Open Postdoc Positions

Postdoctoral Positions at HMS Quad-based Labs

Featured Faculty Positions | The Dean's Postdoctoral Fellowship | Therapeutics Innovation Fellowship Program | Curriculum Fellows ProgramBiological Chemistry and Molecular Pharmacology | Biomedical Informatics | Cell Biology | Center for Bioethics | Genetics | Global Health and Social Medicine | Harvard Catalyst | Harvard Program in Therapeutic Science | Health Care Policy | ImmunologyMicrobiology | Neurobiology | Systems Biology | Harvard School of Dental Medicine | Wyss Institute

This page lists some of the postdoctoral positions currently available on the HMS Quadrangle. Many principal investigators do not advertise their postdoctoral positions with us, so if the PI you want to work with isn't listed here, please contact her/him directly. Please do not send your CV to the administrator of this page.
For non-Quad or external positions please see: postdoc.hms.harvard.edu/job-opportunities

Quad Departments: to have an opportunity listed on this page, send along a description of the postdoctoral position and contact information to us HERE. Please direct any questions to postdoc_office@hms.harvard.edu.

Postdoc openings at other Harvard affiliated institutions:
Beth Israel Deaconess Medical Center | Brigham & Women's Hospital | Children’s Hospital | Dana-Farber | Joslin | Mass General Hospital * | McLean Hospital* | T.H. Chan School of Public Health*
*Please note: some Harvard affiliates do not advertise individual postdoc positions with us, it may be best to identify a PI conducting work in your specific area of interest, and to email that PI directly with your CV and cover letter.

-FEATURED FACULTY POSITIONS-


~FEATURED FELLOWSHIP OPPORTUNITIES~

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The Dean's Postdoctoral Fellowship

The Dean’s Postdoctoral Fellowship at Harvard Medical School is a two-year research fellowship established to nurture, advance, and retain a diverse scientific workforce that will continue to contribute to diversity through their ongoing academic and research scholarship.  The fellowship program prepares scientists from groups historically underrepresented in the basic and social sciences for careers in academia and other sectors. Fellows benefit from a highly innovative and creative research environment that emphasizes scientific rigor, collaboration, and the pursuit of excellence in science. 

BENEFITS
The two-year fellowship provides funding in the amount of $50,000/year, and DPF fellows are eligible for Harvard’s generous benefits package. They receive additional opportunities for career enhancement, mentorship, seminars, workshops, and conferences, along with a robust support network, through the Harvard Medical School Scholars in Translational and Academic Research (HMS STARs) program.

ELIGIBILITY

·         Have an MD, MD/PhD, PhD, ScD, or equivalent degree in the basic or social sciences.

·         Have United States citizenship or permanent resident status.

·         Come from a background that is historically underrepresented in the basic and social sciences.

·         Have no more than two years of postdoctoral experience.

ELIGIBLE DEPARTMENTS
Fellows conduct research with faculty within the basic and social science departments at Harvard Medical School. For a list of eligible departments, click here.

APPLICATION PROCESS
The application for the Dean’s Postdoctoral Fellowship is available on the DICP website at www.mfdp.med.harvard.edu/deanspostdoc
Applicants need to submit this form along with a cover letter, CV, and a statement that makes the connection between the mission of the Fellowship and their research interests and professional goals.

RECOMMENDATIONS
Three letters of recommendation are required, one of which must be from the applicant’s thesis advisor. For those who have held a postdoc position, the second letter must be from their postdoc advisor.

DEADLINE
Applications are currently accepted on a rolling basis, with the recommendation that they be submitted at least 4 months ahead of the candidate’s anticipated start date. 

SELECTION
Applications are reviewed by a committee comprised of Harvard Medical School faculty and administrators. Fel­lows are selected on the basis of their demonstrated aca­demic achievement, scholarly promise, commitment to research, potential to add to the diversity of the Harvard Medical School community, and the likelihood that the in­dividual may become an independent scientist and societal leader who, upon the completion of the fellowship, will continue to contribute to diversity through their ongoing academic and research scholarship.

Interested candidates are encouraged to contact Dean’s Postdoctoral Fellowship Program at dicp_deanspostdoc@hms.harvard.edu or by phone at 617-432-9051 with any questions they may have.

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THERAPEUTICS INNOVATION FELLOWSHIP PROGRAM

 - No positions available currently -

 

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The Harvard Medical School Curriculum Fellows Program (CFP)

