Open Postdoc Positions

Postdoctoral Positions at HMS Quad-based Labs

The Dean's Postdoctoral Fellowship | Therapeutics Innovation Fellowship Program | Curriculum Fellows ProgramBiological Chemistry and Molecular Pharmacology | Biomedical Informatics | Cell Biology | Center for Bioethics | Genetics | Global Health and Social Medicine | Harvard Catalyst | Harvard Program in Therapeutic Science | Health Care Policy | ImmunologyMicrobiology | Neurobiology | Systems Biology | Harvard School of Dental Medicine | Wyss Institute

This page lists some of the postdoctoral positions currently available on the HMS Quadrangle. Many principal investigators do not advertise their postdoctoral positions with us, so if the PI you want to work with isn't listed here, please contact her/him directly. Please do not send your CV to the administrator of this page.
For non-Quad or external positions please see: postdoc.hms.harvard.edu/job-opportunities

Quad Departments: to have an opportunity listed on this page, send along a description of the postdoctoral position and contact information to us HERE. Please direct any questions to postdoc_office@hms.harvard.edu.

Postdoc openings at other Harvard affiliated institutions:
Beth Israel Deaconess Medical Center | Brigham & Women's Hospital | Children’s Hospital | Dana-Farber | Joslin | Mass General Hospital * | McLean Hospital* | T.H. Chan School of Public Health*
*Please note: some Harvard affiliates do not advertise individual postdoc positions with us, it may be best to identify a PI conducting work in your specific area of interest, and to email that PI directly with your CV and cover letter.

- FEATURED FACULTY POSITIONS-

Assistant/Associate Professor, Harvard Medical School, Blavatnik Institute/Life Sciences
Position Description: With a specific goal of advancing diversity in scientific research and discovery, the Blavatnik Institute, located on the quadrangle at Harvard Medical School, invites applications for up to four tenure track Assistant or Associate Professor positions in the life sciences. We are looking for early-career scientists taking molecular and quantitative approaches in the broad fields of biological and biomedical sciences, with a track record of research productivity and a demonstrated commitment to fostering diversity and equity. Departments participating in this initiative include Biological Chemistry & Molecular Pharmacology, Biomedical Informatics, Cell Biology, Genetics, Immunology, Microbiology, Neurobiology and Systems Biology. The search process will include a seminar as well as meetings with faculty and students, after which successful candidates will work with the search committee and school leadership to select an optimal departmental affiliation(s).
The Blavatnik Institute provides numerous technological resources and organized core facilities to stimulate discovery. All Institute departments offer an intellectually rich, career- supportive, and family-friendly environment that promotes creativity, innovation and interdisciplinary research. Because of our commitment to excellence, it is imperative that we foster a diverse faculty. Even if you are not a candidate, please respond by nominating excellent candidates who will enhance the diversity of the Blavatnik Institute through their demonstrated commitment to fostering diversity, equity, and inclusivity. Successful candidates will be part of a cohort of scholars with access to specialized resources and a community of committed mentors dedicated to facilitating career advancement.
Successful candidates will become members of the training faculty in one or more of the Harvard University Ph.D. Programs, such as the umbrella Biological and Biomedical Sciences (BBS) Program, and/or more topic specific programs including: Biophysics; Chemical Biology; Immunology; Microbiology; Neuroscience; Systems, Synthetic, & Quantitative Biology; and Virology, which all attract extraordinary graduate students.
Basic Qualifications: A Ph.D., M.D./Ph.D. or M.D. is required in cellular, molecular, chemical, computational, or physical sciences.
Please apply through the Harvard web portal, complete details and application link:
https://academicpositions.harvard.edu/postings/9760 (posted 9.8.20)

~FEATURED FELLOWSHIP OPPORTUNITIES~

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The Dean's Postdoctoral Fellowship

The Dean’s Postdoctoral Fellowship at Harvard Medical School is a two-year research fellowship established to nurture, advance, and retain a diverse scientific workforce that will continue to contribute to diversity through their ongoing academic and research scholarship.  The fellowship program prepares scientists from groups historically underrepresented in the basic and social sciences for careers in academia and other sectors. Fellows benefit from a highly innovative and creative research environment that emphasizes scientific rigor, collaboration, and the pursuit of excellence in science. 

BENEFITS
The two-year fellowship provides funding in the amount of $50,000/year, and DPF fellows are eligible for Harvard’s generous benefits package. They receive additional opportunities for career enhancement, mentorship, seminars, workshops, and conferences, along with a robust support network, through the Harvard Medical School Scholars in Translational and Academic Research (HMS STARs) program.

ELIGIBILITY

·         Have an MD, MD/PhD, PhD, ScD, or equivalent degree in the basic or social sciences.

·         Have United States citizenship or permanent resident status.

·         Come from a background that is historically underrepresented in the basic and social sciences.

·         Have no more than two years of postdoctoral experience.

ELIGIBLE DEPARTMENTS
Fellows conduct research with faculty within the basic and social science departments at Harvard Medical School. For a list of eligible departments, click here.

APPLICATION PROCESS
The application for the Dean’s Postdoctoral Fellowship is available on the DICP website at www.mfdp.med.harvard.edu/deanspostdoc
Applicants need to submit this form along with a cover letter, CV, and a statement that makes the connection between the mission of the Fellowship and their research interests and professional goals.

RECOMMENDATIONS
Three letters of recommendation are required, one of which must be from the applicant’s thesis advisor. For those who have held a postdoc position, the second letter must be from their postdoc advisor.

DEADLINE
Applications are currently accepted on a rolling basis, with the recommendation that they be submitted at least 4 months ahead of the candidate’s anticipated start date. 

SELECTION
Applications are reviewed by a committee comprised of Harvard Medical School faculty and administrators. Fel­lows are selected on the basis of their demonstrated aca­demic achievement, scholarly promise, commitment to research, potential to add to the diversity of the Harvard Medical School community, and the likelihood that the in­dividual may become an independent scientist and societal leader who, upon the completion of the fellowship, will continue to contribute to diversity through their ongoing academic and research scholarship.

