Open Postdoc Positions

Postdoctoral Positions at HMS Quad-based Labs

The Dean's Postdoctoral Fellowship | Curriculum Fellows ProgramBiological Chemistry and Molecular Pharmacology | Biomedical Informatics | Cell Biology | Center for Bioethics | Genetics | Global Health and Social Medicine | Harvard Catalyst | Harvard Program in Therapeutic Science | Health Care Policy | ImmunologyMicrobiology | Neurobiology | Systems Biology | Harvard School of Dental Medicine | Wyss Institute

This page lists some of the postdoctoral positions currently available on the HMS Quadrangle. Many principal investigators do not advertise their postdoctoral positions with us, so if the PI you want to work with isn't listed here, please contact her/him directly. Please do not send your CV to the administrator of this page.
For non-Quad or external positions please see: postdoc.hms.harvard.edu/job-opportunities

Quad Departments: to have an opportunity listed on this page, send along a description of the postdoctoral position and contact information to us HERE. Please direct any questions to postdoc_office@hms.harvard.edu.

Postdoc openings at other Harvard affiliated institutions:
Beth Israel Deaconess Medical Center | Brigham & Women's Hospital | Children’s Hospital | Dana-Farber | Joslin | Mass General Hospital * | McLean Hospital* | T.H. Chan School of Public Health*
*Please note: some Harvard affiliates do not advertise individual postdoc positions with us, it may be best to identify a PI conducting work in your specific area of interest, and to email that PI directly with your CV and cover letter.


~FEATURED FELLOWSHIP OPPORTUNITIES~

Research Rigor and Reproducibility Curriculum Fellow | HMS
The Research Rigor and Reproducibility (R3) initiative at Harvard Medical School (HMS) in Boston, Massachusetts is seeking an innovative, collaborative science educator to serve as R3 Curriculum Fellow (CF). The R3 CF will develop teaching curricula, work with faculty to modernize biomedical research training, and support the development and administration of the HMS R3 program. The fellow will be a member the HMS Curriculum Fellows Program (CFP), a postdoctoral training program for biomedical scientists interested in a variety of education-focused careers. CFs work full-time with members of the HMS faculty and administration to develop, deploy, and evaluate evidence-based graduate training while receiving mentorship and career advising to support their development as educators.  

Advances in modern biomedical research require the continuous development of and support for a culture that advances research rigor and reproducibility (R3). HMS is committed to identifying, exploring, and supporting R3 principles relevant to our research community through cross-discipline conversations and collaborations. The HMS R3 Committee supports R3 through organizational development, training and educational programs, and resources and tools for our students, trainees, faculty, and staff. The R3 CF will be a critical contributor to those efforts. 

Based in the Office for Academic and Research Integrity and working closely with the Office of Research Operations and the Curriculum Fellows Program, the R3 Curriculum Fellow will provide support for the HMS R3 Working Group and Faculty Advisory Committee. The CF will play a key role in developing R3-related curriculum and in cataloguing, developing, implementing, and maintaining HMS resources related to research rigor and reproducibility. Some specific duties and responsibilities of the R3 Fellow will include:
1) Assisting the R3 committee and R3 Working Group in the planning, implementation, data collection, review, and presentation of an HMS community-wide R3 Preliminary Landscape Analysis
2) Working with HMS Graduate and Medical Education units, the Office for Postdoctoral Fellows, HMS faculty, and others to expand and develop R3-relevant curricula and training programs at HMS, and to make available some basic R3 course material as online training modules via the Harvard Training Portal
3) Assisting the R3 committee and R3 Working Group in the development, implementation, and maintenance of the HMS R3 website 

Qualifications: 
- An earned Ph.D. in a biomedical science
- The ability to interact with various R3 stakeholders including faculty at all levels, information technology professionals, and project managers
- Postdoctoral research or teaching experience (preferred)
- Demonstrated interest in the metascience of research and data integrity, data management
- Knowledge of the research data lifecycle in the academic laboratory environment 

 Job Skills and Competencies: 
- Strong interest in keeping up with emerging trends, best practices, and new knowledge in the fields of data management, the research data lifecycle, and information technology
- Ability to engage with faculty, administrators, other researchers, and lab managers to integrate their input and ensure R3 projects fully reflect their directives and priorities
- Strong organizational skills, communication skills (written, oral and presentation); a concern for accuracy, details, and quality
- Tolerance of ambiguity and uncertainty in a constantly evolving field
- Adaptability and ability to prioritize work and to be flexible in job tasks
- Highly self-motivated and directed 

The Curriculum Fellow’s appointment is renewable annually for a maximum of three years and is non-tenure-track. The fellowship is intended for early-career scientist-educators, therefore applications from candidates with more than 5 years of postdoctoral research or teaching experience are discouraged. Fellows are appointed as research associates, with possible promotion to the rank of Lecturer, contingent on experience and performance. The R3 Curriculum Fellow position is open for an immediate start. Applications will be reviewed as they are received until the final submission deadline of 9 AM Eastern Time on Friday, April 24th. The position will remain open until filled.   