Curriculum Fellow in Microbiology
The Harvard Medical School Curriculum Fellows Program (CFP) welcomes applications for a Curriculum Fellow in Microbiology. The CFP is a postdoctoral service and training program focused on curriculum development, teaching, and educational programming in the biological and biomedical sciences. Curriculum Fellows work closely with members of the Harvard faculty and administration to develop, deploy, and evaluate evidence-based graduate training. Fellows also receive mentorship and career advising to support their development as educators and help them succeed in a variety of education-focused careers. More detailed information about the Curriculum Fellows Program, the role of a CF, and outcomes of former CFs can be found on our website.
The Curriculum Fellow in Microbiology will focus on designing, managing, and evaluating aspects of the graduate microbiology curriculum at Harvard, with a primary focus on the Harvard Graduate Program in Bacteriology (GPiB). The GPiB is an interdisciplinary graduate training program and close-knit community that brings together students and faculty from across Harvard Medical School and the Harvard T.H. Chan School of Public Health. GPiB students participate in bacteriology-focused courses in their first and second years and continue to engage with the program through science, social, and professional/career development activities across all years of their graduate training. The Curriculum Fellow will work closely with the GPiB Faculty Directors and Director of Education, administrative staff, and a student steering committee to plan and implement GPiB curricular and para-curricular programming.
Specific responsibilities of the Curriculum Fellow in Microbiology include:
•    Leading administration, curriculum innovation, and evaluation of the core team-taught GPiB courses, Micro201 (Molecular Biology of the Bacterial Cell), and Micro202 (Mechanisms of Bacterial Pathogenesis and Host Immune Response). Teaching some content in these courses in areas relevant to the fellow’s interest or expertise.
•    Providing course design input for other GPiB-affiliated courses (for example, graduate microbiome courses).
•    Identifying instructors and providing course design input or administrative support for new nanocourses and workshops on emerging research tools or topics in bacteriology.
•    Collaborating with the GPiB student steering committee to design and manage implementation of para-curricular career and professional development initiatives to support growth of GPiB graduate students at all stages. These initiatives include activities like science communication training and group advising discussions/workshops on preparing for key graduate school decisions and milestones.
•    Collaborating with the GPiB student steering committee to design and manage initiatives to build research and mentoring/advising connections between students, post-doctoral fellows, alumni, and faculty. These initiatives include an annual program retreat and student-faculty or student-alumni dinners.
•    Supporting Diversity, Equity, and Inclusion across all aspects of the GPiB program, including curriculum development, recruitment, faculty training, student support, and pipeline programs.
•    Collecting and analyzing data about GPiB student experiences and academic and career outcomes to inform program improvement, and preparing components of the annual progress reports for the GPiB NIH T32 training grant.
•    Serving as the primary GPiB liaison and representative for current and prospective GPiB students, GPiB faculty, and Harvard offices/committees focused on supporting graduate education.
•    Developing new curricular or para-curricular initiatives in areas relevant to the fellow’s interest and expertise.
Qualifications:
• A Ph.D. in Microbiology or another relevant area of research by the time of appointment.
Qualified candidates will be evaluated based upon their:
•    Experience or demonstrated interest in teaching, curriculum development, or student career development/mentoring.
•    Scientific background or interest in the GPiB curriculum’s current content areas or future areas for growth (including, but not limited to, the application of quantitative and bioinformatic approaches to bacteriology).
•    Commitment and experience or interest in supporting Diversity, Equity, and Inclusion in science.
•    Organizational and written and oral communication skills.
•    Demonstrated capacity for independence, perseverance, innovation, and the ability to work as part of a team and balance competing priorities.
Fellowships are intended for early-career scientist-educators. The CF appointment is renewable annually for a maximum of three years and is non-tenure-track. Fellows are appointed as Research Fellows and typically earn promotion to the rank of Lecturer during the term of the fellowship. The ideal start date for this Curriculum Fellow is approximately October 1, 2021. The current COVID-19 restrictions in place at Harvard Medical School mean this position may begin remotely, but fellows will be expected to work in person in Boston, MA when this becomes possible.
To apply: Applicants should provide an application package that includes a cover letter that describes your interest in and qualifications for this position, a CV, a teaching statement, and the names and contact information of three professional references. The teaching statement is an opportunity to describe your philosophy of teaching in the context of your own experiences. Submissions will be evaluated according to the guidelines found on our website. A discussion of diversity, equity and inclusion is an important component of the teaching statement. Address emails to cfp@hms.harvard.edu, attention Dr. Bradley Coleman, Director of the HMS Curriculum Fellows Program. Review of applications will begin on Monday, August 16 and continue on a rolling basis thereafter. Applications received by Sunday, August 29th will receive full consideration.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law. (posted 7.28.21)

 

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~DEPARTMENTAL LISTINGS~

BIOLOGICAL CHEMISTRY AND MOLECULAR PHARMACOLOGY

Don Coen's Lab in the Department of Biological Chemistry & Molecular Pharmacology and David Knipe's Lab in the HMS Department of Microbiology are jointly seeking applicants for a postdoctoral research fellow to perform research on mechanisms that regulate whether herpes simplex virus undergoes a productive ("lytic") infection or a latent infection in neurons. Potential mechanisms that might be studied include neuronal factors, epigenetic and chromatin modifications, microRNAs, and translational regulation.   Studies in both cell culture models, including human iPSC-derived neurons and mouse models are anticipated. Experience with one or more of these areas of research, viruses, immunofluorescence and in situ hybridization methods, and/or RNAseq is desirable, but not required.

If you're interested, please send an email explaining your qualifications and interests to Don Coen (don_coen@hms.harvard.edu) and/or David Knipe (david_knipe@hms.harvard.edu) along with your curriculum vitae and the names and contact information of three references. (posted 11.19.20)

Postdoctoral Research Fellow and Project Manager, Translational Metabolism Research
Job Description: The Sheu Lab at Brigham and Women’s Hospital and the Devlin Lab at Harvard Medical School are currently seeking a talented, driven, PhD-level scientist to lead these labs’ joint effort to develop a novel therapeutic for the treatment of type 2 diabetes mellitus (T2D) and obesity. Dr. Eric Sheu is an Assistant Professor of Surgery at Brigham and Women’s Hospital. The Sheu lab studies mechanisms of diabetes remission following bariatric surgery.  Dr. Sloan Devlin is an Assistant Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. The Devlin lab uses strategies from chemical biology to understand how small molecules produced by human gut bacteria affect human health and disease.
This position is a unique opportunity for a postdoctoral fellow to lead a research team and work at the intersection of academia and industry. This postdoc, along with the principle investigators, will develop a novel T2D therapeutic using in vitro and in vivo models of diabetes. This individual will both perform experiments in-house and will also plan and manage studies carried out at contract research organizations. The position will involve significant interactions with industry, venture capital, and private funding agencies. This position provides an excellent opportunity any person interested in drug discovery to jump-start his/her career in translational science.
Qualifications:

  • Innovative experimental biologist with significant previous basic science research experience who has a strong interest in accelerating scientific discoveries to the clinic.
  • Ph.D. and/or M.D. or graduating with a PhD by summer of 2019.
  • Background and expertise with mouse models of obesity and diabetes, including glycemic and insulin tolerance testing, are highly desired.
  • Experience in molecular / cell biology, specifically in relation to the study of metabolism, is preferred.
  • Strong history of publication in peer-reviewed journals.
  • Ability to work effectively with interdisciplinary teams.
  • Excellent oral and written communication skills.

