Open Postdoc Positions

Postdoctoral Positions at HMS Quad-based Labs

The Dean's Postdoctoral Fellowship | Curriculum Fellows ProgramBiological Chemistry and Molecular Pharmacology | Biomedical Informatics | Cell Biology | Center for Bioethics | Genetics | Global Health and Social Medicine | Harvard Catalyst | Health Care Policy | Microbiology and Immunobiology | Neurobiology | Systems Biology | Harvard School of Dental Medicine | Wyss Institute

This page lists some of the postdoctoral positions currently available on the HMS Quadrangle. Many principal investigators do not advertise their postdoctoral positions with us, so if the PI you want to work with isn't listed here, please contact her/him directly. Please do not send your CV to the administrator of this page.
For non-Quad or external positions please see: postdoc.hms.harvard.edu/announcements

Quad Departments: to have an opportunity listed on this page, send along a description of the postdoctoral position and contact information to us at postdoc_office@hms.harvard.edu.

Postdoc openings at other Harvard affiliated institutions:
Beth Israel Deaconess Medical Center | Brigham & Women's Hospital | Children’s Hospital | Dana-Farber | Joslin | Mass General Hospital * | McLean Hospital* | T.H. Chan School of Public Health*
*Please note: some Harvard affiliates do not advertise individual postdoc positions with us, it may be best to identify a PI conducting work in your specific area of interest, and to email that PI directly with your CV and cover letter.


~FEATURED FELLOWSHIP OPPORTUNITIES~

The Laboratory of Systems Pharmacology at Harvard Medical School

The Project Management Fellows Program provides postdoctoral fellows with a mix of hands-on and curriculum-based training in the facilitation of complex research in academic and industrial settings. Many NIH-funded research centers mandate or strongly encourage the inclusion of scientific managers and coordinators in research. This creates new career opportunities for skilled scientists interested in supporting the interdisciplinary, multi-investigator projects typical of contemporary biomedical science. The LPM program helps individuals take advantage of this opportunity by providing hands-on and curriculum-based training in facilitating complex research projects.

The Laboratory of Systems Pharmacology (LSP) at Harvard Medical School tackles difficult problems in translational biomedicine using systems pharmacology approaches that combine laboratory experiments, computer science and clinical studies. Within the LSP, experts in systems biology, basic and translational pharmacology, cell biology, infectious disease, clinical trials, and informatics work closely together to meet the goals of ambitious research programs funded by NIH center and program grants.
LSP projects involve collaboration among multiple faculty members, staff scientists and trainees with very different sets of skills and often based in different departments or institutions. These multi-investigator projects are facilitated by PhD-level scientific managers who help coordinate and integrate the different aspects of each large research project, including pipelines for managing diverse omic data, reagent verification, data curation and validation and communication with the larger scientific community. Scientific program managers play a key role in writing reports for funding agencies, coordination of scientific meetings and often contribute to scientific papers. The LSP scientific program managers will provide LPM fellows with guidance, peer support and mentorship through formal and informal mechanisms.

The Project Management Fellows Program
LPM Fellows will have the opportunity to acquire and refine the required for the effective coordination of large collaborative projects, and obtain Project Management Professional (PMP) certification, a designation required or strongly preferred by employers in industry and government.
Each LPM Fellow will gain hands-on experience in the coordination of multiple research projects and learn the basics of grant management by supporting an NIH Center or Program Project research team within LSP. Fellows will also engage in a rigorous professional development program that draws directly on and supports their project management role in the LSP. Fellows will complete the MassBio Project Management for Biotech course (8 evenings), LSP-based skills assessment and communication workshops, and will be expected to enroll in other short courses at Harvard University specific to their own interests (e.g. “Research administration of sponsored awards”, “Difficult conversations”, “Introduction to management in research”, “Managing up”). The Fellow will independently prepare for the Project Management Exam using the Lynda preparatory courses and other resources.  All expenses related to training and examination will be covered.
A successful LPM Fellow will, within a 2-3 year training period:
-Demonstrate their ability to facilitate complex research projects,
-Hone written and verbal communication skills,
-Develop a working relationship with funding agencies,
-Engage a network of peers and mentors regionally,
-Become certified as a Project Management Professional.

The skills the Fellows will acquire can provide opportunities for several career paths, including:
-Managing a research program, center or other similar activity in academia, in partnership with a faculty leader.
-Project management for biotech or pharmaceutical industry laboratories.
-Research administration in academe, government or industry
-Program management in a federal agency such as NIH or NSF.

The LINCS LPM Fellowship
The LSP is recruiting a LPM Fellow in support of the NIH Library of Integrated Network-based Cellular Signatures (LINCS)Center based in the LSP (http://lincs.hms.harvard.edu). The HMS LINCS Center was established in October 2010 to develop experimental and computational strategies to identify cell “signatures” that describe how cells respond to different chemical or biological perturbations. As of March 2017, seven centers across the U.S. participate in the NIH LINCS consortium program. The HMS LINCS Center is identifying signatures that measure the responses of cells derived from different human tissues to therapeutic drugs. Much of the work focuses on cultured cells (from breast, liver and colon), but the Center also studies primary human cells from normal and diseased patients.  As perturbing agents, the focus is on small molecule kinase inhibitors, which are a leading class of therapeutic agents for treatment of cancer, autoimmune and other diseases.
In their research management role, the fellow will collaborate with HMS LINCS investigators to:
-Play a prominent role within the HMS LINCS group curating and organizing experimental data.
-Develop and execute plans for LINCS data releases to public repositories.
-Help to coordinate HMS LINCS data production, data annotation and outreach activities with the work of other LINCS centers.
-Participate in LINCS consortium activities, including regular calls for the Steering Committee, Data Working Group, and Experimental Working Group, and in-person meetings.
-Communicate with the NIH program office regarding required reports, data releases, outreach activities and metrics collection.
-Attend and participate in LSP and Sorger lab group meetings and in the regular and ad hoc meetings involving LINCS PIs, postdocs, students and staff
The Fellow will be appointed as a postdoctoral fellow under LINCS PI and LSP Director Peter Sorger, work on a day-to-day basis with postdocs and staff active in LINCS and receive mentorship and guidance from LSP Scientific Managers and Executive Director.  This position will have a high degree of independence, and opportunities to present at regional and national scientific symposia and workshops.

Requirements:
-PhD in cell biology, biochemistry, molecular biology, pharmacology, systems biology, chemical biology, biophysics or related field
-Demonstrated experience or a strong statement of interest in collaborative research
-Excellent written and verbal communication skills
-Strong organizational and interpersonal skills
-Interest in research coordination and project management

Applications should provide a CV, cover letter and 3 letters of recommendation via email to hits@harvard.edu.