Interested candidates are encouraged to contact Lyn Fulton-John, Program Manager, Dean’s Postdoctoral Fellowship Program at dicp_deanspostdoc@hms.harvard.edu or by phone at 617-432-9051 with any questions they may have.

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THERAPEUTICS INNOVATION FELLOWSHIP PROGRAM

I-Hub, Harvard Medical School - Therapeutics Innovation Fellow for the COVID-19 Translator Research Program
The new Harvard Ideation Hub (I-Hub) is seeking a high-achieving, early-career PhD level scientist with a passion for advancing drug discovery and developing novel therapeutics and medicines to improve human health for a new Fellowship program at Harvard Medical School. The fellow will be responsible for the support of a portfolio of COVID projects, and will work with seasoned industry professionals, consultants and HMS project managers to support projects by monitoring timelines, deliverables, milestones, communications, and budgets and by staffing meetings within The Translator at Harvard Medical School. The mission of the Translator is to accelerate the translation of fundamental science at Harvard Medical School toward the medicines of tomorrow. The Translator is coordinating a series of COVID-19 related therapeutic discovery efforts between academic investigators at Harvard and elsewhere and within the HMS emerging pathogens program.
The Therapeutics Innovation Fellows (TIFs) program is a new training program for PhD trained scientists and post-doctoral fellows whose career goals are in research or project management and grants management. TIFs will assist faculty in project ideation, fundraising, management and commercialization, and when needed, may also participate directly in research. TIFs will devote ~80% effort to service and ~20% to mentored training and an organized curriculum. The TIFs will form a community with other fellows from Therapeutics related programs at Harvard, and will work and learn strategies and tactics in drug discovery and related therapeutic science. The successful candidate will partner closely with project faculty to conceive of, develop, and manage projects, and write funding proposals and white papers for research collaborations and initiatives. This individual will also work with faculty in the community from across Harvard and the Longwood Medical Area to develop new collaborative research proposals and initiatives. This position will report to the Director of Therapeutics Training and Education. More details and apply. (posted 9.8.20)

I-Hub, Harvard Medical School - Therapeutics Innovation Fellow for the Lyme Disease Research Program
The new Harvard Ideation Hub (I-Hub) is seeking a high-achieving, early-career PhD level scientist with a passion for building community, creating powerful events, and advancing therapeutic disease research for a new Fellowship program at Harvard Medical School. The Fellow will work to create a strong, active, and engaged community; create resources; and ideate with HMS faculty at the helm of projects about Lyme disease. The fellow will additionally be responsible for the management of novel programs to advance the understanding of Lyme disease in the area of neuroimmunology.
The Therapeutics Innovation Fellows (TIFs) program is a new training program for PhD trained scientists and post-doctoral fellows whose career goals are in research or project management and grants management. TIFs will assist faculty in project ideation, fundraising, management and commercialization, and when needed, will also participate directly in research. TIFs will devote ~80% effort to service and ~20% to mentored training and an organized curriculum. The TIFs will form a community with other fellows from Therapeutics related programs at Harvard, and will work and learn strategy and tactics in drug discovery and related therapeutic science. The successful candidate will report to the Therapeutics Director of Training and Education, and will partner closely with project faculty to conceive of, develop, and manage projects, and write funding proposals and white papers for research collaborations and initiatives. This individual will also work with faculty in the community from across Harvard and the Longwood Medical Area to develop new collaborative research proposals and initiatives.  More details and apply. (posted 9.8.20)

 

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The Harvard Medical School Curriculum Fellows Program (CFP)

Research Rigor and Reproducibility Curriculum Fellow

Institution: Harvard Medical School | Location: Boston, MA | Category: Faculty - Science | Type: Full Time
The Research Rigor and Reproducibility (R3) initiative at Harvard Medical School (HMS) in Boston, Massachusetts is seeking an innovative, collaborative science educator to serve as R3 Curriculum Fellow (CF). The R3 CF will ­develop teaching curricula, work with faculty to modernize biomedical research training, and support the development and administration of the HMS R3 program. The fellow will be a member the HMS Curriculum Fellows Program (CFP), a postdoctoral training program for biomedical scientists interested in a variety of education-focused careers. CFs work full-time with members of the HMS faculty and administration to develop, deploy, and evaluate evidence-based graduate training while receiving mentorship and career advising to support their development as educators.

Advances in modern biomedical research require the continuous development of and support for a culture that advances research rigor and reproducibility (R3). HMS is committed to identifying, exploring, and supporting R3 principles relevant to our research community through cross-discipline conversations and collaborations. The HMS R3 Committee supports R3 through organizational development, training and educational programs, and resources and tools for our students, trainees, faculty, and staff. The R3 CF will be a critical contributor to those efforts.
Based in the Office for Academic and Research Integrity and working closely with the Office of Research Operations and the Curriculum Fellows Program, the R3 Curriculum Fellow will provide support for the HMS R3 Working Group and Faculty Advisory Committee. The CF will play a key role in developing R3-related curriculum and in cataloguing, developing, implementing, and maintaining HMS resources related to research rigor and reproducibility. Some specific duties and responsibilities of the R3 Fellow will include:

  1. Assisting the R3 committee and R3 Working Group in the planning, implementation, data collection, review, and presentation of an HMS community-wide R3 Preliminary Landscape Analysis
  2. Working with HMS Graduate and Medical Education units, the Office for Postdoctoral Fellows, HMS faculty, and others to expand and develop R3-relevant curricula and training programs at HMS, and to make available some basic R3 course material as online training modules via the Harvard Training Portal
  3. Assisting the R3 committee and R3 Working Group in the development, implementation, and maintenance of the HMS R3 website

Qualifications:

  • An earned Ph.D. in a biomedical science
  • The ability to interact with various R3 stakeholders including faculty at all levels, information technology professionals, and project managers
  • Postdoctoral research or teaching experience (preferred)
  • Demonstrated interest in the metascience of research and data integrity, data management
  • Knowledge of the research data lifecycle in the academic laboratory environment
  •  Job Skills and Competencies:
    Strong interest in keeping up with emerging trends, best practices, and new knowledge in the fields of data management, the research data lifecycle, and information technology
    Ability to engage with faculty, administrators, other researchers, and lab managers to integrate their input and ensure R3 projects fully reflect their directives and priorities
    Strong organizational skills, communication skills (written, oral and presentation); a concern for accuracy, details, and quality
    Tolerance of ambiguity and uncertainty in a constantly evolving field
    Adaptability and ability to prioritize work and to be flexible in job tasks
    Highly self-motivated and directed

The Curriculum Fellow’s appointment is renewable annually for a maximum of three years and is non-tenure-track. The fellowship is intended for early-career scientist-educators, therefore applications from candidates with more than 5 years of postdoctoral research or teaching experience are discouraged. Fellows are appointed as research associates, with possible promotion to the rank of Lecturer, contingent on experience and performance. The R3 Curriculum Fellow position is open for an immediate start. Applications are currently being accepted and reviewed on a rolling basis with the goal of filling the position as soon as possible.
To apply:
Applicants should include a single PDF document containing:

(1) a letter of application that addresses your interest in and qualifications for the position

(2) a curriculum vitae

(3) a teaching statement

(4) the names and contact information of three professional references

Email application materials to cfp@hms.harvard.edu, attention Dr. Bradley Coleman, Director of the HMS Curriculum Fellows Program.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.  (posted 8.18.20)

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Curriculum Fellow in Translational and Biomedical Sciences
Institution: Harvard Medical School | Location: Boston, MA | Category: Faculty – Science | Type: Full Time
The Leder Human Biology (LHB) Program at Harvard Medical School (HMS) is seeking an innovative, collaborative early-career science educator to provide broad curricular and academic support to LHB, a translational medicine certification for HMS biomedical PhD students. The Curriculum Fellows Program is a postdoctoral service and training program focused on curriculum development, teaching, and educational programming in the biological and biomedical sciences at Harvard Medical School (HMS). Curriculum Fellows work closely with members of the HMS faculty and administration to develop, deploy, and evaluate evidence-based graduate training. Fellows also receive mentorship and career advising to support their development as educators and help them succeed in a variety of education-focused careers.
Responsibilities:
- Work closely with the faculty directors of the Leder Human Biology program at Harvard Medical School to organize, teach, and evaluate courses required for the translational medicine certification
- Serve as Associate Course Director in BCMP 234 (Cellular Metabolism and Human Disease), one of the required semester-length courses for the LHB Program. Manage and mentor the course’s Teaching Fellows and help lead critical reading sections
- Provide support and guidance for student-organized para-curricular activities associated with the Leder Human Biology program
- Catalyze and evaluate initiatives to improve biomedical education across Harvard Medical School, and make evidence-based recommendations to faculty and teaching staff on curricular design
- Support a short course on Case Studies in Human Biology
Qualifications:
- An earned doctorate in a field relevant to biology, biochemistry, or the biomedical sciences
- Experience teaching graduate or undergraduate science courses
- Advanced knowledge of or training in translational biomedical sciences (preferred)
- Postdoctoral research in a field relevant to the translational sciences (preferred)
Job Skills and Competencies:
- Ability to work collaboratively with multiple faculty with the purpose of organizing a semester-long course in cellular metabolism and human disease
- Experience applying evidence-based teaching methods and technological innovations to the classroom and working with faculty members to develop effective teaching strategies
- Strong organizational and management skills
- Commitment to the professional development and mentorship of PhD students in the Leder Human Biology program
The CF appointment is renewable annually for a maximum of three years and is non-tenure-track. The fellowship is intended for early-career scientist-educators, therefore applications from candidates with more than 5 years of postdoctoral research or teaching experience are discouraged. Fellows are appointed as research associates, with possible promotion to the rank of Lecturer, contingent on experience and performance. The LHB Curriculum Fellow position is open for an immediate start. Applications will be reviewed as they are received until the final submission deadline of 9 AM Eastern Time on Friday, September 4th. The position will remain open until filled.
To apply:
Applicants should email a single PDF document containing:
(1) a letter of application that addresses your interest in and qualifications for the position
(2) a curriculum vitae
(3) a teaching statement
(4) the names and contact information of three professional references
Email application materials to cfp@hms.harvard.edu, attention Dr. Bradley Coleman, Director of the HMS Curriculum Fellows Program.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.  (posted 8.5.20)

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~DEPARTMENTAL LISTINGS~

BIOLOGICAL CHEMISTRY AND MOLECULAR PHARMACOLOGY

Don Coen's Lab in the Department of Biological Chemistry & Molecular Pharmacology and David Knipe's Lab in the HMS Department of Microbiology are jointly seeking applicants for a postdoctoral research fellow to perform research on mechanisms that regulate whether herpes simplex virus undergoes a productive ("lytic") infection or a latent infection in neurons. Potential mechanisms that might be studied include neuronal factors, epigenetic and chromatin modifications, microRNAs, and translational regulation.   Studies in both cell culture models, including human iPSC-derived neurons and mouse models are anticipated. Experience with one or more of these areas of research, viruses, immunofluorescence and in situ hybridization methods, and/or RNAseq is desirable, but not required.