Please send cover letter, C.V., and references to BOTH Eric Sheu, MD, PhD and Sloan Devlin, PhD. (Posted 5.22.19)

The Arthanari Lab
Blacklow Laboratory at Harvard Medical School
The Brown Laboratory
 

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BIOMEDICAL INFORMATICS

Postdoc for Patel Lab-CCB Collaboration
Description: The Department of Biomedical Informatics (DBMI) in collaboration with the Center for Computational Biomedicine (CCB) at Harvard Medical School is seeking a Postdoctoral Fellow with experience in in biomedical data science and/or related field, such as population genetics, biostatistics, or epidemiology. You will work with Chirag Patel, Associate Professor of Biomedical Informatics at HMS DBMI and Robert Gentleman, Executive Director of HMS CCB, to build tools and computer infrastructure to enhance use of large datasets across numerous modalities, including environmental, image-based (MRI), genetic (GWAS) from the domains of biology and population health. The goal of our efforts is to usher in a new age of precision medicine through combining ancestry, demographic, environmental, and genetic data to enable accurately classify disease and health that accounts for the diversity of the human population. 
See recent papers in Nature Genetics, Diabetes Care, Diabetologia, Nature Communications, Cell Host and Microbe, and preprints (e.g., https://www.medrxiv.org/content/10.1101/2021.06.09.21258645v1, https://www.medrxiv.org/content/10.1101/2021.04.25.21255767v1) to get a flavor of the types of projects conducted in the group and our website: https://www.chiragjpgroup.org
Qualifications:
•    An earned doctorate in a Biomedical Informatics-related field (i.e. computational biology, computer science, etc.)
•    Proficiency with big data analytics including scripting languages such as R and python; frameworks such as tidyverse; and tools such as Spark
•    Proficiency with R/Shiny for analytics application development
•    Proficiency in computer tools, such as databases and SQL, command-line such as bash, and cluster compute applications
•    Experience with tools for bioinformatics and association analysis, such as PLINK, BOLT-LMM
•     (optional) Proficiency with tools such as tensorflow

Job Skills and Competencies
•    Self-motivated and highly detail oriented
•    Strong technical/systems design and development skills
•    Strong problem solving, testing, and debugging skills
•    Solid understanding of research data systems and database design
•    Excellent verbal and written communication skills
•    A solution focused attitude and ability to apply their skills to multiple projects at a time
•    Interest in warehousing of large patient and cohort databases
Start Date: As soon as possible
How to Apply: To be considered for this position, please email a single PDF document containing a letter of application that addresses your interest in and qualifications for the position, and a curriculum vitae. Please include the names and contact information of three references, who will be asked to supply letters or will be contacted by phone early in the application process. This is a one year term appointment with options for renewal. The position is available now at Harvard Medical School in Boston.
Address applications to: Chirag J Patel, Ph.D. Associate Professor of Biomedical Informatics
Contact: Nichole Parker  Nichole_Parker@hms.harvard.edu Research and Administrative Assistant  (posted 7.29.21)

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Postdoctoral Positions in the Lab of Paul Avillach (posted 2.12.19; updated 11.15.19)

1) Phenotype extraction and biomedical ontologies
Summary
The Department of Biomedical Informatics (DBMI) at Harvard Medical School is looking for a Postdoctoral Fellow to help build cutting edge research platforms. The real value in biomedical research lies not in the scale of any single source of data, but in the ability to integrate and interrogate multiple, complementary datasets simultaneously. We are combining clinical and genomics data across different scales and resolutions to enable new perspectives for essential biomedical questions. The research focuses on the development of novel methods and techniques for the integration of multiple heterogeneous clinic cohorts, Electronic Health Records data and multiple types of genomics data to encompass biological observations.

Responsibilities
The Postdoctoral Fellow will be responsible for developing novel methodologies and applications to facilitate high-throughput phenotype extraction, harmonize content with biomedical ontologies and integrate clinical and molecular genomic data.
The diversity of subject matter will require a creative mind and a candidate capable of deploying imaginative strategies and who is dedicated to solving complex and challenging problems within an interdisciplinary environment.

Basic Requirements
Candidates must have a PhD degree (or MD/PhD) in biomedical informatics, bioinformatics, Computational Biology, computer science, or a related field. Curriculum in and/or experience with standardized ontologies, terminologies, metadata, and related technologies as well as experience in programming and software development will be necessary for this opportunity. The candidate interested in this position must be highly motivated, willing to learn and demonstrate initiative in assigned tasks. Excellent written and verbal communication skills are crucial.

Additional Requirements
Preferred requirements for this position include experience with the Unified Medical Language System (UMLS), statistics, data mining and machine learning. Experience with R, Python, and/or Perl is desirable.

Terms
The position is available immediately and can be renewed annually.

How to apply
Email applications including curriculum vitae, summary statement of personal objective and research interests, PDFs of the best two papers, and the names and email addresses of three references to paul_avillach@hms.harvard.edu

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2) Post-Doctoral Fellowship at Harvard-MIT Center for Regulatory Science | Harvard Program in Therapeutic Science
The Harvard Program in Therapeutic Science (HiTS) invites applications for a fellowship position at the Harvard-MIT Center for Regulatory Science. The fellow will work with a multidisciplinary team to develop and evaluate novel computational methods to support automated detection of drug-drug interactions in large and disparate healthcare datasets.
ABOUT THE FELLOWSHIP PROGRAM
The Harvard-MIT Center for Regulatory Science is a partnership between Harvard, MIT and the FDA, focused on building innovative approaches for the development and evaluation of medical products. Working across academia, industry, and government institutions, the Center promotes regulatory science through research and education programs, uniting stakeholders under a common mission: promoting optimal patient health outcomes through biomedical innovation and the availability of safe and effective diagnostics and treatments. The Regulatory Science Fellows Program draws individuals of diverse experiences who are passionate about using novel applications of data science to improve the use of therapeutics in patient populations.
For this position, the Fellow will work with faculty at Harvard in the Department of Biomedical Informatics https://dbmi.hms.harvard.edu. The fellow will be based in the Avillach Lab, an interdisciplinary research group focused on the development of cutting edge techniques for the integration of multiple heterogeneous biological and clinical cohorts with the overarching goal of supporting individualized data-driven healthcare.
PROJECT DETAILS
The application of  healthcare claims data and electronic health records for use in pharmacoepidemiological studies is booming. Drug–drug interactions can be identified by mining such databases, including adverse drug reactions (ADRs) resulting from the prescription of a combination of drugs (CADRs), considered a special class of drug-drug interactions. While many ADRs can be anticipated and hence avoided, CADRs are highly complex and challenging to identify and, as a consequence, have not been well studied. CADRs may represent as many as 30 % of unexpected ADRs and their elucidation is of particular interest to the FDA.