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The Dean's Postdoctoral Fellowship

Co-Sponsored by: The Office for Diversity Inclusion and Community Partnership and The Office for Postdoctoral Fellows

As part of an effort to promote a diversity of backgrounds, perspectives, and experiences among its faculty and trainees, Harvard Medical School invites applications for the Dean’s Postdoctoral Fellowship.
The Office for Diversity Inclusion and Community Partnership in collaboration with The Office for Postdoctoral Fellows will award two-year postdoctoral fellowships per year to two promising researchers in the fields of basic or social sciences. The Dean’s Postdoctoral Fellowship at Harvard Medical School will prepare postdoctoral scientists, particularly scientists from minority and disadvantaged backgrounds, for cutting-edge research careers.  This fellowship will position the right candidate to make major contributions as scientific and societal leaders.
Fellows will benefit from a highly innovative and creative research environment that emphasizes scientific rigor, collaboration, and the pursuit of excellence in science.  In addition, Fellows are welcome to join the HMS the Society for Translational and Academic Researchers (STARs), sponsored by the Office for Diversity Inclusion and Community Partnership
 (https://mfdp.med.harvard.edu/stars)
For more info or to apply: http://www.hms.harvard.edu/dcp/deanspdfellowship/index.html

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The Harvard Medical School Curriculum Fellows Program (CFP)

(listed 5.3.18)

Curriculum Fellow in Translational and Biomedical Sciences
Institution: Harvard Medical School
Location: Boston, MA
Category: Faculty – Science
Type: Full Time
The Harvard Medical School Program in Graduate Education invites applications for a Curriculum Fellow (CF) in Translational and Biomedical Sciences. The Curriculum Fellow will provide broad curricular and academic support to the Leder Human Biology (LHB) program, a translational medicine certification for PhD students enrolled in the biomedical sciences.
Responsibilities
Work closely with the faculty directors of the Leder Human Biology program at Harvard Medical School to organize, teach, and evaluate courses required for the translational medicine certification
Serve as Associate Course Director in BCMP 234 (Cellular Metabolism and Human Disease), one of the required semester-length courses for the LHB Progam. Manage and mentor the course’s Teaching Fellows and help lead critical reading sections
Provide support and guidance for student-organized para-curricular activities associated with the Leder Human Biology program
Catalyze and evaluate initiatives to improve biomedical education across Harvard Medical School, and make evidence-based recommendations to faculty and teaching staff on curricular design
Help to develop and implement a new course on Case Studies in Human Biology
Qualifications

  • An earned doctorate in a field relevant to biology, biochemistry, or the biomedical sciences
  • Experience teaching graduate or undergraduate science courses
  • Advanced knowledge of or training in translational biomedical sciences (preferred)
  • Postdoctoral research in a field relevant to the translational sciences (preferred)

Job Skills and Competencies

  1. Ability to work collaboratively with multiple faculty with the purpose of organizing a semester-long course in cellular metabolism and human disease
  2. Experience applying evidence-based teaching methods and technological innovations to the classroom and working with faculty members to develop effective teaching strategies
  3. Strong organizational and management skills
  4. Commitment to the professional development and mentorship of PhD students in the Leder Human Biology program
  5. This CF position is well suited to an academically-minded scientist who is passionate about graduate biomedical education and is looking to grow their pedagogical expertise, gain hands-on experience designing and teaching graduate courses, and influence the training outcomes of Harvard Medical School’s graduate students. The CF in Translational and Biomedical Sciences will be a member of the HMS Curriculum Fellows Program, a science education community that functions as a training program for early career scientist-teachers. Pedagogical training is incorporated into the fellow’s course- and program-based efforts and includes opportunities to design and conduct discipline-based educational research either in or outside the context of the fellow’s core service to the Leder Human Biology program. CFs receive mentorship and career advising to support their development as educators throughout the duration of the appointment.

To apply
To be considered for this position, please email a single PDF document containing (1) a letter of application that addresses your interest in and qualifications for the position, (2) a curriculum vitae, and (3) a statement of teaching philosophy. Please also include the names and contact information of three references, who will be contacted during the review of candidates. The CF position and its associated academic appointment is a one-year appointment, renewable for up to three years, and is non-tenure-track. Fellows are hired at the rank of research associate with the potential of promotion to Lecturer. Applications will be reviewed on a rolling basis, starting immediately. Applications should be received not later than June 1st, 2018 to ensure full consideration. The ideal start date for this position in August 1, 2018 in Boston, MA.
For details about the Curriculum Fellows Program, please see:
https://curriculumfellows.hms.harvard.edu/
Address applications to:
Bradley Coleman, Ph.D.
Co-Director, Curriculum Fellows Program
Via Ms. Naima Abdullahi (cfp@hms.harvard.edu)
Harvard University is an equal opportunity employer


(listed 4.9.18)

Curriculum Fellow for the Master of Medical Sciences in Immunology
Institution: Harvard Medical School
Location: Boston, MA
Category: Faculty – Science
Type: Full Time
The Harvard Medical School (HMS) Program in Graduate Education invites applications for a Curriculum Fellow (CF) supporting the Master of Medical Sciences (MMSc) program in Immunology. For more information about this graduate program see http://mmscimmunology.hms.harvard.edu/. The primary focus of this position will be the development of graduate-level curriculum in immunology for the students in the MMSc program in immunology, with additional responsibilities overseeing TAs in the Harvard Immunology PhD program.
Responsibilities
--Collaborate with program faculty to develop and revise the curriculum for three graduate level courses in immunology:
--An immunology methods course, with a primer in core molecular, cellular and quantitative biology concepts
--A course focused on reading primary literature and science communication
--A graduate-level introduction to immunology taken by both MMSc and PhD students.
--Serve as an instructor in courses 1 and 2 above.
--Serve on the admissions committee for the MMSc program and conduct interviews with applicants.
--Work with program leadership to oversee other aspects of the training program, including student advising and paracurricular programming.
Qualifications:
-An earned doctorate in immunology or a closely related field
-Experience teaching graduate or undergraduate students
-Advanced knowledge of molecular biology and immunology research methods, such as flow cytometry (preferred)
-Postdoctoral research and/or teaching experience (preferred)
Job Skills and Competencies
--Ability to work collaboratively with multiple faculty and administrative partners to develop new courses and educational/training opportunities
--Experience applying pedagogical best practices to the classroom, including evidence-based teaching methods and technological innovations
--Ability to work independently to identify and implement optimal solutions to diverse problems
--Strong oral and written communication skills, strict attention to detail
--Strong organizational and administrative skills
--Effective mentorship skills
This CF position is well suited to an academically-minded scientist who is passionate about graduate biomedical education and is looking to grow their pedagogical expertise, gain hands-on experience designing and teaching graduate courses, and influence the training outcomes of Harvard Medical School’s graduate students. The CF for the MMSc in Immunology will be a member of the HMS Curriculum Fellows Program, a science education community that functions as a training program for early career scientist-teachers. Pedagogical training is incorporated into the fellow’s course- and program-based efforts and includes opportunities to design and conduct discipline-based educational research (DBER) either in or outside the context of the fellow’s core service to the MMSc in Immunology program. CFs receive mentorship and career advising to support their development as educators throughout the duration of the appointment.

To apply
To be considered for this position, please email a single PDF document containing (1) a letter of application that addresses your interest in and qualifications for the position, (2) a curriculum vitae, and (3) a statement of teaching philosophy. Please also include the names and contact information of three references, who will be contacted during the review of candidates. The CF position and its associated academic appointment is a one-year appointment, renewable for up to three years, and is non-tenure-track. Fellows are hired at the rank of research associate with the potential for promotion to Lecturer. Applications will be reviewed on a rolling basis, starting immediately. Applications should be received no later than May 1st, 2018 to ensure full consideration. The ideal start for this position is June 2018, in Boston, MA.

For details about the Curriculum Fellows Program, please see https://curriculumfellows.hms.harvard.edu/.

Address applications to:
Bradley Coleman, Ph.D.
Co-Director, Curriculum Fellows Program
Via Ms. Naima Abdullahi (cfp@hms.harvard.edu).
Harvard University is an equal opportunity employer.

 

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~DEPARTMENTAL LISTINGS~

BIOLOGICAL CHEMISTRY AND MOLECULAR PHARMACOLOGY

The Arthanari Lab
The Arthanari Lab at Department of BCMP, Harvard Medical School and Department of Cancer Biology, Dana Farber Cancer Institute is seeking a highly motivated postdoctoral candidate with expertise in transcriptional biology. Our laboratory works at the interface of structural biology, drug discovery and mechanistic biology, focusing on transcription factors and their interactions with co-activators and mediators (e.g. Nature 2016 25;530 (7591): 485-9; Nature 2008 452 (7187): 604-9). Research efforts will be focused on the intersection of cancer biology/genetics and immune-oncology. The candidate is expected to have a comprehensive understanding of signaling pathways, epigenetics and transcription regulation. Experience in technical skills including cell culture, somatic genetic analysis (e.g., CRISPr, si-, sh- RNA knockdown and rescue), protein biochemistry, assay design and development and biological applications to advance discovery are preferred. The individual should be independent and passionate about science and have an established record of creativity, ability to work in teams and strong publication record in peer-reviewed scientific journals.
Interested applicants should send a CV, and the names/phone numbers of three references by email to hari@hms.harvard.edu

Blacklow Laboratory at Harvard Medical School
The Blacklow Laboratory at Harvard Medical School (Department of Biological Chemistry and Molecular Pharmacology) has an opening for a Postdoctoral position. The laboratory currently investigates structure-function relationships in Notch signaling, its downstream targets, and its epigenetic regulators.
Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry, Structural Biology or a related field.
Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to jobs_blacklowlab@hms.harvard.edu.