If you're interested, please send an email explaining your qualifications and interests to Don Coen (don_coen@hms.harvard.edu) and/or David Knipe (david_knipe@hms.harvard.edu) along with your curriculum vitae and the names and contact information of three references. (posted 11.19.20)

The Lassar Lab

The Lassar lab at Harvard Medical School (in the Department of Biological Chemistry & Molecular Pharmacology) has an opening for a postdoctoral fellow to study the transcriptional regulatory network that controls both the formation and maintenance of articular cartilage.  Current efforts are to understand how extracellular signals promote the expression and regulate the activity of a newly identified articular cartilage transcription factor that is essential for articular cartilage formation.  The lab seeks to understand the gene regulatory network that controls synovial joint formation by use of novel genetically engineered mice, isolation of articular chondrocyte precursor populations, RNA-Seq, ATAC-Seq, and ChIP-Seq technologies.  Fundamental knowledge gained from these approaches will be leveraged to develop novel regenerative approaches to treat joint pathology in murine models of osteoarthritis.  

Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry, Genetics or a related field.  In addition, the applicant should be highly motivated, have an excellent working knowledge of molecular biology techniques and be able to work constructively with others.  Prior work with genetically engineered mice and/or regulation of gene expression would be a plus. Interested individuals should send a cover letter, curriculum vitae, and the names/e.mail addresses of three people who could provide letters of reference by email to Andrew_Lassar@hms.harvard.edu. (Posted 9.27.19)

Postdoctoral Research Fellow and Project Manager, Translational Metabolism Research
Job Description: The Sheu Lab at Brigham and Women’s Hospital and the Devlin Lab at Harvard Medical School are currently seeking a talented, driven, PhD-level scientist to lead these labs’ joint effort to develop a novel therapeutic for the treatment of type 2 diabetes mellitus (T2D) and obesity. Dr. Eric Sheu is an Assistant Professor of Surgery at Brigham and Women’s Hospital. The Sheu lab studies mechanisms of diabetes remission following bariatric surgery.  Dr. Sloan Devlin is an Assistant Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. The Devlin lab uses strategies from chemical biology to understand how small molecules produced by human gut bacteria affect human health and disease.
This position is a unique opportunity for a postdoctoral fellow to lead a research team and work at the intersection of academia and industry. This postdoc, along with the principle investigators, will develop a novel T2D therapeutic using in vitro and in vivo models of diabetes. This individual will both perform experiments in-house and will also plan and manage studies carried out at contract research organizations. The position will involve significant interactions with industry, venture capital, and private funding agencies. This position provides an excellent opportunity any person interested in drug discovery to jump-start his/her career in translational science.
Qualifications:

  • Innovative experimental biologist with significant previous basic science research experience who has a strong interest in accelerating scientific discoveries to the clinic.
  • Ph.D. and/or M.D. or graduating with a PhD by summer of 2019.
  • Background and expertise with mouse models of obesity and diabetes, including glycemic and insulin tolerance testing, are highly desired.
  • Experience in molecular / cell biology, specifically in relation to the study of metabolism, is preferred.
  • Strong history of publication in peer-reviewed journals.
  • Ability to work effectively with interdisciplinary teams.
  • Excellent oral and written communication skills.

Please send cover letter, C.V., and references to BOTH Eric Sheu, MD, PhD and Sloan Devlin, PhD. (Posted 5.22.19)

The Arthanari Lab
Blacklow Laboratory at Harvard Medical School
The Brown Laboratory
 

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BIOMEDICAL INFORMATICS

Patel Group - Postdoctoral Fellows (posted 4.5.19)

The Department of Biomedical Informatics (DBMI) at Harvard Medical School is seeking a Postdoctoral Fellow with experience in database management (SQL), scientific programing (Python, R) and cloud computing (AWS, Google Cloud Platform) and an interest -- but not necessarily experience -- in biomedical data science (or related field, such as population genetics, biostatistics, or epidemiology). You will work with investigators from the Patel Group and Arjun Manrai, faculty members at HMS DBMI and build tools and computer infrastructure to enhance use of large and disparate datasets from the domains of biology and population health to enable precision medicine. The goal of our efforts is to usher in a new age of precision medicine through combining lab, ancestry, demographic, environmental, and genetic data to enable accurately classify disease and health that accounts for the diversity of the human population.
Job listing on Department website: 
https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/patel-group-0
Email applications including curriculum vitae, summary statement of personal objectives, and the names and email addresses of 2-3 references to Chirag Patel (chirag_patel@hms.harvard.edu).

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Postdoctoral Positions in the Lab of Paul Avillach (posted 2.12.19; updated 11.15.19)

1) Phenotype extraction and biomedical ontologies
Summary
The Department of Biomedical Informatics (DBMI) at Harvard Medical School is looking for a Postdoctoral Fellow to help build cutting edge research platforms. The real value in biomedical research lies not in the scale of any single source of data, but in the ability to integrate and interrogate multiple, complementary datasets simultaneously. We are combining clinical and genomics data across different scales and resolutions to enable new perspectives for essential biomedical questions. The research focuses on the development of novel methods and techniques for the integration of multiple heterogeneous clinic cohorts, Electronic Health Records data and multiple types of genomics data to encompass biological observations.

Responsibilities
The Postdoctoral Fellow will be responsible for developing novel methodologies and applications to facilitate high-throughput phenotype extraction, harmonize content with biomedical ontologies and integrate clinical and molecular genomic data.
The diversity of subject matter will require a creative mind and a candidate capable of deploying imaginative strategies and who is dedicated to solving complex and challenging problems within an interdisciplinary environment.

Basic Requirements
Candidates must have a PhD degree (or MD/PhD) in biomedical informatics, bioinformatics, Computational Biology, computer science, or a related field. Curriculum in and/or experience with standardized ontologies, terminologies, metadata, and related technologies as well as experience in programming and software development will be necessary for this opportunity. The candidate interested in this position must be highly motivated, willing to learn and demonstrate initiative in assigned tasks. Excellent written and verbal communication skills are crucial.

Additional Requirements
Preferred requirements for this position include experience with the Unified Medical Language System (UMLS), statistics, data mining and machine learning. Experience with R, Python, and/or Perl is desirable.

Terms
The position is available immediately and can be renewed annually.