The fellowship project will develop new signal detection algorithms using data mining techniques in real-world healthcare data derived from claims and electronic healthcare records. The project will aim to identify potential pharmacovigilance signals concerning drug-drug interactions across multiple diseases and syndromes.
Research activities include, but are not limited to:
- Extract and analyze information from a nationwide claims database including 67 million subjects
- Extract and analyze information from healthcare records in an academic pediatric hospital including 1.8 million patients
- Develop and test methods to detect adverse drug reactions from billing codes, drug prescriptions and lab value results
- Disseminate findings through national and international conferences and in peer-reviewed scientific publications
Basic Qualifications
PhD in computer science, engineering or a related field; Expertise in SQL query language; Expertise in R or Python programing languages
Application Procedure and Requirements
Applications will be accepted until the position is filled. Please include the following when applying: Curriculum vitae; Cover letter and a 2-page description of relevant experience as a single PDF; DOI or PMCID of up to three relevant publications. Selected candidates will be asked to provide letters of reference.

Additional Position Description
Host Institution: Harvard Medical School | Appointing Department: Harvard Program in Therapeutic Science |Research Laboratory: Paul Avillach |Location: Boston, MA |Category: Scientist |Other responsibilities: no administrative or teaching obligations |Duration of fellowship: 2 years

Contact: Paul Avillach, MD, PhD, Department of Biomedical Informatics, 10 Shattuck Street, Boston, MA 02115

 

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Postdoctoral Positions in the Lab of Maha Farhat

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Postdoctoral Positions in the Lab of Peter Kharchenko  (posted 2.12.19)
Job Description
The Department of Biomedical Informatics (DBMI) at Harvard Medical School and the Kharchenko Lab is looking to recruit several postdoctoral fellows interested in pursuing one or more of the following topics in computational biology:

Single-Cell Genomics
The fellow will be charged with developing novel statistical approaches to the analysis of single-cell genomic data, mathematical modeling of cellular processes, as well as applications of such techniques to study healthy and diseased tissues. Strong background in statistics, modeling of stochastic processes and multicellular systems is desired.

Computational analysis of epigenetic mechanisms disrupted in cancer and other disease-disrupted tissues
The fellow will be responsible for developing and applying computational methods for integrative analysis of genome-wide epigenetic, transcriptional and proteomic data, aiming to identify specific factors and molecular mechanisms underlying misregulation of the epigenetic states in several types of human cancer. The ideal candidate should have a strong quantitative background, ample experience with analysis of sequencing assays, and strong interest in cancer biology.

All projects are being conducted in close cooperation with the expert bench-side laboratories, providing an excellent opportunity for collaborative research. Harvard Medical School and the Department of Biomedical Informatics also provides for a rich scientific environment, with a number of relevant seminar series, invited speakers, and many neighboring laboratories working on related projects.

PhD in Computational Biology, Statistics, Physics or other related discipline is required. A strong record of publications in the field is desired.

To apply – please send cover letter, curriculum vitae and contact information for at least two references to Dr. Peter Kharchenko at peter_kharchenko@hms.harvard.edu. Applications will be considered until the positions are filled. Please specify which project you are interested in.

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Kharchenko Lab: Postdoctoral Opportunities (posted 1.28.19)
Single-cell Transcriptomics, Epigenetics | Spatially-resolved Transcriptomics | Gene Regulation | Cancer Heterogeneity, Therapy Resistance, Immune Microenvironment | Tissue Organization

A group led by Peter Kharchenko at the Department of Biomedical Informatics of the Harvard Medical School is searching for postdoctoral fellows interested in developing and applying novel statistical, computational and experimental approaches to study challenges posed by cancer biology and development/maintenance of healthy tissues at a single-cell resolution. The research questions are being pursued in close cooperation with expert bench-side laboratories, providing an excellent opportunity for collaborative research. In particular, we are looking for researchers interested in joining our efforts on single-cell atlas of human brain, lung, kidney and other organs as part of the NIH funded BRAIN and HuBMAP consortia. Fellows interested in application of advanced image analysis techniques to study organization of biological tissues are encouraged to apply.

More info at
http://pklab.med.harvard.edu/

Areas of Interest: Single-Cell Analysis, Spatial Analysis, Statistics, Cancer, Tissue homeostasis

Candidate qualifications:
- Robust knowledge of statistical methods, and probabilistic modeling techniques
- Experience with quantitative analysis of modern biological assays
- We welcome experience in image analysis, graphical models, and advanced machine learning
- A strong interest in conducting collaborative research
- Track record of publications in peer-reviewed journals

How to apply: Please send cover letter, curriculum vitae and contact information for at least two
references to Peter Kharchenko at peter_kharchenko@hms.harvard.edu. Applications will be considered until the position is filled.

Employer: Department of Biomedical Informatics has been recently formed at the Harvard Medical School to lead development of computational and informatics techniques to address pertinent challenges in modern biological sciences and medicine. The Department’s faculty conduct research at the intersection of biomedicine and information sciences, including bioinformatics, functional genomics, translational medicine, and clinical knowledge management. The Department also hosts the Bioinformatics & Integrative Genomics PhD program (sponsored by NHGRI) and the Biomedical Informatics Masters program.

Harvard Medical School is an Equal Opportunity/Affirmative Action Employer.

Women and minorities are especially encouraged to apply.