To apply: Applicants should include a single PDF document containing:  
(1) a letter of application that addresses your interest in and qualifications for the position 
(2) a curriculum vitae 
(3) a teaching statement 
(4) the names and contact information of three professional references 

Email application materials to cfp@hms.harvard.edu, attention Dr. Bradley Coleman, Director of the HMS Curriculum Fellows Program.    

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law. 

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The Dean's Postdoctoral Fellowship

The Dean’s Postdoctoral Fellowship at Harvard Medical School is a two-year research fellowship established to nurture, advance, and retain a diverse scientific workforce that will continue to contribute to diversity through their ongoing academic and research scholarship.  The fellowship program prepares scientists from groups historically underrepresented in the basic and social sciences for careers in academia and other sectors. Fellows benefit from a highly innovative and creative research environment that emphasizes scientific rigor, collaboration, and the pursuit of excellence in science. 

BENEFITS
The two-year fellowship provides funding in the amount of $50,000/year, and DPF fellows are eligible for Harvard’s generous benefits package. They receive additional opportunities for career enhancement, mentorship, seminars, workshops, and conferences, along with a robust support network, through the Harvard Medical School Scholars in Translational and Academic Research (HMS STARs) program.

ELIGIBILITY

·         Have an MD, MD/PhD, PhD, ScD, or equivalent degree in the basic or social sciences.

·         Have United States citizenship or permanent resident status.

·         Come from a background that is historically underrepresented in the basic and social sciences.

·         Have no more than two years of postdoctoral experience.

ELIGIBLE DEPARTMENTS
Fellows conduct research with faculty within the basic and social science departments at Harvard Medical School. For a list of eligible departments, click here.

APPLICATION PROCESS
The application for the Dean’s Postdoctoral Fellowship is available on the DICP website at www.mfdp.med.harvard.edu/deanspostdoc
Applicants need to submit this form along with a cover letter, CV, and a statement that makes the connection between the mission of the Fellowship and their research interests and professional goals.

RECOMMENDATIONS
Three letters of recommendation are required, one of which must be from the applicant’s thesis advisor. For those who have held a postdoc position, the second letter must be from their postdoc advisor.

DEADLINE
Applications are currently accepted on a rolling basis, with the recommendation that they be submitted at least 4 months ahead of the candidate’s anticipated start date. 

SELECTION
Applications are reviewed by a committee comprised of Harvard Medical School faculty and administrators. Fel­lows are selected on the basis of their demonstrated aca­demic achievement, scholarly promise, commitment to research, potential to add to the diversity of the Harvard Medical School community, and the likelihood that the in­dividual may become an independent scientist and societal leader who, upon the completion of the fellowship, will continue to contribute to diversity through their ongoing academic and research scholarship.

Interested candidates are encouraged to contact Lyn Fulton-John, Program Manager, Dean’s Postdoctoral Fellowship Program at dicp_deanspostdoc@hms.harvard.edu or by phone at 617-432-9051 with any questions they may have.

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The Harvard Medical School Curriculum Fellows Program (CFP)

