory in the Department of Pathology at Harvard Medical School has an opening for a Postdoctoral Scientist. The focus of the laboratory is to study the role of mitochondria in aging and metabolism. Various projects are available, involving studies of transgenic mouse models, microarray analysis, and drug design. Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry or a related field. Training in biochemistry, cell biology, or metabolism is highly desirable.

Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference to:

Marcia C. Haigis, Ph.D.
Harvard Medical School
Department of Pathology
NRB, Room 954
77 Avenue Louis Pasteur
Boston, MA 02115


Khosravi-Far Lab
Postdoctoral position available to participate in studies on the molecular mechanism of human malignancies with an emphasis on the signal transduction pathways that regulate cell growth and cell death. Our approaches combine in vitro biochemical, molecular and cell biological studies with in vivo genetic experiments. Current projects include investigating the signal transduction pathways that are critical for selective tumor death by TRAIL cytokine and the analysis of the role of apoptotic factors in carcinogenesis. A strong motivation as well as experience in molecular biology, cell biology, biochemistry and immunology are required.

Applicants should submit their CV, a statement of research interest together with the names of three referees with contact information to:

Roya Khosravi-Far, Ph.D.
Department of Pathology
Harvard Medical School
Beth Israel Deaconess Medical Center
99 Brookline Ave., Rm 270F
Boston, MA 02115


SYSTEMS BIOLOGY
No positions currently listed.


W. ROXBURY VA HOSPITAL

Geller Lab
A Postdoctoral Fellow or Associate Position is available in the Dept. of Neurology at the W. Roxbury VA Hospital/Harvard Medical School. Our laboratory has pioneered a helper virus-free Herpes Simplex Virus (HSV-1) vector system for gene transfer into neurons, and is studying visual learning and developing gene therapy for Parkinson’s disease. We have developed chimeric, neuronal-specific promoters that support long-term expression. Recently, we performed deletion analyses to isolate small fragments that contain the critical regions for long-term expression. This NIH R01 grant-funded position is to isolate the critical genetic elements that support long-term expression, and then elucidate the underlying mechanisms. Recent relevant publications: Journal of Neuroscience, 2005, 25, 8468-81; Brain Research 2007, 1130, 1-16; Brain Research 2007, 1144, 19-32.

The successful candidate will have a strong background in molecular biology and an ability to perform a wide range of procedures such as plasmid constructions, tissue culture, gel shifts, or yeast 1-hybrid screens. A Ph.D. or M.D., research experience, and publications are required. An interest in neuroscience is a plus. A 2-3 year commitment is expected, and there is a possibility for advancement and a long-term position.

Contact: alfred_geller@hms.harvard.edu; Associate Professor



POSTDOC OPPORTUNITIES @ HMS TEACHING AFFILIATES

Beth Israel Deaconess Medical Center (BIDMC)
Postdoctoral positions for basic research in a range of departments at BIDMC.

Brigham and Women's Hospital (BWH)
Postdoctoral positions for basic research in a range of departments at Brigham and Women's Hospital.

The Cardiovascular Research Center (CVRC) at MGH
The MGH Cardiovascular Research Center is dedicated to advancing human health through fundamental scientific investigations into the mechanisms of cardiovascular disease and related metabolic disorders.

Center for Blood Research (CBR)
The Center for Blood Research is an independent medical research center focusing on inflammation and the immune response, located on the Harvard Medical School Quadrangle.

The Forsyth Institute
The Forsyth Institute studies the underlying causes of oral diseases.

The Joslin Diabetes Center
The Joslin Diabetes Center is an internationally known clinical and research center and an affiliate of Harvard Medical School. Joslin’s training program - the largest diabetes specific training program in the world - prepares the next generation of basic and clinical researchers in diabetes with more than 120 MD and PhD fellows in training each year. Trainees are able to learn basic and advanced scientific techniques from morphology to genetics, genomics and proteomics and to expand their horizons by being exposed to the latest advances in basic science and clinical research in diabetes.

Harvard School of Public Health (HSPH)
Positions are currently available for post-docs with a variety of backgrounds, including genetics, epidemiology and biostatistics.

McLean Hospital
McLean Hospital is an affiliate of Massachusetts General Hospital and a member of the Partners HealthCare System, Inc., which allows for comprehensive coordination of medical and psychiatric services. A major teaching facility of Harvard Medical School, McLean Hospital maintains the largest program of research in neuroscience and psychiatry of any private psychiatric hospital in the United States.

Molecular Vision Training Program
A postdoctoral ophthalmology training program with faculty drawn from all over the Harvard vision community including Mass Eye and Ear, Mass General Hospital, Brigham and Women's Hospital, Harvard Medical School, Schepens Eye Research Institute and Harvard University.

Partners Healthcare System
Includes Brigham and Women's Hospital and Massachusetts General Hospital. Use the search engine to search for Job Category: Research Fellows and Postdocs.

Program in Membrane Biology
The Program in Membrane Biology at the Massachusetts General Hospital East laboratories in the Charlestown Navy Yard has postdoctoral positions available in the general area of membrane protein trafficking.