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Gehlenborg Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/gehlenborg-lab

Kharchenko Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/kharchenko-lab

Patel Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/patel-group

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CELL BIOLOGY

The Harper Lab
The laboratory of Wade Harper in the Department of Cell Biology at Harvard Medical School seeks motivated postdoctoral fellows with an interest in the control protein homeostasis via the ubiquitin-proteasome system and autophagy. Organelle and protein quality control underlies many aspects of cell function and defects in these pathways are major contributors to neurodegenerative disease. Indeed, a broad cross-section of familial and sporadic mutations observed in patients with neurodegeneration map to quality control proteins.
The Harper lab uses quantitative proteomics in conjunction with genetically defined cell systems to understand the contributions of protein homeostasis to neurodegenerative disease. Our goal is to elucidate how defects in these functions promote disease and to also use these genetically defined pathways to uncover novel quality control mechanisms. Major systems employ genetically engineered induced neurons designed to reveal mechanistic insights into poorly understood pathways. In addition, parallel efforts are directed to uncover the structure of the human interactome through the creation of the BioPlex protein interaction network (https://bioplex.hms.harvard.edu/).
Successful candidates will join a dynamic motivated team of researchers in a highly creative environment for discovery, and will develop their own area of research within the broad interest within the lab. Work in the lab is funded by the NIH, CZI, Aligning Science Across Parkinson’s, Google Ventures, among others.
Further information about the lab can be found at: https://harper.hms.harvard.edu/ and application instructions can be found at: https://harper.hms.harvard.edu/contact-and-job-opening-information  (posted 8.19.21)

The Silver Lab

Research Associate Department of Cell Biology Harvard Medical School
The Department of Cell Biology at Harvard Medical School is seeking one highly motivated and skilled scientist to join the HMS Cell Biology Initiative for Genome Editing and Neurodegeneration.  The Research Associate will work with a team of scientists who provide genome editing and neural differentiation-related services to the whole department.  These services include consultation, technical instruction, cell line generation, and neural differentiation from human pluripotent stem cells.

The successful candidate will have a Ph.D. degree in biological or biomedical sciences.  Extensive experience in mammalian cell culture and molecular biology is essential.  Experience with human pluripotent stem cell maintenance and differentiation is preferred.  Experience with protein purification andflow cytometryis a plus. You must be self-motivated, able to work independently as well as part of a team, have excellent communication and interpersonal skills, pay attention to detail, and be highly organized.

If you are interested in this exciting career opportunity to work with the vibrant community of cell biologists at Harvard Medical School, please send a cover letter and CV including the names and contact information for three references to initiativehmscb@gmail.com.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. (posted 1.12.21)

 

The Goldberg Lab in the Department of Cell Biology
The Lab of Prof Alfred Goldberg has an opening for a postdoctoral fellow to investigate the cellular mechanisms regulating the activity of the 26S proteasome in mammalian cells. Their recent research has uncovered a new mechanism controlling rates of protein degradation by the ubiquitin proteasome pathway. They showed that drugs and hormones that raise cAMP or cGMP by causing protein phosphorylation enhance its activity and stimulate ubiquitin-dependent degradation of proteins, including the degradation of various misfolded proteins associated with neurodegenerative disease. Thus, these studies are not only of basic biochemical and cell biological interest, but also are suggesting new approaches for the treatment of several neurodegenerative diseases.
Individuals interested in contributing to this research should possess a PhD degree and/or a MD degree with research experience in Molecular Biology, Biochemistry, or Cell Biology. Prior experience in protein chemistry and in studies of protein quality control, the ubiquitin-proteasome system or cellular signaling systems is desirable.
Applicants should write letters of introduction to
Alfred_Goldberg@hms.harvard.edu and should provide their curriculum vitae, a discussion of their interests and future goals, and the names and addresses of three scientists who could provide letters of recommendation.
EEO Statement
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.  (posted 12.1.20)

 

Yuan Laboratory at Harvard Medical School


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CENTER FOR BIOETHICS

Title of Postdoc position:  Research Fellow in Bioethics
Location: Boston, MA | Duration: One year, with the possibility of extension | Salary: consistent with NIH guidelines
Primary supervisor: Gabriel Lázaro-Muñoz, PhD, JD
Position Description:
The Center for Bioethics at Harvard Medical School is hiring a full-time postdoctoral researcher with a strong background or interest in qualitative methods and/or bioethics to work in an NIH-funded study examining the ethical, clinical and legal implications of using polygenic risk scores in child and adolescent psychiatry.  
The postdoctoral researcher will be part of an interdisciplinary team of researchers led by Gabriel Lázaro-Muñoz, PhD, JD, Stacey Pereira, PhD, and Eric A. Storch, PhD. The postdoctoral researcher will have the opportunity to receive mentoring on grant writing.
The specific responsibilities of the position include, but are not limited to, the following:
•    Assist with interview and survey materials development and data collection
•    Conduct interviews and qualitative data analysis
•    Assist with conceptual and ethical analysis
•    Assist with quantitative data analysis, as able
•    Take the lead and assist in the preparation of manuscripts for publication
•    Take the lead and assist in the preparation of presentations to disseminate the project’s research in local, national, and international meetings
•    Perform other duties based on project needs
Basic Qualifications
•    Doctoral degree (e.g., PhD, MD, JD) in philosophy, social sciences (e.g., anthropology, sociology), neuroscience, genetics, health policy, public health, or related field
Additional Qualifications
•    Experience with qualitative data collection and analysis desired; experience with qualitative data analysis programs preferred (e.g., ATLAS.ti, MAXQDA)
•    Experience with quantitative data analysis preferred
•    Strong interpersonal and communication skills required; must be able to work independently and collaboratively to meet deadlines
•    Strong interest in neuroethics, bioethics, health policy, and/or related legal issues
Application Instructions
Interested applicants should submit the following to Gabriel Làzaro-Muñoz (Gabriel_Lazaro-Munoz@hms.harvard.edu) for consideration:
•    CV
•    cover letter outlining interest in the role
•    writing samples or publication examples (up to 3 articles), and
•    names and contact information for three references.
Submit items as one PDF named “[your last name, first initial]_[research area or PI name]-fellow-2019” by [deadline].
The deadline for applications is 9/30/21.  Applications will be reviewed as they are received.  

Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Applications from women and underrepresented minorities are strongly encouraged.