The Brown Laboratory
Postdoctoral Fellow in Electron Cryomicroscopy (Full posting: https://brown.hms.harvard.edu/jobs/93)
Position Description: A postdoctoral position is available in the Brown lab at Harvard Medical School. The lab uses the latest developments in cryo-EM to understand biological processes at the molecular level (e.g. Nature 524, 493–496 and Science 346, 718–722). The project will involve investigating the structure and function of large macromolecular complexes involved in cellular transport. This includes all steps from construct design to structure determination. In the long term, we aim to use detailed molecular models to facilitate the development of new and better therapeutics.
Job requirements: Applicants should hold (or will be shortly awarded) a PhD degree and have experience in molecular biology and protein purification. Prior experience with single-particle cryo-EM or X-ray crystallography is considered a major advantage. Candidates should have strong communication skills and an established record of creativity through principal authorship in peer-reviewed publication(s). The successful candidate should be passionate about science, motivated, proactive, and able to work in a team. While each lab member has their own project, lab members are encouraged to work together to solve common problems. A separate position is available for an outstanding candidate with expertise in electron cryotomography (cryo-ET).
The position is initially for 2 years with a possibility of extension.
If you’re interested in joining the lab, please send your CV with a brief description of your current research as well as 2-3 contacts for references to Alan_Brown@hms.harvard.edu before the 8th August, 2017.

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BIOMEDICAL INFORMATICS

Department of Biomedical Informatics Postdoctoral Position (posted 7.19.18)

Summary
This position will be based in the Department of Biomedical Informatics at Harvard medical school and will supervised by Andrew Beam, PhD (faculty in the Department of Biomedical Informatics) and Isaac Kohane), MD/PhD (chair of the Department of Biomedical Informatics. The candidate will conduct original research on an exciting problem in the domain of medical question answering and will join a team of researchers working on similar problems in the area of natural language understanding. For this project we have curated a unique data resource of nearly 20,000 medical questions and over 200GB of medical text documents. The goal of this project is to create a cutting-edge system that is capable of answering medical questions posed as free text. 

Qualifications
Candidates must have a PhD or other advance degree in statistics, computer science, biomedical informatics, or a related field. The candidate must have expertise in machine learning and experience programming deep learning models using either tensorflow/keras or pytorch.

Additionally, candidates are required to have expertise in deep learning and natural language processing as evidenced by at least one of the following:
- First-author publication in journal or conference in the field of deep learning or NLP
- First-author preprint of a deep learning/NLP project
- A well-documented github repository of a project written either in tensorflow or pytorch implementing a state of the art NLP model (such as a language model, transformer network, fast text, etc) with an accompanying blog post demonstrating the concepts.

Preferences
Strong preference will be given to candidates with previous experience in the area of automatic question answering. Experience with reinforcement learning, knowledge bases, and medical ontologies is also desired.

Responsibilities
The candidate will be responsible for developing new methodology in the field of question answering and reducing these ideas to practice in python code. They will be expected to collaborate with other members of the lab, present their progress regularly at lab meetings, and to communicate their results to the scientific community through profession meetings and scientific publications.

Start Date
As soon as possible
How to Apply
To be considered for this position, please email a single PDF document containing a letter of application that addresses your interest in and qualifications for the position, and a curriculum vitae. Please include the names and contact information of three references, who will be asked to supply letters or will be contacted by phone early in the application process. This is a one-year term appointment with the option to renew for a second-year conditional on satisfactory performance. The position is available now at Harvard Medical School in Boston.
Address applications to:
Andrew Beam, Ph.D.
Instructor in Biomedical Informatics
Andrew_Beam@hms.harvard.edu
Harvard University is an equal opportunity employer.  Women and minorities are especially encouraged to apply

Avillach Laboratory at Harvard Medical School

Research Fellow Position at the Department of Biomedical Informatics (posted 10/16/15)

Description: The Department of Biomedical Informatics (DBMI) at Harvard Medical School is looking for a Research Fellow to help us build cutting edge research platforms. We seek an individual to work on our multidisciplinary team of data scientists, medical doctors, and developers. Our team studies large and disparate datasets from the domains of biology, healthcare and social media. The goal of our efforts is to transform healthcare and research to usher in a new age of individualized data driven medicine.
The Research Fellow will be responsible for developing novel methodologies and applications to help visual causal relationships in bioinformatics data sets. The diversity of subject matter will require a creative mind and a candidate capable of deploying imaginative strategies and who is dedicated to solving complex and challenging problems within an interdisciplinary environment.
Specific responsibilities for this position include:
• Work to understand data about causal relationships in order to develop visualizations.
• Create prototypes for visualizations and work with software professionals to integrate the work into an existing platform.
• Perform novel research on bioinformatics data sets and publish any findings.

For details and additional information: http://avillach-lab.hms.harvard.edu


Gehlenborg Laboratory at Harvard Medical School

Multiple postdoctoral fellowships are available immediately in the Gehlenborg Lab in the Department of Biomedical Informatics at Harvard Medical School. (posted 10/21/15)

Description:
The goal of the lab is to improve human health by developing computational techniques and interfaces that enable biomedical and clinical investigators to efficiently interact with biomedical data. We design, implement and evaluate methods and tools that leverage the knowledge and cognitive skills of investigators in order to enable the interpretation of massive heterogeneous data sets that integrate genomic and clinical data. Please see http://gehlenborglab.org for additional information about our work.

Possible research projects include development of data visualization, analysis, and management tools to study genomic structural variants, dynamics of the 3D genome, and cancer subtypes in patient cohorts. Further projects involve the design and implementation of visual exploration tools for biomedical data repositories and tools for viewing and interacting with provenance graphs. All of the projects are highly interdisciplinary and are being conducted in close cooperation with computational or experimental domain experts providing an excellent opportunity for collaborative research.

Our lab in the Department of Biomedical Informatics is part of a vibrant community of scientists, physicians, and engineers whose goal is to advance the boundaries of knowledge. The Department has recently been formed at Harvard Medical School to lead development of computational and informatics techniques to address pertinent challenges in modern biological sciences and medicine. The Department’s faculty conduct research at the intersection of biomedicine and information sciences, including bioinformatics, functional genomics, translational medicine, and clinical knowledge management. Based on the Harvard Medical School Longwood Campus, it provides a rich scientific environment, with many seminar series and invited speakers of the highest caliber.