How to apply
Email applications including curriculum vitae, summary statement of personal objective and research interests, PDFs of the best two papers, and the names and email addresses of three references to paul_avillach@hms.harvard.edu

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2) Post-Doctoral Fellowship at Harvard-MIT Center for Regulatory Science | Harvard Program in Therapeutic Science
The Harvard Program in Therapeutic Science (HiTS) invites applications for a fellowship position at the Harvard-MIT Center for Regulatory Science. The fellow will work with a multidisciplinary team to develop and evaluate novel computational methods to support automated detection of drug-drug interactions in large and disparate healthcare datasets.
ABOUT THE FELLOWSHIP PROGRAM
The Harvard-MIT Center for Regulatory Science is a partnership between Harvard, MIT and the FDA, focused on building innovative approaches for the development and evaluation of medical products. Working across academia, industry, and government institutions, the Center promotes regulatory science through research and education programs, uniting stakeholders under a common mission: promoting optimal patient health outcomes through biomedical innovation and the availability of safe and effective diagnostics and treatments. The Regulatory Science Fellows Program draws individuals of diverse experiences who are passionate about using novel applications of data science to improve the use of therapeutics in patient populations.
For this position, the Fellow will work with faculty at Harvard in the Department of Biomedical Informatics https://dbmi.hms.harvard.edu. The fellow will be based in the Avillach Lab, an interdisciplinary research group focused on the development of cutting edge techniques for the integration of multiple heterogeneous biological and clinical cohorts with the overarching goal of supporting individualized data-driven healthcare.
PROJECT DETAILS
The application of  healthcare claims data and electronic health records for use in pharmacoepidemiological studies is booming. Drug–drug interactions can be identified by mining such databases, including adverse drug reactions (ADRs) resulting from the prescription of a combination of drugs (CADRs), considered a special class of drug-drug interactions. While many ADRs can be anticipated and hence avoided, CADRs are highly complex and challenging to identify and, as a consequence, have not been well studied. CADRs may represent as many as 30 % of unexpected ADRs and their elucidation is of particular interest to the FDA.

The fellowship project will develop new signal detection algorithms using data mining techniques in real-world healthcare data derived from claims and electronic healthcare records. The project will aim to identify potential pharmacovigilance signals concerning drug-drug interactions across multiple diseases and syndromes.
Research activities include, but are not limited to:
- Extract and analyze information from a nationwide claims database including 67 million subjects
- Extract and analyze information from healthcare records in an academic pediatric hospital including 1.8 million patients
- Develop and test methods to detect adverse drug reactions from billing codes, drug prescriptions and lab value results
- Disseminate findings through national and international conferences and in peer-reviewed scientific publications
Basic Qualifications
PhD in computer science, engineering or a related field; Expertise in SQL query language; Expertise in R or Python programing languages
Application Procedure and Requirements
Applications will be accepted until the position is filled. Please include the following when applying: Curriculum vitae; Cover letter and a 2-page description of relevant experience as a single PDF; DOI or PMCID of up to three relevant publications. Selected candidates will be asked to provide letters of reference.

Additional Position Description
Host Institution: Harvard Medical School | Appointing Department: Harvard Program in Therapeutic Science |Research Laboratory: Paul Avillach |Location: Boston, MA |Category: Scientist |Other responsibilities: no administrative or teaching obligations |Duration of fellowship: 2 years

Contact: Paul Avillach, MD, PhD, Department of Biomedical Informatics, 10 Shattuck Street, Boston, MA 02115

 

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Postdoctoral Positions in the Lab of Maha Farhat

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Postdoctoral Positions in the Lab of Peter Kharchenko  (posted 2.12.19)
Job Description
The Department of Biomedical Informatics (DBMI) at Harvard Medical School and the Kharchenko Lab is looking to recruit several postdoctoral fellows interested in pursuing one or more of the following topics in computational biology:

Single-Cell Genomics
The fellow will be charged with developing novel statistical approaches to the analysis of single-cell genomic data, mathematical modeling of cellular processes, as well as applications of such techniques to study healthy and diseased tissues. Strong background in statistics, modeling of stochastic processes and multicellular systems is desired.

Computational analysis of epigenetic mechanisms disrupted in cancer and other disease-disrupted tissues
The fellow will be responsible for developing and applying computational methods for integrative analysis of genome-wide epigenetic, transcriptional and proteomic data, aiming to identify specific factors and molecular mechanisms underlying misregulation of the epigenetic states in several types of human cancer. The ideal candidate should have a strong quantitative background, ample experience with analysis of sequencing assays, and strong interest in cancer biology.

Computational analysis of nucleosome organization
The fellow will be part of the central analysis group for the extensive 4D-nucleus consortium project funded by the NIH. The efforts will be focused on the development of analysis techniques for the next generation of experimental methods for measuring organization and dynamics of the eukaryotic nucleus that are being developed by the members of the consortia. Experience with analysis of Hi-C and relevant imaging data is strongly preferred.

All projects are being conducted in close cooperation with the expert bench-side laboratories, providing an excellent opportunity for collaborative research. Harvard Medical School and the Department of Biomedical Informatics also provides for a rich scientific environment, with a number of relevant seminar series, invited speakers, and many neighboring laboratories working on related projects.

PhD in Computational Biology, Statistics, Physics or other related discipline is required. A strong record of publications in the field is desired.

To apply – please send cover letter, curriculum vitae and contact information for at least two references to Dr. Peter Kharchenko at peter_kharchenko@hms.harvard.edu. Applications will be considered until the positions are filled. Please specify which project you are interested in.