 

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GENETICS

Ting Wu Laboratory - Postdoctoral Position as Image Analyst for Spatial Genomics
We are seeking computational experts to join the laboratory of Ting Wu (Harvard Medical School) in their CEGS
(NIH/NHGRI) journey to image, analyze, and model the human genome at super-resolution. Individuals with extensive computational experience as well as a penchant for innovating and applying tools at all levels of imaging (from high throughput feature extraction and image processing to image analysis and modeling) are encouraged to apply. A strong sense of collaboration and high levels of self-motivation, creativity, and open-mindedness will be appreciated. Experience in machine learning will be advantageous. Candidates can anticipate joining an interdisciplinary team of geneticists, microscopists, chemists, engineers, physicists, and computational experts. We are excited to meet you at the interface of computation, experimentation, and theory.
Qualifications:
•    Expertise in Computational Biology, Data Science, Statistics, and/or related fields.
•    Proficiency in Python, R, and cloud/cluster computing.
•    Familiarity with Machine Learning, Neural Networks, and/or Artificial Intelligence for building, testing, and evaluating predictive and classification models.
•    Strong presentation and communication skills both verbal and written.
For immediate consideration, please submit your cover letter and resume to Sarah Aufmkolk, Ph.D. 
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Disclaimer: Harvard will require COVID vaccination for all Harvard community members who will have any on-campus presence. Individuals may claim exemption from the vaccine requirement for medical or religious reasons. More information regarding the University’s COVID vaccination requirement and exceptions may be found at the University’s “COVID-19 Vaccine Information” webpage: http://www.harvard.edu/coronavirus/covid-19-vaccine-information/  (posted 8.20.21)

 

Yankner Laboratory at Harvard Medical School
The laboratory of Bruce Yankner in the Department of Genetics and the Glenn Center at Harvard Medical School is seeking a postdoctoral fellow to work in a dynamic lab environment in which the candidate will use multiple cutting edge techniques to address fundamental questions in aging and brain disease biology. Areas of investigation include the molecular basis of brain aging, Alzheimer’s disease and neuropsychiatric disorders, as well as novel therapeutic approaches. The laboratory employs a multidisciplinary approach including bioinformatic single cell analysis of the brain, genetically engineered mouse models, iPS cells and cerebral organoid models. Techniques used include molecular biology and CRISPR gene editing, mouse genetics, behavioral analysis, immunofluorescence, neuronal cell culture, electrophysiology and calcium imaging. An M.D. or Ph.D. degree and experience in one or more of these areas are required. The ideal candidate should be creative, able to both lead their own independent project and work with others on collaborative projects in a highly interactive environment. If you are interested in this opportunity, please email a cover letter with a statement of research expertise and interests, a curriculum vitae, and names & email addresses of three references to: Saba Hazaveh - saba_hazaveh@hms.harvard.edu. (posted 8.27.21)

Sinclair Lab
We are seeking a talented, highly motivated researcher to join the laboratory of Professor David Sinclair in the Genetics Department at Harvard Medical School, Boston. The Sinclair lab is known for their work on genes and small molecules that delay or reverse aging. They have identified a new approach to safely reverse the age of tissues and used it to restore the vision of old mice, a study that was recently on the cover of Nature. The lab has a wide range of expertise and interests, including cancer, neurodegeneration, blindness, diabetes, and muscle degeneration.
The position offers an opportunity to work with an engaged group of scientists and participate in cutting-edge research funded by NIH and various private foundations. The ideal candidate will have hands on experience with genetics and genomics, molecular and cellular biology techniques, epigenetics, and small animal husbandry. The candidate will work to understand and utilize epigenetic reprogramming to safely reverse aging and treat both rare and common diseases. This will include both the use of existing approaches and the development of new ones.
Required Skills/Abilities/Competencies:
- A Ph.D. in genetics, molecular biology, biochemistry, genomics, systems biology, or related.
- Strong scientific knowledge of molecular and cellular biology, genetics and epigenetics.
- Experience with small animal husbandry.
- Outstanding personal initiative and creativity.
- Ability to interpret complex data sets and design subsequent experiments.
- Excellent teamwork, time management and organizational skills.
- Ability to work independently in a multidisciplinary, fast-paced, results-oriented environment.
- Talent in presenting data to a multidisciplinary audience in a clear and cohesive manner.
- Ability to meet deadlines and multitask efficiently is a must.
The ideal candidate will have a record of scientific rigor and creativity, a strong publication record in peer-reviewed scientific journals and the ability to work in teams. Excellent oral and written communication skills are required. The individual will present regular updates to academic and industry collaborators as well as prepare and publish research reports. There is a real opportunity to invent and to innovate.
To apply, send cover letter and CV to luis_rajman@hms.harvard.edu  (posted 1.22.21)

 

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GLOBAL HEALTH AND SOCIAL MEDICINE

No positions currently listed.

 

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HARVARD CATALYST

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HARVARD PROGRAM IN THERAPEUTIC SCIENCE (HiTS)

HiTS (Peter Sorger) LSP Project Management Fellow – High Dimensional Imaging of Human Disease
HiTS (Center for Regulatory Science) Postdoc Fellow in Pharmaceutical Policy
HiTS (Center for Regulatory Science) NLP Postdoctoral Fellow  
HiTS (Center for Regulatory Science) Postdoc Fellow in Data Science  
HiTS (Center for Regulatory Science)

Postdoc Fellow in Regulatory Science

 

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HEALTH CARE POLICY

No positions currently listed.

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IMMUNOLOGY

No positions currently listed.

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MICROBIOLOGY

Don Coen's Lab in the Department of Biological Chemistry & Molecular Pharmacology and David Knipe's Lab in the HMS Department of Microbiology are jointly seeking applicants for a postdoctoral research fellow to perform research on mechanisms that regulate whether herpes simplex virus undergoes a productive ("lytic") infection or a latent infection in neurons. Potential mechanisms that might be studied include neuronal factors, epigenetic and chromatin modifications, microRNAs, and translational regulation.   Studies in both cell culture models, including human iPSC-derived neurons and mouse models are anticipated. Experience with one or more of these areas of research, viruses, immunofluorescence and in situ hybridization methods, and/or RNAseq is desirable, but not required.