For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/gehlenborg-lab

Kharchenko Laboratory at Harvard Medical School

A laboratory at the newly-formed Department of Biomedical Informatics at the Harvard Medical School (HMS) is looking to recruit several postdoctoral fellows interested in pursuing one or more of the following topics in computational biology:
I. Single-Cell Genomics
II. Computational analysis of epigenetic mechanisms disrupted in cancer and other disease-disrupted tissues
III. Computational analysis of nucleosome organization
(posted on 2/4/16)

For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/kharchenko-lab

 

Patel Laboratory at Harvard Medical School

The Patel Group in the Harvard Medical School Department of Biomedical Informatics (http://chiragjpgroup.org) is looking for a Post-Doctoral research fellow to run a collaborative study with Northeastern University’s Antimicrobial Discovery Center that will uncover the characteristics of Lyme disease around the US leveraging emerging large and high-dimensional clinical data streams. Candidates must have a PhD in computer science, mathematics, physics, biomedical informatics, bioinformatics, or a related quantitative field. Preferred qualifications for this position include experience designing large software applications and infrastructure to store, retrieve, and analyze large datasets. Industry experience with R, Python, SQL is required. Experience in hacking with cloud technologies is great. Email applications including curriculum vitae, summary statement of personal objectives, and the names and email addresses of 2-3 references to Chirag Patel (chirag_patel@hms.harvard.edu). Harvard Medical School is an Equal Opportunity/Affirmative Action Employer. Women and minorities are especially encouraged to apply. (posted 3/2/16)

Biomedical Data Scientist Postdoctoral Associate (posted 2/4/16)
Imagine a dynamic dataset that encompasses comprehensive information about a patient in the health care system: what diseases they have, their genomic sequence, their social media messages (e.g, tweets and likes), and where they live. How would you—a data hacker—store, retrieve, and analyze this information to drive biomedical discovery to find a new way of predicting disease or even a new therapy for a disease? Chirag Patel’s Group at the Department of Biomedical Informatics at Harvard Medical School is looking for a data engineer to build cutting-edge platforms and data infrastructure to enable large-scale data-driven research to address this question. We aim to integrate diverse data sources from geotemporal information (e.g., NOAA Weather Data, EPA AirData), individual genomic sequence, social media data, and health claims information to paint a comprehensive picture of individuals who are sick and healthy.

For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/patel-group


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CELL BIOLOGY

Yuan Laboratory at Harvard Medical School
The Yuan laboratory at Harvard Medical School (Department of Cell Biology) has an immediate opening for a postdoctoral scientist. Our laboratory investigates the molecular mechanisms of cell death, including necroptosis and apoptosis, and their relevance for human diseases. This position is for a highly motivated individual with considerable experience in cell biology or related field. Experience in animal models of human diseases is desirable but not required.

Applicants should possess a Ph.D. and/or M.D. degree in molecular biology, cell biology, biochemistry, or neurobiology and a strong publication record. Interested individuals should send a curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to junying_yuan@hms.harvard.edu.

For additional information please visit our webpage: https://yuan.med.harvard.edu/


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CENTER FOR BIOETHICS

The Harvard Medical School Center for Bioethics invites applications for the Postdoctoral Research Scholars Program in Bioethics, for appointments commencing in summer/fall 2018.

This 1-2 year program prepares scholars with the knowledge and skills necessary to become leaders in the field of bioethics. Research scholars are fully integrated into the community of faculty and students at the Center for Bioethics, with access to the resources of Harvard Medical School and Harvard University. The program includes opportunities to collaborate with the scholars at the Hastings Center. We are particularly focused on attracting candidates with an interest in working on ethical and policy issues in regenerative and synthetic biology, genetic engineering, stem cell biology and embryology. Ideal candidates would be promising scientists in these areas with a background in bioethics or with a serious commitment to gaining expertise in the field
Research scholars will receive an annual stipend, benefits, and an allotment for academic expenses and travel.

The core experience includes:

  • Mentored research. Research scholars work closely with faculty mentors from across Harvard University to develop and conduct original research in the field of bioethics. A primary aim of the program is to prepare candidates with the training necessary to obtain competitive research funding and develop a successful academic career in bioethics.
  • Educational opportunities. The program seeks candidates with diverse backgrounds, experience, and knowledge. Each scholar works with faculty creating a personalized educational program that will delve into special areas of interest, as well as developing broad expertise in the field of bioethics. Research scholars have access to all the Center's courses and seminars, and may be able to audit relevant courses across Harvard University with faculty permission.
  • Community life. Postdoctoral research scholars will be fully engaged with the activities of the Center and the Harvard-affiliated teaching hospitals. Scholars will organize and conduct conferences and seminars, they will assist in teaching courses in their areas of interest, and will have opportunities to participate on hospital clinical ethics committees and institutional review boards.

In short, the Postdoctoral Research Scholars Program provides the greatest possible access to all that Harvard University has to offer.

Application Requirements:
Applications are invited from those who have or will have completed a doctoral degree (MD, JD, PhD or equivalent) by July 1, 2018. Doctorates may be in any relevant field, including but not limited to public health, psychology, economics, philosophy, sociology, or anthropology.
The deadline for summer/fall 2018 is March 30, 2018. Applications may be considered throughout the year under special circumstances.
Visit the website for application requirements: 
http://bioethics.hms.harvard.edu/postdoctoral-program


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GENETICS

Genetics - Postdoctoral fellow in Aging at Harvard Medical School (posted 6.1.18)

A postdoctoral fellow position is available immediately in the Department of Genetics at Harvard Medical School to study the biology of aging. The position will be funded by a 5-year R01 research grant entitled “Molecular mechanisms by which mild elevation of mitochondrial superoxide extends longevity” under the direction of Dr. Jeremy Van Raamsdonk, in Dr. Monica Colaiacovo’s lab. Dr. Van Raamsdonk, seeks to understand the aging process and to use that information to promote healthy aging and decrease the severity of age-onset neurodegenerative disease. The laboratory primarily uses C. elegans as a genetic model organism, prior to validating results in mouse models.

For a list of publications from Dr. Van Raamsdonk and the Van Raamsdonk lab please see: https://scholar.google.com/citations?user=WEaryu0AAAAJ&hl=en&oi=ao

Required Qualifications:
-Ph.D. in a related field of biology (e.g. genetics, neuroscience, molecular biology)
-Extensive experience working with C. elegans
-Ability to generate transgenic worms from design to cloning to microinjection to integration
-Previous experience with molecular biology techniques (DNA, RNA, protein)
-Ability to work independently and as part of a team
-Ability to lead a research project from design stages to data analysis, figure preparation and manuscript writing
-A passion for scientific research
-Strong organization and time management skills
-Meticulous attention to detail
-Eligible to work/train in the United States

Additional expertise that would be beneficial:
Experience with Crispr-Cas9 genome editing techniques
-Experience and interest in designing experiments based on large scale bioinformatics outputs (ranking candidates, testing biological significance)
-Knowledge of the aging research field
-A strong understanding of genetics
-Experience with other model organisms especially mammalian systems

Application Process:
Interested applicants should email a (1) cover letter, (2) curriculum vitae, and (3) the names and contact information for three references directly to jeremy_vanraamsdonk@hms.harvard.edu.

 

Church Lab at Harvard Medical School

Two different positions posted (as of 4/13/18)

1.
Exciting postdoctoral fellow opportunity in the Church lab: Computational biology for ancient DNA editing job description

The Church lab has a funded opportunity for a postdoctoral scientist to further the development of the lab’s efforts for mammoth de-extinction and also aging research. The scientist in this position will be responsible for devising and optimizing sample preparation and sequencing library generation protocols and acquiring, validating, and analyzing DNA and RNA sequencing data from edited samples for the mammoth and aging research. Beyond these specific projects working in collaboration with two postdoctoral fellows in the lab, this scientist is expected to become a leading resource within the Church lab on analyzing ‘omics’ methods generally, who will consult and collaborate with others both within and outside of the lab on best ways of conducting and developing these exciting projects. The ideal candidate will have a demonstrated record of scientific rigor, ingenuity, and peer-reviewed publications, and be well-organized, self-motivated, and able to work well both in teams and alone. Candidates should have a strong background and experience in computational aspects of high-throughput DNA and RNA sequencing, use of high-throughput omics data in the context of systems and/or synthetic biology projects, and a strong understanding of statistics. Experimental background is a plus but not required. Good oral and written communication skills are required.

Please include the following information in your cover letter:

Are you legally authorized to work in the United States? Will you now or in the future require sponsorship for employment visa status?