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Kharchenko Lab: Postdoctoral Opportunities (posted 1.28.19)
Single-cell Transcriptomics, Epigenetics | Spatially-resolved Transcriptomics | Gene Regulation | Cancer Heterogeneity, Therapy Resistance, Immune Microenvironment | Tissue Organization

A group led by Peter Kharchenko at the Department of Biomedical Informatics of the Harvard Medical School is searching for postdoctoral fellows interested in developing and applying novel statistical, computational and experimental approaches to study challenges posed by cancer biology and development/maintenance of healthy tissues at a single-cell resolution. The research questions are being pursued in close cooperation with expert bench-side laboratories, providing an excellent opportunity for collaborative research. In particular, we are looking for researchers interested in joining our efforts on single-cell atlas of human brain, lung, kidney and other organs as part of the NIH funded BRAIN and HuBMAP consortia. Fellows interested in application of advanced image analysis techniques to study organization of biological tissues are encouraged to apply.

More info at
http://pklab.med.harvard.edu/

Areas of Interest: Single-Cell Analysis, Spatial Analysis, Statistics, Cancer, Tissue homeostasis

Candidate qualifications:
- Robust knowledge of statistical methods, and probabilistic modeling techniques
- Experience with quantitative analysis of modern biological assays
- We welcome experience in image analysis, graphical models, and advanced machine learning
- A strong interest in conducting collaborative research
- Track record of publications in peer-reviewed journals

How to apply: Please send cover letter, curriculum vitae and contact information for at least two
references to Peter Kharchenko at peter_kharchenko@hms.harvard.edu. Applications will be considered until the position is filled.

Employer: Department of Biomedical Informatics has been recently formed at the Harvard Medical School to lead development of computational and informatics techniques to address pertinent challenges in modern biological sciences and medicine. The Department’s faculty conduct research at the intersection of biomedicine and information sciences, including bioinformatics, functional genomics, translational medicine, and clinical knowledge management. The Department also hosts the Bioinformatics & Integrative Genomics PhD program (sponsored by NHGRI) and the Biomedical Informatics Masters program.

Harvard Medical School is an Equal Opportunity/Affirmative Action Employer.

Women and minorities are especially encouraged to apply.

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Gehlenborg Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/gehlenborg-lab

Kharchenko Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/kharchenko-lab

Patel Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/patel-group

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CELL BIOLOGY

Yuan Laboratory at Harvard Medical School


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CENTER FOR BIOETHICS


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GENETICS

Yankner Laboratory at Harvard Medical School

 

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GLOBAL HEALTH AND SOCIAL MEDICINE

Postdoctoral Fellowship in Multidrug-Resistant Tuberculosis Epidemiology
Start date: flexible | Location: Boston, MA | Duration: 2 years | Salary: consistent with NIH guidelines

Project Description
Applications from PhD or other doctoral-level degree holders are invited for a full-time project focused on improving the quality of evidence generated from observational treatment cohorts of multidrug-resistant (MDR) tuberculosis (TB). The position will be based in the Department of Global Health and Social Medicine (DGHSM) at Harvard Medical School, which conducts research to improve the practice of medicine, the delivery of treatment, and the development of health care policies locally and worldwide. Researchers at DGHSM have a long history of conducting research on tuberculosis, HIV, and other conditions. The selected candidate will join a team of epidemiologists and clinicians aiming to improve access to high-quality evidence-based care for MDR-TB around the world.
The postdoctoral fellow will work with us on the endTB observational study. Comprised of over 2,600 patients in 17 countries, this is the largest multi-country study of patients receiving MDR-TB treatment with the newer drugs, bedaquiline and delamanid. The postdoctoral fellow will apply advanced epidemiologic methods (e.g., marginal structural models, g-estimation) to longitudinal data to answer pressing outstanding questions related to the safety and effectiveness of different MDR-TB regimens. Under this NIH-funded initiative, the postdoctoral fellow will also contribute to the implementation of a prospective cohort study of patients receiving a shortened, all-oral MDR-TB regimen in one of five countries.
The successful applicant will be expected to participate as lead author on publications arising from this work and to communicate findings in oral presentations at national and international conferences. We are seeking candidates willing to commit to at least two years of work on this project.

Qualifications and Skills

  • Doctoral degree holders (or 2020 degree candidates) in Epidemiology, Biostatistics or related field.
  • Experience applying advanced epi methods, including: marginal structural models, g-formula and simulation studies.
  • Advanced programming skills in a statistical package such as SAS, Stata, or R.
  • Strong writing skills.
  • Ability to work collaboratively.
  • Interested in global health.

Application Instructions
Email the following items in one PDF with the surname as the first word of the PDF file: (1) cover letter stating long-term career aims, interest in the project, and suitability for the position, specifically referring to the criteria listed above; (2) curriculum vitae; (3) two or three relevant publications or manuscripts; and (4) contact information for three to five potential references. Applications should be emailed to: rebecca_grow@hms.harvard.edu

See this website for information about our department: https://ghsm.hms.harvard.edu/.

Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Applications from women and underrepresented minorities are strongly encouraged.  
(posted 7.10.20)

 

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HARVARD CATALYST

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HARVARD PROGRAM IN THERAPEUTIC SCIENCE (HiTS)

Postdoctoral Fellowship for Geographic Information Systems (GIS) to Pathology | HiTS | HMS
Description: The objective of this project is to apply methods developed for the analysis of geographic and ecological features in GIS (Geographic Information Systems) to the understanding of human cancers. This will involve applying geospatial analytics, spatial and spatiotemporal statistics, environmental image processing, and ecosystem modeling techniques to human tumor images collected using very recently developed methods. The study aims to characterize patterns, relationships, and interactions among tumor cells, immune cells, and healthy cells based on these landmarks before, during, and after exposure of patients to therapeutic drugs.The position involves a joint appointment between the Harvard University Center for Geographic Analysis (CGA) and the Harvard Medical School Laboratory of Systems Pharmacology (LSP). The candidate will have space assigned at both the CGA and LSP and will attend group meetings and similar activities at both research centers. The appointment is for one year with the possibility of renewal based on satisfactory performance and continued availability of funding. This position has no teaching or administrative duties.