If you're interested, please send an email explaining your qualifications and interests to Don Coen (don_coen@hms.harvard.edu) and/or David Knipe (david_knipe@hms.harvard.edu) along with your curriculum vitae and the names and contact information of three references. (posted 11.19.20)

Abraham Laboratory at Harvard Medical School

Gehrke Laboratory at Harvard Medical School

Nibert Lab

Yang Laboratory at Harvard Medical School


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NEUROBIOLOGY

Weitz Lab - Postdoctoral position in cryo-EM structural biology at Harvard Medical School
We are seeking an outstanding, highly-motivated postdoctoral fellow to join our team in the cryo-EM structural analysis of the endogenous protein machines comprising the mammalian circadian clock, a molecular oscillator present in all or nearly all cells that drives daily rhythms of gene expression, physiology, and behavior. 

Applicants should have a Ph.D. degree and expertise in biochemistry and structural biology, including experience in cryo-EM structure determination.  Our initial studies (e.g., Aryal et al., Mol. Cell, 2017) provided the first basic structural view of native circadian clock machinery from a eukaryote.  We have made progress in single-particle cryo-EM analysis of native circadian clock complexes purified from mouse tissues, and we aim to obtain high-resolution structures.  A successful outcome would have a revolutionary impact on our understanding of biological timekeeping and help create a new field of research in circadian biology.

Interested candidates should contact Chuck Weitz at cweitz@hms.harvard.edu. Please include a cover letter, Curriculum Vitae, and a brief statement of research expertise and interests (posted 5.7.21)

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Regehr LabPostdoctoral Positions (posted 7.10.20)
The Regehr lab is seeking postdoctoral fellows to work in an interactive lab environment in which the candidate will use multiple cutting edge techniques to address diverse questions. Areas of investigation include: the molecular and functional characterization of synaptic transmission, the behavioral significance of short-term synaptic plasticity, characterization of cerebellar circuitry, and the role of the cerebellum in motor and social behaviors. Techniques used include: slice electrophysiology, calcium measurements, caged neurotransmitters, AAV manipulation, optogenetics, mouse genetics, immunofluorescence, FISH, single unit electrophysiology in awake behaving animals, behavioral analysis (including many social behaviors, gait analysis, Motion Seq, VOR and conditioned eyeblink), serial electron reconstructions (in collaboration with the Lee lab), single cell molecular characterization of neurons in the cerebellum (in collaboration with the Makosco lab), and in vivo 2-photon functional imaging (in collaboration with the Harvey lab). Multiple positions are available. The ideal candidate should be creative, able to both lead their own independent project, and able to work with others on collaborative projects in a highly interactive environment.
Please email a cover letter, a curriculum vitae, and names & email addresses of three references to:
Wade G. Regehr
Department of Neurobiology
Harvard Medical School
Goldenson 307
Boston, MA 02115
Email: wade_regehr@hms.harvad.edu

Website: https://regehrmedharvard.wordpress.com/
(posted 7.10.20)

 

Harwell Lab

 

Born Lab (and Haefner Lab)  

Drugowitsch Lab at Harvard Medical School

Gu Laboratory at Harvard Medical School

Kaeser Lab at Harvard Medical School

Goodrich Laboratory at Harvard Medical School

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SYSTEMS BIOLOGY

Silver Lab
Postdoctoral Fellowship in Next-Generation Anti-viral Therapies
We are seeking Postdoctoral Fellows to join a new collaborative project at Harvard Medical School to develop new targets and strategies for anti-viral therapies.  

Our team: We have recently embarked on a multi-PI effort together with Industry collaborators to identify pan-viral targets and therapeutic molecules. Participating Principal Investigators include Professors Tim Mitchison, Adrian Salic and Pamela Silver. Our multi-disciplinary team combines expertise across computation, synthetic biology, cell biology, and virology. This effort is part of the larger Therapeutics Initiative at Harvard Medical School and, as such, will offer additional learning opportunities around drug development.

The position: You will be one of several (5-8) postdoctoral fellows working as part of our multi-PI team effort. The formal appointment will be in the lab of one of the PIs (to be determined based on your interests and experience). However, you will be expected to work collaboratively with multiple faculty members and the members of their labs.

Expertise in all aspects of the project is not necessary. We are seeking enthusiastic candidates from a diversity of backgrounds who can contribute to this ambitious undertaking. The unique nature of this position offers opportunities to learn more about the cell biology of viruses, to learn more about novel computational strategies for drug development, to learn from and work with industry scientists, and to be part of a synergistic team.

We are equally interested in candidates intending to pursue academic and industry careers, and will support either career trajectory fully. You will have opportunities to contribute to and/or act as lead author on publications arising from this work, to communicate findings in presentations at national and international conferences, and to apply for fellowships, based on your professional interests. The ideal candidate will be excited to seize upon the tremendous opportunities available at Harvard Medical School – including access to numerous faculty and peer mentors – and to leverage these opportunities to strategically and creatively achieve their professional goals within the context of this project.

Term: 1 year. Renewable for 3+
Salary: Consistent with NIH guidelines, with opportunities for accelerated promotion
Start date: ASAP* | Location: Boston, MA*
*Both to be determined based on current covid guidelines

Required qualifications: Doctoral-level degree in a relevant field, with evidence of an ability to excel in research. Good organizational skills. Interest/experience working as part of a collaborative team. Interest/experience working with industry. Degree must be conferred before the appointment can begin.
Desired qualifications (optional): Experience participating in or managing large collaborative projects. Demonstrated commitment to advancing shared project goals. Demonstrated commitment to developing and advancing an individual development plan for success in academic and/or industry research environments (e.g., continuing education, training, attending meetings and seminars, etc).

Application: Please send the following email:
•    Subject line “Pan-viral postdoc” to Meghan_VanOrden@hms.harvard.edu
•    Body of the email: “Dear Professors Mitchison, Salic, and Silver,” + Brief (1 paragraph) description of your experience and career interests.
•    Attachment: A single (1) PDF with filename “Pan-viral postdoc [surname].pdf”
The combined PDF should include a 1-2 page letter outlining your experience and career interests, along with your CV. Please include the contact information for 3 potential references. If you would like, you can include a relevant recommendation letter as part of the combined PDF.