Email your cover letter and CV with the following reference code in the subject line: Ref# DNA2018_Apr To: Eriona_Hysolli@hms.harvard.edu

Have any references sent directly from your referee to the same email address.

2.
The Church lab has funded opportunities for postdoctoral scientists to advance two synthetic biology projects funded by the U.S. Department of Energy's (DOE) biofuel generation programs.  To be used in the subject line when applying: DOE2018_APR 

Postdoctoral Fellow in Translation Engineering
The aim of one project is to conduct large-scale reengineering of the protein translation systems of E. coli strains whose genomes have been recoded so that one or more codons are unused, so that proteins containing multiple, distinct non-standard amino acids (NSAAs) (including D-amino acids) can be efficiently generated. The scientist in this position will work with others in the lab to devise and implement ambitious strategies for developing, testing, demonstrating, and optimizing integrated sets of translation system components (such as tRNAs, amino-acyl tRNA synthetases, ribosomal proteins, rRNAs, and associated translation factors), that will operate together or in parallel in support of this goal.

Postdoctoral Fellow in Biosensor Development
The aim of the second project is use synthetic biology, structural biology, and protein engineering methods to alter existing proteins, or de novo design new ones, that respond efficiently and specifically in microbes to small molecules of potential importance or interest to DOE’s program. The scientist in this position will leverage high-throughput computational biology, synthesis, and sequencing methods to generate and screen diverse libraries of biosensor proteins and optimize their products, in ways that either further advance techniques already developed or demonstrated by the lab or work towards new ones, and will also consider how NSAAs might be used in protein redesign.

The scientists in either of these positions are expected to become leading resources within the Church lab on the general techniques and biology relevant to their projects, who will consult and work with others both within and outside of the lab on the best ways of leveraging these methods in related applications or towards other goals. The ideal candidates will have demonstrated records of scientific rigor, ingenuity, and peer-reviewed publications, and will be well-organized, self-motivated, and to work well both in teams and alone. Candidates should be fast learners who have prior experience with sets of high throughput experimental and computational methods that are relevant to the positions for which they apply, should be familiar with high-throughput omics data analysis techniques, and should have a strong understanding of statistics. Experience with technology development of new omics capabilities is highly desirable. Excellent oral and written communication skills are required.

Please answer the following questions below in your cover letter and include your CV and recommendations via email to church_lab_admin@hms.harvard.edu
1. Are you legally authorized to work in the United States? Will you now or in the future require sponsorship for employment visa status?
2. What is your ideal scenario for a postdoc and beyond?
Please to be sure to use this subject line when applying: DOE2018_APR

 

Sinclair Laboratory at Harvard Medical School

Computational Biology/Bioinformatics Post-doctoral position available immediately (posted 8.2.18)
We are seeking a talented, highly motivated individual to join the laboratory of Professor David Sinclair in the Genetics Department at Harvard Medical School, Boston. The
Sinclair lab is known for their work on genes and small molecules that delay aging and treat age-related diseases. The lab has a wide range or expertise and interests, including cancer, neurodegeneration, diabetes, and fertility.

We are seeking a talented individual with a background in computational biology or bioinformatics. The position offers an opportunity to work with an engaged group of scientists and participate in cutting-edge research combining proteomics and genomics. The ideal candidate will have experience working with linux-based bioinformatic software and interactive data analysis environments (Python/R). The position requires expertise in genomics, transcriptomics, or proteomics data analysis. The candidate will work on integrative analysis of many types of omics data, including RNA-seq, ChIP-seq, Hi-C, and Quantitative Mass Spectrometry. The focus of the candidate will be on applying systems biology approaches to diverse data sets in order to address basic and translational research questions surrounding aging and age-associated diseases. This includes both the use of existing data analysis approaches and the development of new approaches and software. The individual will also participate in the development of our proteo-genomics data analysis efforts.

Principal Responsibilities:
- Lead in the development of new methods, tools, algorithms, and pipelines to analyze and integrate genomic, epigenomic, transcriptomic, metabolomic, and proteomic data.
- Work with the molecular biology team to design omics experiments.
- Process, analyze and interpret high volumes of data as part of a wide range of internal and external scientific studies.
- Provide bioinformatics support and consulting to other members of the laboratory.
- Monitor and evaluate new and emerging technologies relevant to the lab (sequencing, proteomics and others).
- Present scientific and technical data to both internal and external scientific colleagues in a clear and cohesive manner.
- Work independently and prepare timetables, deliverables, and project schedules.

Required Skills/Abilities/Competencies:
- Ph.D. in Bioinformatics, Computational Biology, Computer Science, Biology, or related fields.
- Extensive experience in scientific programming/scripting for analysis of biological data.
- Proven understanding and experience in the fields of genomics, high-throughput sequencing, data processing, data analysis, and genomic databases.
- Excellent track record of analyzing next generation sequencing data, particularly WGS, Hi-C, ChIP-seq, and RNA-seq.
- Experience in linux-based environments.
- Experience with statistical analysis is strongly preferred.
- Strong scientific understanding of molecular and cellular biology, genetics and genomics.
- Candidates must demonstrate outstanding personal initiative.
- Excellent teamwork, time management and organizational skills.
- Ability to work independently in a multidisciplinary, fast-paced, dynamic and results-oriented environment.
- Ability to present data to a multidisciplinary audience in a clear and cohesive manner.
- Ability to meet deadlines and multitask efficiently is a must.

The ideal candidate will have a record of scientific rigor and creativity, a strong publication record in peer-reviewed scientific journals and the ability to work in teams.

Candidates should have a strong background in genomics, proteomics and metabolomics. Excellent oral and written communication skills are required. The individual will present regular updates to academic and industry collaborators as well as prepare and publish research reports. There is a real opportunity to invent and to innovate.

To apply, send cover letter and CV to luis_rajman@hms.harvard.edu
 

Yankner Laboratory at Harvard Medical School
Positions available to study gene regulation, epigenetics and the molecular biology of aging and neurodegenerative diseases.  Projects focus on iPS cells, C. elegans, animal models and the biology of genes involved in aging and Alzheimer's disease. For reference see: Nature 507:448, 2014, J. Cell Biol. 203:457, 2013, Mol. Cell 40:333, 2010, Nature 464:529, 2010, Nature 429:883, 2004. Experience in molecular biology is required.

Send CV, a brief description of research experience and names of 3 references to: Dr. Bruce Yankner by email to aharwick@genetics.med.harvard.edu


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GLOBAL HEALTH AND SOCIAL MEDICINE

Global Health Equity Research Fellowship
The Department of Global Health and Social Medicine is seeking a post-doctoral fellow for the two-year Global Health Equity (GHE) Research Fellowship.* The Fellow will join the Harvard Medical School Global Health Research Core, directed by Professor Megan Murray, and will be based at a Partners In Health-supported site in Rwanda joining a multidisciplinary team of practitioners, program managers, policy makers, and researchers. During the fellowship, the fellow will conduct high quality research on health needs and program implementation and support a broader research capacity building program and the mentoring of junior researchers in research methods and results dissemination.

Implementation, operational, and scientific research is a principal mission of the HMS Global Health Research Core and Partners In Health. In 2012, Partners In Health-Rwanda, with the support of the Research Core, launched a comprehensive research capacity building program with the aim to cultivate a culture of research and develop technical skills and research leadership at Global Health Delivery Partnership-supported sites. The research spans a variety of health topics aimed at improving service delivery and health outcomes in Rwanda and in other low and middle income countries. Priority research areas for Partners In Health-Rwanda include women’s health, oncology, non-communicable diseases, HIV, maternal and child health, nutrition, and health systems strengthening. The GHE Research Fellow will develop research within a priority research area(s) and support research capacity building within this topic area.