Qualifications: The successful candidate will have an MD and/or PhD and relevant experience in cancer immunology and/or breast or ovarian cancer research, geographic information science, remote sensing, or a related field. Interest in biological imaging is required. Prior experience working with mouse or human tissues and mastery of basic molecular biology techniques and cell culture are required.  Proficiency in fluorescence microscopy and/or single cell methods such as flow cytometry/CyTOF are also highly desirable.  The candidate should have an interest in acquiring skills in image processing and analysis and use of computational pipelines to produce and analyze single-cell data. A general understanding of Matlab/Python and prior experience in working with mouse or human tissues, including familiarity with tissue processing and analysis as well as basic knowledge of standard IHC is preferred. Excellent written and spoken English are required.

To apply, send a curriculum vitae, statement of research interests, and names and contact information for three references to Laura Maliszewski (laura_maliszewski@hms.harvard.edu). Research papers (up to three) are welcome but optional. Review of applications will begin immediately and end when the position is filled. Incomplete applications will not be reviewed. More information HERE. (Posted 8.30.19)

Postdoctoral Fellowship for Innovative Single-Cell Discovery Platform for Women’s Cancers | HiTS | HMS
Description: The Harvard Medical School (HMS) Laboratory of Systems Pharmacology (LSP) and Women’s Cancer Program at Dana-Farber Cancer Institute (DFCI) seeks an outstanding postdoctoral fellow who will use innovative single-cell methods to study mechanisms of immunotherapy response and resistance in patient tumors.  The fellow will be based in the laboratories of Dr. Peter Sorger at HMS and Dr. Beth Mittendorf at DFCI, where he/she will routinely interact with physicians, basic scientists and computational biologists to conduct high impact translational research.  The fellow’s research efforts will directly inform the design of novel clinical trials of immunotherapy for breast and ovarian cancer. The fellow will lead efforts to apply single cell genomics and imaging, including a new tissue-based, multiplexed immunofluorescence assay (tCyCIF: www.cycif.org) to study the tumor microenvironment in breast and ovarian tumors.  The high-dimensional single cell data will be used to identify novel cell types, functional states and drug targets. This position has no teaching or administrative duties.

Qualifications: The successful candidate will have an MD and/or PhD and relevant experience in cancer immunology and/or breast or ovarian cancer research.  Prior experience working with mouse or human tissues and mastery of basic molecular biology techniques and cell culture are required.  Proficiency in fluorescence microscopy and/or single cell methods such as flow cytometry/CyTOF are also highly desirable.  The candidate should have an interest in acquiring skills in image processing and analysis and use of computational pipelines to produce and analyze single-cell data.   A general understanding of Matlab/Python and prior experience in working with mouse or human tissues, including familiarity with tissue processing and analysis as well as basic knowledge of standard IHC is preferred.  Excellent written and spoken English are required.

To apply, send a curriculum vitae, statement of research interests, and names and contact information for three references to Laura Maliszewski (laura_maliszewski@hms.harvard.edu). Research papers (up to three) are welcome but optional. Review of applications will begin immediately and end when the position is filled. Incomplete applications will not be reviewed. More information HERE. (Posted 8.30.19)

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HEALTH CARE POLICY

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IMMUNOLOGY

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MICROBIOLOGY

Don Coen's Lab in the Department of Biological Chemistry & Molecular Pharmacology and David Knipe's Lab in the HMS Department of Microbiology are jointly seeking applicants for a postdoctoral research fellow to perform research on mechanisms that regulate whether herpes simplex virus undergoes a productive ("lytic") infection or a latent infection in neurons. Potential mechanisms that might be studied include neuronal factors, epigenetic and chromatin modifications, microRNAs, and translational regulation.   Studies in both cell culture models, including human iPSC-derived neurons and mouse models are anticipated. Experience with one or more of these areas of research, viruses, immunofluorescence and in situ hybridization methods, and/or RNAseq is desirable, but not required.

If you're interested, please send an email explaining your qualifications and interests to Don Coen (don_coen@hms.harvard.edu) and/or David Knipe (david_knipe@hms.harvard.edu) along with your curriculum vitae and the names and contact information of three references. (posted 11.19.20)

Abraham Laboratory at Harvard Medical School

Gehrke Laboratory at Harvard Medical School

Nibert Lab

Yang Laboratory at Harvard Medical School


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NEUROBIOLOGY

Regehr LabPostdoctoral Positions (posted 7.10.20)
The Regehr lab is seeking postdoctoral fellows to work in an interactive lab environment in which the candidate will use multiple cutting edge techniques to address diverse questions. Areas of investigation include: the molecular and functional characterization of synaptic transmission, the behavioral significance of short-term synaptic plasticity, characterization of cerebellar circuitry, and the role of the cerebellum in motor and social behaviors. Techniques used include: slice electrophysiology, calcium measurements, caged neurotransmitters, AAV manipulation, optogenetics, mouse genetics, immunofluorescence, FISH, single unit electrophysiology in awake behaving animals, behavioral analysis (including many social behaviors, gait analysis, Motion Seq, VOR and conditioned eyeblink), serial electron reconstructions (in collaboration with the Lee lab), single cell molecular characterization of neurons in the cerebellum (in collaboration with the Makosco lab), and in vivo 2-photon functional imaging (in collaboration with the Harvey lab). Multiple positions are available. The ideal candidate should be creative, able to both lead their own independent project, and able to work with others on collaborative projects in a highly interactive environment.
Please email a cover letter, a curriculum vitae, and names & email addresses of three references to:
Wade G. Regehr
Department of Neurobiology
Harvard Medical School
Goldenson 307
Boston, MA 02115
Email: wade_regehr@hms.harvad.edu

Website: https://regehrmedharvard.wordpress.com/
(posted 7.10.20)

 

Harwell Lab

 

Born Lab (and Haefner Lab)  