Harvard University is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Applications from women and members of underrepresented minority groups are strongly encouraged.  (posted 3.12.21)

Mootha Laboratory at Harvard Medical School

Megason Laboratory at Harvard Medical School

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HARVARD SCHOOL OF DENTAL MEDICINE 

Yang Laboratory at Harvard School of Dental Medicine

A post-doctoral position is available in the Yang lab based in the Department of Developmental Biology at the Harvard School of Dental Medicine.
The laboratory of Dr. Yingzi Yang has a longstanding and intense interest in defining the functional mechanisms of Wnt, Hippo, and Hedgehog signaling pathways in development and disease pathogenesis including cancer. We are recruiting a motivated postdoctoral fellow to conduct bone or liver research. We use molecular, biochemistry/cell biology and genomic approaches in both mouse models and human specimens. Our research also involves cutting-edge imaging techniques and liver tumor models. Candidates with strong training in the areas of signal transduction, mechanotransduction, liver tumor microenvironment and mouse genetics are particularly encouraged to apply. The positions are funded by NIH and Harvard University.
The candidate should have a PhD degree in biomedical sciences with less than 3 years of postdoctoral experience and a proven record of scientific productivity. Basic skills in molecular biology, genetics and cell biology are required. Duties and responsibilities of the successful candidate will include:

  • strong abilities to work independently and with self-initiative;
  • abilities to vigorously pursue scientific projects, both conceptually and experimentally, with pro-active thinking and action;
  • collaboration with other research staff, supervision and training of lab members;
  • writing and editing of manuscripts, research presentations at departmental seminars and scientific meetings.

Salary will follow NIH and university guidelines.
To apply, please send a brief statement of research interests, CV and contact information of three references to:
Yingzi Yang, PhD |
Yingzi_yang@hsdm.harvard.edu
This position is granted funded and reappointed annually.
The Harvard School of Dental Medicine values diversity among its faculty, is committed to building a culturally diverse intellectual community, and strongly encourages applications from women and minorities. (posted 11.3.20)

 

 

Two Postdoctoral Positions | Harvard Medical School/Harvard School of Dental Medicine | Drs. Baron and Gori joint Laboratory (Baron-Gori lab)
GENERAL SUMMARY: Two Postdoctoral positions are available in the joint laboratory of Dr. Baron and Dr. Gori, Division of Bone and Mineral Research, Department of Medicine, Harvard Medical School/ Harvard School of Dental Medicine. The longstanding interest of our laboratory is to understand the molecular, cellular and genetic basis of bone growth and remodeling and the regulation of skeletal homeostasis in health and disease in humans, using animal models. The focus of one of these positions is to study the biology of the periosteal surface. In particular, our objective is to identify the role of Sfrp4, a Wnt signaling inhibitor we have shown to be implicated in Pyle Disease, in the expansion, differentiation and/or function of periosteal stem and osteoprogenitor cells. The focus of the other position is to examine novel signaling mechanisms by which PTH regulates Wnt signaling, increases bone formation rate and represses bone marrow adipose tissue and its role in the anabolic action of PTH/PTHrP in bone. A separate aspect of this work is to understand the role of osteocyte biology in the responses to PTH/PTHrP. Our laboratory aims for excellence in research and makes all efforts to publishing its work in the top tier scientific and medical journals. Training of young scientists is also a key aspect of our laboratory, with a very successful history.

The Baron/Gori laboratory is currently funded by three NIH institutes: NIDCR (Gori), NIDDK and NIAMS (Baron) as well as by other sources.

EDUCATION AND EXPERIENCE REQUIRED: The applicants must have a PhD degree. Combined MD/PhD or DDS-DMD/PhD degrees are a plus. We seek highly motivated young scientists who can work independently with strong written and oral communication skills. These projects involve the use of genetically engineered mice, cell and molecular biology and bioinformatic techniques as well as culture of primary cells and cell lines. Commensurate with experience, first author publication(s) in top-tier bone and/or cell and molecular biology journals, expertise in signal transduction analysis, FACS analysis and/or large-scale data analysis, specifically bulk and single cell RNA-seq, will be considered a plus. Prior experience in skeletal research in addition to the above skills is a plus but not a requirement.

APPLICATION REQUIREMENTS: To apply for this position, please email a cover letter, C.V. and three reference contacts to: Francesca_gori@hsdm.harvard.edu and Roland_Baron@hms.harvard.edu (posted 7.30.20)

 

KOTA LABORATORY
Kota Laboratory at Harvard School of Dental Medicine. A postdoctoral position is available to study mono-allelic gene expression and epigenetic gene regulation of skeletal diseases.
Projects will be focused on understanding the regulation of gene expression in ES cells, MSCs and mouse models of skeletal disease.

Successful candidates will have a strong background in molecular biology, cell biology, and biochemistry. Experience and knowledge in ES cell culture, molecular biology techniques commonly employed in RNA, chromatin analysis, protein biochemistry, RNA-seq, Chip-seq , NGS data analysis and mouse genetics are preferred. The candidate will be expected to work independently and have excellent written and verbal communication skills. This position is granted funded and reappointed annually. The Harvard School of Dental Medicine values diversity among its faculty, is committed to building a culturally diverse intellectual community, and strongly encourages applications from women and minorities. Basic Qualification: PhD in molecular biology, bio-chemistry or cell biology is required.

Additional Qualification: Experience with data analysis and statistical/programming packages (SQL, R, and Linux) preferred. Some prior research experience in public health preferred. Interested candidates can send CV, a brief description of research experience, and contact details of 3 references to: Dr. Satya Kota by email: satya_kota@hsdm.harvard.edu  (posted 6.3.20)

 

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WYSS INSTITUTE (Department job site)

Postdoctoral Fellows Positions at the Wyss Institute for Biologically Inspired Engineering
Visit the Wyss Institute's website to find out positions available: https://wyss.harvard.edu/careers/academic/

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