Successful candidates will have recently completed the PhD (or equivalent) in public health, epidemiology, biostatistics, global health, or a related field. Applicants should have 1) strong quantitative skills, 2) strong scientific writing and communication skills, and 3) previous teaching experience. Experience living/working in a cross-cultural environment and French fluency are preferred.

*The appointee would be employed by Harvard Global Support Services.

Anticipated start date: May 1, 2018 or as soon as possible | Salary range: US$50-55,000 | Relocation costs are negotiable

Interested applicants should send their cover letter, CV, and contact information for three references in one PDF named “[your last name, first initial]_GHE-fellow-application-2018” to Rebecca Grow (email: rgrow@hms.harvard.edu).

For additional information see:
HMS Global Health Research Core (https://hms.harvard.edu/departments/global-health-research-core)
Global Health Delivery Partnership (http://ghsm.hms.harvard.edu/about-us/partners)
Partners In Health (https://www.pih.org/)

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HARVARD CATALYST

No positions currently listed.

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HEALTH CARE POLICY

No positions currently listed.

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MICROBIOLOGY AND IMMUNOBIOLOGY

Nibert Lab
August 20, 2018 - Postdoc Position available immediately

Available position: Postdoctoral research associate
Location: Nibert lab, Department of Microbiology, HMS (NRB-939, 77 Ave Louis Pasteur)

Project: Molecular biology of Trichomonas vaginalis viruses, including genomic characterizations, dissection of packaging/replication/translation signals, and structure-function studies of virus particles and proteins
Job Responsibilities include: Working collaboratively to design experiments, perform experiments, analyze data, present data to academic colleagues, prepare manuscripts.

Please email a CV, cover letter, and names of at least two references to:
Max Nibert, Professor of Microbiology
mnibert@hms.harvard.edu


Abraham Laboratory at Harvard Medical School
The Abraham Lab in the Department of Microbiology and Immunobiology at Harvard Medical School is seeking a highly motivated postdoctoral candidate with expertise in molecular biology and protein biochemistry. Our laboratory uses methods in structural biology, human immunology, and virology, to study on how emerging pathogens interact with host cells and are neutralized by antibodies (e.g. Cell Host & Microbe 18, 705–713, 2015).
Interested applicants should send a CV, including the names/email addresses of three references, to
abraham@crystal.harvard.edu


Gehrke Laboratory at Harvard Medical School
The Gehrke laboratory is looking for a U.S. citizen postdoc to join a team that is studying neurotropic virus infections using 2D and 3D tissue models.  Applicants must have Ph.D. or M.D. degree with a background in virology and familiarity with molecular techniques.  The work will involve BSL3 pathogens. Available immediately. Please send inquiries to lee_gehrke@hms.harvard.edu. (6.2.17)


Yang Laboratory at Harvard Medical School
The Yang Lab has two immediate openings for postdoctoral fellows to play a vital role in the discovery and optimization of small molecule antivirals. Must have established expertise in protein expression (microbial, insect, and mammalian cells) and purification as well as with a variety of biophysical and biochemical methods for characterizing protein-small molecule interactions. Experience with high-throughput screening and/or molecular virology techniques is desired but may be substituted with a willingness and aptitude to learn. Must be willing to work with viral pathogens in a BSL2+ lab.

You will be working within a multidisciplinary group of structural biologists, medicinal chemists, biochemists, and virologists. This position requires excellent communication and organizational skills, and a willingness to help train and mentor more junior members on the research team. This is an excellent opportunity for a post-doctoral fellow to acquire experience relevant to future employment in industry while still operating within an academic environment. This position is funded by an NIH grant through 2018. Applicants are expected to make a 3 year commitment.

Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Priscilla L. Yang., Ph.D.
Department of Microbiology and Immunobiology
Harvard Medical School
Email: Priscilla_yang@hms.harvard.edu


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NEUROBIOLOGY

Born Lab (and Haefner Lab)

TWO (EXP+THEORY) POSTDOCTORAL FELLOWSHIPS IN SYSTEMS NEUROSCIENCE
Perceptual decision-making in a probabilistic inference framework The laboratories of Rick Born in the Dept. of Neurobiology at Harvard Medical School, and Ralf Haefner in the Dept. of Brain & Cognitive Science at University of Rochester, are seeking applications for two NIH-funded postdoctoral fellowships to study the role of top-down connections in conveying learned priors within a theoretical framework of perception as probabilistic inference. Specific projects will address the neural bases of multi-tasking and confirmation bias. Experimental techniques include population recordings from area V1 with and without cortical feedback inactivated by cooling V2/3. 
Data analysis techniques include applying latent-state inference methods. Theoretical work will involve generating empirically testable predictions using sampling-based and variational techniques applied to probabilistic models.

The successful candidates will interact extensively with each other, both PIs and their labs.
Please visit the lab web sites (Born Lab & Haefner Lab) to obtain more information on current interests and electronic versions of recent research papers.
Preliminary results from a closely related project on learning can be found here: http://www.hms.harvard.edu/bss/neuro/bornlab/lab/papers/lange-etal-areadne-2018.pdf

The ideal candidate for the experimental position will have experience in one or more of the following areas: training nonhuman primates, extracellular electrophysiology, reversible inactivation of cortex, MATLAB programming. Candidates with a computational neuroscience background and an interest in visual processing will also be considered.
Candidates for the theoretical position should have strong quantitative and programming skills, ideally (but not necessarily) with experience in computational neuroscience and probabilistic modeling.

Salary will be commensurate with experience according to the current NIH scale.

Please send curriculum vitae, statement of research interests, up to three reprints, and a minimum of two letters of recommendation to either richard_born@hms.harvard.edu or rhaefne2@ur.rochester.edu.

Harvard Medical School and University of Rochester are Affirmative Action/Equal Opportunity Employers. Applications from minorities and women are especially encouraged.

 

 

Drugowitsch Lab at Harvard Medical School
We are looking for a highly creative and motivated postdoctoral fellow to work in the field of computational and systems neuroscience in the group of Jan Drugowitsch - Department of Neurobiology at Harvard Medical School. The group works on questions of decision-making and navigation under uncertainty, ranging from the level of neural populations to that of behavior. In the short term, the postdoctoral fellow is expected to design and analyze behavioral and neural models of decision-making that are gauged against data from human subjects, collected by the laboratory of Dr. Wyart at École Normale Supérieure, Paris. In the long term, close interaction and collaboration with other members of the department is anticipated.

Candidates should have a strong analytical background, such as in computational neuroscience, physics, mathematics, engineering, or related, and feature an interest in the role of computation in neural populations and in theoretical neuroscience in general. Experience or familiarity with related machine-learning fields is also desirable. Previous experience should include sufficient programming skills to run numerical simulations, Bayesian methods, and expertise in the analysis of dynamical systems.
The position starts in or after April 2018, and is funded for several years, with an initial one-year appointment and expectation of extension given satisfactory performance. Salary depends on experience and is at levels above the NIH scale. More info
HERE.
Candidates should send a single PDF file, consisting of a 1-page motivation letter, CV, and publication list to jan_drugowitsch@hms.harvard.edu. Furthermore, candidates should organize two letters of reference, to be sent to the same e-mail address. The position is open until filled (posted on this site: 2.22.18).