Drugowitsch Lab at Harvard Medical School

Gu Laboratory at Harvard Medical School

Kaeser Lab at Harvard Medical School

Weitz Laboratory at Harvard Medical School

Goodrich Laboratory at Harvard Medical School

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SYSTEMS BIOLOGY

Mootha Laboratory at Harvard Medical School

Megason Laboratory at Harvard Medical School

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HARVARD SCHOOL OF DENTAL MEDICINE 

Yang Laboratory at Harvard School of Dental Medicine

A post-doctoral position is available in the Yang lab based in the Department of Developmental Biology at the Harvard School of Dental Medicine.
The laboratory of Dr. Yingzi Yang has a longstanding and intense interest in defining the functional mechanisms of Wnt, Hippo, and Hedgehog signaling pathways in development and disease pathogenesis including cancer. We are recruiting a motivated postdoctoral fellow to conduct bone or liver research. We use molecular, biochemistry/cell biology and genomic approaches in both mouse models and human specimens. Our research also involves cutting-edge imaging techniques and liver tumor models. Candidates with strong training in the areas of signal transduction, mechanotransduction, liver tumor microenvironment and mouse genetics are particularly encouraged to apply. The positions are funded by NIH and Harvard University.
The candidate should have a PhD degree in biomedical sciences with less than 3 years of postdoctoral experience and a proven record of scientific productivity. Basic skills in molecular biology, genetics and cell biology are required. Duties and responsibilities of the successful candidate will include:

  • strong abilities to work independently and with self-initiative;
  • abilities to vigorously pursue scientific projects, both conceptually and experimentally, with pro-active thinking and action;
  • collaboration with other research staff, supervision and training of lab members;
  • writing and editing of manuscripts, research presentations at departmental seminars and scientific meetings.

Salary will follow NIH and university guidelines.
To apply, please send a brief statement of research interests, CV and contact information of three references to:
Yingzi Yang, PhD |
Yingzi_yang@hsdm.harvard.edu
This position is granted funded and reappointed annually.
The Harvard School of Dental Medicine values diversity among its faculty, is committed to building a culturally diverse intellectual community, and strongly encourages applications from women and minorities. (posted 11.3.20)

 

 

Two Postdoctoral Positions | Harvard Medical School/Harvard School of Dental Medicine | Drs. Baron and Gori joint Laboratory (Baron-Gori lab)
GENERAL SUMMARY: Two Postdoctoral positions are available in the joint laboratory of Dr. Baron and Dr. Gori, Division of Bone and Mineral Research, Department of Medicine, Harvard Medical School/ Harvard School of Dental Medicine. The longstanding interest of our laboratory is to understand the molecular, cellular and genetic basis of bone growth and remodeling and the regulation of skeletal homeostasis in health and disease in humans, using animal models. The focus of one of these positions is to study the biology of the periosteal surface. In particular, our objective is to identify the role of Sfrp4, a Wnt signaling inhibitor we have shown to be implicated in Pyle Disease, in the expansion, differentiation and/or function of periosteal stem and osteoprogenitor cells. The focus of the other position is to examine novel signaling mechanisms by which PTH regulates Wnt signaling, increases bone formation rate and represses bone marrow adipose tissue and its role in the anabolic action of PTH/PTHrP in bone. A separate aspect of this work is to understand the role of osteocyte biology in the responses to PTH/PTHrP. Our laboratory aims for excellence in research and makes all efforts to publishing its work in the top tier scientific and medical journals. Training of young scientists is also a key aspect of our laboratory, with a very successful history.

The Baron/Gori laboratory is currently funded by three NIH institutes: NIDCR (Gori), NIDDK and NIAMS (Baron) as well as by other sources.

EDUCATION AND EXPERIENCE REQUIRED: The applicants must have a PhD degree. Combined MD/PhD or DDS-DMD/PhD degrees are a plus. We seek highly motivated young scientists who can work independently with strong written and oral communication skills. These projects involve the use of genetically engineered mice, cell and molecular biology and bioinformatic techniques as well as culture of primary cells and cell lines. Commensurate with experience, first author publication(s) in top-tier bone and/or cell and molecular biology journals, expertise in signal transduction analysis, FACS analysis and/or large-scale data analysis, specifically bulk and single cell RNA-seq, will be considered a plus. Prior experience in skeletal research in addition to the above skills is a plus but not a requirement.

APPLICATION REQUIREMENTS: To apply for this position, please email a cover letter, C.V. and three reference contacts to: Francesca_gori@hsdm.harvard.edu and Roland_Baron@hms.harvard.edu (posted 7.30.20)

 

KOTA LABORATORY
Kota Laboratory at Harvard School of Dental Medicine. A postdoctoral position is available to study mono-allelic gene expression and epigenetic gene regulation of skeletal diseases.
Projects will be focused on understanding the regulation of gene expression in ES cells, MSCs and mouse models of skeletal disease.

Successful candidates will have a strong background in molecular biology, cell biology, and biochemistry. Experience and knowledge in ES cell culture, molecular biology techniques commonly employed in RNA, chromatin analysis, protein biochemistry, RNA-seq, Chip-seq , NGS data analysis and mouse genetics are preferred. The candidate will be expected to work independently and have excellent written and verbal communication skills. This position is granted funded and reappointed annually. The Harvard School of Dental Medicine values diversity among its faculty, is committed to building a culturally diverse intellectual community, and strongly encourages applications from women and minorities. Basic Qualification: PhD in molecular biology, bio-chemistry or cell biology is required.

Additional Qualification: Experience with data analysis and statistical/programming packages (SQL, R, and Linux) preferred. Some prior research experience in public health preferred. Interested candidates can send CV, a brief description of research experience, and contact details of 3 references to: Dr. Satya Kota by email: satya_kota@hsdm.harvard.edu  (posted 6.3.20)

 

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WYSS INSTITUTE (Department job site)

Postdoctoral Fellows Positions at the Wyss Institute for Biologically Inspired Engineering
Visit the Wyss Institute's website to find out positions available: http://wyss.harvard.edu/viewpage/191/postdoctoral-positions

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