Gu Laboratory at Harvard Medical School
A postdoctoral position is available to study the coordinate development of nervous and vascular systems using mouse genetics, biochemistry, imaging, and in vitro assays. Applicants should be accomplished in biochemistry, molecular biology, cell biology. Experience in the biochemical and functional characterization of proteins in the signaling pathways would be especially desirable.
 Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
 Chenghua Gu, D.V.M., & Ph.D
Department of Neurobiology
Harvard Medical School
Email: chenghua_gu@hms.harvard.edu
HMS Dept. of Neurobiology Website: http://neuro.med.harvard.edu/

Kaeser Lab at Harvard Medical School
The Kaeser lab in the Department of Neurobiology at Harvard Medical School is seeking postdoctoral fellows to study architecture, functions and diversity of presynaptic neurotransmitter release sites. We are deeply invested into dissecting the molecular machines called active zones that mediate the release of fast neurotransmitters, for example glutamate, and of neuromodulators, for example dopamine. We further study how active zone composition is modulated by activity and how cell-type or synapse specific active zone architecture modulates circuit function. We use a variety of techniques (mouse genetics, protein biochemistry, electrophysiology, optogenetics, functional imaging, superresolution and electron microscopy) to study how active zones assemble and operate. Training in neuroscience and experience in any of these techniques is desirable, but not mandatory. We offer an excellent environment to use a multidisciplinary approach for addressing fundamental secretory mechanisms in a collaborative atmosphere.
Please email a cover letter, a curriculum vitae, and names & email addresses of three references to:
Dr. Pascal Kaeser
Department of Neurobiology
Harvard Medical School
220 Longwood Ave.
Armenise 305
Boston, MA 02115

Email: kaeser@hms.harvard.edu
Website: http://kaeser.hms.harvard.edu

Pecot Lab at Harvard Medical School
The Pecot Lab in the Department of Neurobiology at Harvard Medical School is seeking postdoctoral researchers interested in studying the molecular basis of precise neural connectivity. The goal of our research is to identify general molecular and cellular principles that underlie how neural networks are assembled. We address this at the level of identified cell types and synapses in the fly visual system. We are interested in the molecules that underlie how neurons distinguish each other and form synapses with appropriate partners, and in determining the gene regulatory networks that give rise to the expression of these genes in specific cell types. We employ a diverse experimental approach, involving molecular genetics, transcriptome profiling, genomics, confocal and superresolution microscopy, calcium imaging, and electron microscopy. Training in neuroscience or fly genetics is welcome but not necessary. We offer a supportive, collaborative and creative environment. 
Please email a cover letter, a curriculum vitae, and names & email addresses of three references to:
Matthew Y. Pecot, Ph.D.
Department of Neurobiology
Harvard Medical School
Armenise 203
Boston, MA 02115
Email:
matthew_pecot@hms.harvard.edu
Website: www.pecotlab.com


Weitz Laboratory at Harvard Medical School
A postdoctoral position is available for cryo-EM analysis of protein complexes comprising the core of the mammalian circadian clock, a molecular oscillator present in all or nearly all cells that drives daily rhythms of physiology and behavior. Applicants should be accomplished in biochemistry and structural biology. Expertise in cryo-EM structure determination would be especially desirable. We have made progress in single-particle analysis of native circadian clock complexes purified from mouse tissues, and we aim to obtain high-resolution structures.
Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Charles J. Weitz, M.D., Ph.D.
Department of Neurobiology
Harvard Medical School
Email: cweitz@hms.harvard.edu

Some recent papers:
1. Duong HA, Robles MS, Knutti K, Weitz CJ. A molecular mechanism for circadian clock negative feedback. Science 2011; 332: 1436-9.
2. Padmanabhan K, Robles MS, Westerling T, Weitz CJ. Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science 2012; 337: 599-602.
3. Kim JY, Kwak PB, Weitz CJ. Specificity in circadian clock feedback from targeted reconstitution of the NuRD co-repressor. Molecular Cell 2014; 56: 738-748.
4. Tamayo AG, Duong HA, Robles MS, Mann M, Weitz CJ. Histone mono-ubiquitination by Clock–Bmal1 complex marks Per1 and Per2 genes for circadian feedback. Nature Structural & Molecular Biology 2015; 22: 759-766.
5. Aryal RP, Kwak PB, Tamayo AG, Chiu PL, Walz T, Weitz CJ. Macromolecular assemblies of the mammalian circadian clock. Molecular Cell 2017 (in press).


Goodrich Laboratory at Harvard Medical School
The Goodrich lab is seeking a postdoctoral fellow to study the development of neural circuits in the auditory system. We use mouse genetics to understand how changes in the circuits of the inner ear affect an animal’s ability to detect and perceive sound. Projects employ a variety of techniques, including biochemical analysis of novel proteins, in vitro culturing of inner ear neurons, imaging of single cells during auditory circuit assembly, and gene expression profiling of wild-type and mutant cells. No experience with the auditory system is required, but a familiarity with neuroscience or mouse genetics is a plus. Individuals with expertise in cell biology, imaging, microarrays, or signal transduction are particularly encouraged to apply.

Please send a cover letter, CV, and three references to:

Dr. Lisa Goodrich

 

Dept of Neurobiology, Harvard Medical School
220 Longwood Avenue
Goldenson 442
Boston, MA 02115
Email: Lisa_Goodrich@hms.harvard.edu

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SYSTEMS BIOLOGY

 

Paulsson Lab - Research Specialist - Harvard Medical School (posted 9.11.18)
Job Description: The Paulsson lab in the Department of Systems Biology at Harvard Medical School is recruiting a Research Specialist to work in partnership with the PI (Johan Paulsson) to manage a wide range of challenging and exciting projects at the interface of bacterial physiology and biophysics. We are looking for a broadly trained bacterial geneticist excited about fundamental mechanisms as well as method development. The position involves three major activities: intellectual contributions on a wide range of projects related to bacterial genetics, physiology and evolution; managing a small team of technical staff to engineer proteins and circuits at the level of deep mutational scans and complex synthetic circuits; and serving as a scientific project manager for grant submissions and reports. The Research Specialist is expected to be a key intellectual partner and collaborator for many lab members, and will be recognized as an author on publications and patents whenever appropriate. 

Preferred Qualifications: 
A PhD in a biology-related field is required, with extensive and in-depth experiences in bacterial genetics and physiology, preferably E. coli but experience with other bacterial  species would also be valued. Scientific rigor and great attention to detail are essential, and creativity and an ability to see the bigger picture are a great plus. This is a high-energy and highly interactive position, where so excellent personal skills, including a sense of humor, are vital. SVery strong writing skills are also key. To apply, please submit a cover letter and CV to Johan_Paulsson_Office@hms.harvard.edu. Please note that this position is classified in the Harvard system as a Research Associate.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

 

3 month Teaching Postition with Michael Springer (posted 4.4.18)

 

Starting date: As soon as possible

Pay: You will be paid a stipend as a graduate student or post-doc as appropriate given your current position.

Job description: We have been working on converting our MATLAB bootcamp (Neurobiology 306qc) into a HarvardX course. The course is nearly complete, but before releasing the course we want to generate a series of adaptive questions and assignments that will help students taking the course learn more deeply and at their own pace.

Your role will be to draft short problems for introductory MATLAB programming assignments. Topics include arrays, images, file i/o, functions, loops, and simple data cleaning. In addition, you will assist me in the creating longer MATLAB-based projects for online learners, and work with HarvardX’s research team to ensure that the problems function properly once they are in the course.

The ideal candidate be able to work full time for one to three months, starting as soon as possible. Work from home or remote locations is permitted, with a weekly meeting in-person or via video chat. If desired, excellent performance may result in an offer of further work when the online course goes live, assisting students in the online discussion forums and troubleshooting broken problems.

Qualifications:
  * Programming in MATLAB (intermediate)
* Must be reliable and well-organized

Additional qualifications, preferred:
* Programming in Python (beginner)
* Basic HTML or XML
* Experience as a teacher, teaching fellow, or teaching assistant
* Having taken the Harvard MATLAB bootcamp

If you are interested contact Mike Springer, at michael_springer@hms.harvard.edu

 

 

Higgins Laboratory at Harvard Medical School
Research Area:  Mechanistic Mathematical Modeling of Human Disease Processes with Clinical Data

Description:  The Higgins Laboratory (Department of Systems Biology) has an opening for a postdoctoral fellow to study in vivo human blood cell population dynamics, characterizing rates of immunologic and hematologic processes and their fluctuations during times of health as well as when perturbed by diseases including infection, cancer, and diabetes, both acutely and chronically. 

Qualified applicants will have extensive knowledge of and interest in human pathophysiology, dynamical systems, numerical methods, and good software engineering practices.  For example, strong candidates would be able to compare and contrast the following:  finite elements and finite differences, lymphocyte and myelocyte, quicksort and bubble sort.  Applicants should have a Ph.D. and/or M.D. degree or be in the final year of their doctoral studies, and at least a strong undergraduate background in math, computer science, and engineering.  Interested individuals should apply by submitting an updated CV, complete contact information for three references, and a cover letter describing past research experience, research interests, and career goals.


Mootha Laboratory at Harvard Medical School
The Mootha laboratory (Department of Systems Biology) has a funded opportunity for a postdoctoral scientist in computational genetics.
The laboratory focuses on mitochondrial biology and disease and consists of a lively group of computational biologists, experimental biochemists, and physician-scientists. We are currently seeking a postdoctoral scientist to work at the interface of human genetics and systems biology, with the goal of analyzing very large scale human genome sequence datasets using network models of mitochondria derived from cellular and biochemical studies, to address questions spanning disease, epistasis, and evolution.
 Applicants should possess a Ph.D. and/or M.D. degree in computational biology, preferably with a proven track record in computational genetics and analysis of next-generation sequencing data. Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to vamsi@hms.harvard.edu.
 For additional information please visit our webpage: http://mootha.hms.harvard.edu/


Fontana Laboratory at Harvard Medical School
The Fontana Laboratory is seeking two outstanding post-docs to accomplish in collaboration with other groups a prototype end-to-end pipeline that extracts detailed mechanistic information about protein-protein interactions from databases and text, assembles such information into executable reference models for the purpose of understanding their dynamical behavior and assessing the current knowledge base in specific cell signaling systems. A can-do attitude, hacker soul, originality coupled to team spirit, fearlessness, and dedicated work ethic are necessary characteristics. Pay is commensurate to experience.
 Position 1: Computer science / AI / bioinformatics / databases
The ideal candidate combines an interest, and possibly expertise, in Artificial Intelligence (text extraction, natural language processing, reasoning) with bioinformatic skills. The individual will collaborate with other groups in excavating information about molecular interactions from extant databases and text; organizing such information for translation into a formal and executable format from which models of cellular signaling are constructed. The candidate should be capable of scripting in Python or Perl, be familiar with procedural and functional programming paradigms (e.g. Java or similar and OCaml or similar) and have database experience.
Position 2: Modeler / cellular signaling / cancer pathways
The ideal candidate is a computational biologist with experience in modeling dynamical systems. The individual is a skilled programmer (C, C++ or similar, experience with OCaml a plus) who will work with Kappa, a formal agent-based modeling language (https://github.com/jkrivine/KaSim) and associated tools. Ease with formal / mathematical thinking is required. A sound instinct for molecular biology coupled to a physics mindset is highly desirable. The position functions as a modeling keystone within an ambitious project seeking to build large dynamic “reference models" of cell signaling networks involved in RAS-related cancers. Models of such networks are assembled using mechanistic knowledge extracted from databases and texts in collaboration with outside groups providing pertinent expertise.

To apply, send CV and a covering letter to Walter Fontana: walter@hms.harvard.edu.


Megason Laboratory at Harvard Medical School
A postdoctoral research fellow position is available in the Megason lab in the Department of Systems Biology at Harvard Medical School in the areas of embryology, genetics, imaging, and systems biology. The Megason Lab has initiated a project to generate a Digital Fish which is a computer recreation of how the genome is executed to turn an egg into an embryo. We combine novel imaging technologies called in toto imaging to extract quantitative molecular and cellular data from living, developing zebrafish embryos for use in modeling. In toto imaging uses confocal and 2-photon microscopy to image and track every cell in developmental processes to reconstruct complete digital cell lineages. We also are developing a novel genetic approach called FlipTraps which generate endogenously expressed fluorescent fusion proteins and Cre condtional alleles. We combine these approaches to generate quantitative models of how systems of molecules program cells and systems of cells program tissues. Additionally, we are particularly interested in applicants with experience, expertise, and interest in home built 2-photon microscopy systems. For more information please contact Sean Megason (megason@hms.harvard.edu) or visit our website www.digitalfish.org.

A cover letter detailing your research motivations and a curriculum vitae should be sent by email to the above address together with the names of three referees with contact information.

Sean Megason, PhD
Department of Systems Biology
Harvard Medical School
200 Longwood Avenue, WAB 536
Boston, MA 02115


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HARVARD SCHOOL OF DENTAL MEDICINE 

YANG LAB

A post-doctoral position is available immediately in the Yang lab based in the Department of Developmental Biology at the Harvard School of Dental Medicine.

The laboratory of Dr. Yingzi Yang has a longstanding and intense interest in defining the functional mechanisms of Wnt, Hippo, and Hedgehog signaling pathways in development and disease pathogenesis including cancer. One of our recent projects is understanding metabolism and tumor microenvironment in liver hepatocyte carcinoma (HCC) progression. This study is being pursued through the generation and analyses of genetically engineered mice, in vitro studies with cell biology and biochemistry approaches as well as corroborative studies using human specimens. This work also involves cutting-edge imaging techniques and liver tumorigenesis in vitro and in vivo models. Protein chemistry and engineering is a plus. The position is funded by NCI.

The candidate should have a PhD degree in biomedical sciences with less than 3 years of postdoctoral experience and a proven record of scientific productivity. Basic skills in molecular, genetic and cell biology are required. Duties and responsibilities of the successful candidate will include:

• strong abilities to work independently and with self-initiative;

• abilities to vigorously pursue scientific projects, both conceptually and experimentally, with pro-active thinking and action;

• collaboration with other research staff, supervision and training of lab members;

• writing and editing of manuscripts, research presentations at departmental seminars and scientific meetings.

Salary will follow NIH and university guidelines.
To apply, please send a brief statement of research interests, CV and contact information of three references to:
Yingzi Yang, PhD
Yingzi_yang@hsdm.harvard.edu
(posted 6/7/18)

Posted: November 22, 2017:

A postdoctoral research fellow position is available in the laboratory of Dr. Andreia Ionescu at Harvard School of Dental Medicine in Boston. We are seeking Postdoctoral candidates who are independent, highly motivated and career-oriented to work on NIH-funded projects in the areas of cartilage development and disease (osteoarthritis). The successful candidate will be involved in identification of the gene signature of cartilage progenitor cells.

Potential candidates should have experience working with molecular biology, stem cells, tissue culture techniques, and mouse models. Expertise in DNA manipulations and generating stable cell lines using Lentiviral vectors and the CRISPR/Cas9 system is desirable. A strong background in molecular and cellular biology as well as Rna-seq and ChIP-seq analyses will receive higher priority. Prior experience with stem cell biology is a plus.

To apply, send your CV and email addresses of three references to:
Dr. Andreia Ionescu, PhD,
Dep. of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Ave, Boston, MA 02115. Tel: 617-432-5912
Email: Andreia_Ionescu@hms.harvard.edu

For more information, visit our website at:  http://hsdm.harvard.edu/ionescu-lab

 

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WYSS INSTITUTE

Postdoctoral Fellows Positions at the Wyss Institute for Biologically Inspired Engineering
The Wyss (pronounced "Veese") Institute for Biologically Inspired Engineering uses Nature's design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world.
 Working as an alliance among Harvard's Schools of Medicine, Engineering, and Arts & Sciences, and in partnership with Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Dana Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Tufts University, and Boston University, the Institute crosses disciplinary and institutional barriers to engage in high-risk research that leads to transformative technological breakthroughs.
 
Visit the Wyss Institute's website to find out positions available: http://wyss.harvard.edu/viewpage/191/postdoctoral-positions

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