Curriculum Fellow in Translational and Biomedical Sciences
Institution: Harvard Medical School | Location: Boston, MA | Category: Faculty – Science | Type: Full Time
The Leder Human Biology (LHB) Program at Harvard Medical School (HMS) is seeking an innovative, collaborative early-career science educator to provide broad curricular and academic support to LHB, a translational medicine certification for HMS biomedical PhD students. The Curriculum Fellows Program is a postdoctoral service and training program focused on curriculum development, teaching, and educational programming in the biological and biomedical sciences at Harvard Medical School (HMS). Curriculum Fellows work closely with members of the HMS faculty and administration to develop, deploy, and evaluate evidence-based graduate training. Fellows also receive mentorship and career advising to support their development as educators and help them succeed in a variety of education-focused careers.
Responsibilities:
- Work closely with the faculty directors of the Leder Human Biology program at Harvard Medical School to organize, teach, and evaluate courses required for the translational medicine certification
- Serve as Associate Course Director in BCMP 234 (Cellular Metabolism and Human Disease), one of the required semester-length courses for the LHB Program. Manage and mentor the course’s Teaching Fellows and help lead critical reading sections
- Provide support and guidance for student-organized para-curricular activities associated with the Leder Human Biology program
- Catalyze and evaluate initiatives to improve biomedical education across Harvard Medical School, and make evidence-based recommendations to faculty and teaching staff on curricular design
- Support a short course on Case Studies in Human Biology
Qualifications:
- An earned doctorate in a field relevant to biology, biochemistry, or the biomedical sciences
- Experience teaching graduate or undergraduate science courses
- Advanced knowledge of or training in translational biomedical sciences (preferred)
- Postdoctoral research in a field relevant to the translational sciences (preferred)
Job Skills and Competencies:
- Ability to work collaboratively with multiple faculty with the purpose of organizing a semester-long course in cellular metabolism and human disease
- Experience applying evidence-based teaching methods and technological innovations to the classroom and working with faculty members to develop effective teaching strategies
- Strong organizational and management skills
- Commitment to the professional development and mentorship of PhD students in the Leder Human Biology program
The CF appointment is renewable annually for a maximum of three years and is non-tenure-track. The fellowship is intended for early-career scientist-educators, therefore applications from candidates with more than 5 years of postdoctoral research or teaching experience are discouraged. Fellows are appointed as research associates, with possible promotion to the rank of Lecturer, contingent on experience and performance. The LHB Curriculum Fellow position is open for an immediate start. Applications will be reviewed as they are received until the final submission deadline of 9 AM Eastern Time on Friday, September 4th. The position will remain open until filled.
To apply:
Applicants should email a single PDF document containing:
(1) a letter of application that addresses your interest in and qualifications for the position
(2) a curriculum vitae
(3) a teaching statement
(4) the names and contact information of three professional references
Email application materials to cfp@hms.harvard.edu, attention Dr. Bradley Coleman, Director of the HMS Curriculum Fellows Program.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.  (posted 8.5.20)

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~DEPARTMENTAL LISTINGS~

BIOLOGICAL CHEMISTRY AND MOLECULAR PHARMACOLOGY

The Lassar Lab

The Lassar lab at Harvard Medical School (in the Department of Biological Chemistry & Molecular Pharmacology) has an opening for a postdoctoral fellow to study the transcriptional regulatory network that controls both the formation and maintenance of articular cartilage.  Current efforts are to understand how extracellular signals promote the expression and regulate the activity of a newly identified articular cartilage transcription factor that is essential for articular cartilage formation.  The lab seeks to understand the gene regulatory network that controls synovial joint formation by use of novel genetically engineered mice, isolation of articular chondrocyte precursor populations, RNA-Seq, ATAC-Seq, and ChIP-Seq technologies.  Fundamental knowledge gained from these approaches will be leveraged to develop novel regenerative approaches to treat joint pathology in murine models of osteoarthritis.  

Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry, Genetics or a related field.  In addition, the applicant should be highly motivated, have an excellent working knowledge of molecular biology techniques and be able to work constructively with others.  Prior work with genetically engineered mice and/or regulation of gene expression would be a plus. Interested individuals should send a cover letter, curriculum vitae, and the names/e.mail addresses of three people who could provide letters of reference by email to Andrew_Lassar@hms.harvard.edu. (Posted 9.27.19)

Postdoctoral Research Fellow and Project Manager, Translational Metabolism Research
Job Description: The Sheu Lab at Brigham and Women’s Hospital and the Devlin Lab at Harvard Medical School are currently seeking a talented, driven, PhD-level scientist to lead these labs’ joint effort to develop a novel therapeutic for the treatment of type 2 diabetes mellitus (T2D) and obesity. Dr. Eric Sheu is an Assistant Professor of Surgery at Brigham and Women’s Hospital. The Sheu lab studies mechanisms of diabetes remission following bariatric surgery.  Dr. Sloan Devlin is an Assistant Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. The Devlin lab uses strategies from chemical biology to understand how small molecules produced by human gut bacteria affect human health and disease.
This position is a unique opportunity for a postdoctoral fellow to lead a research team and work at the intersection of academia and industry. This postdoc, along with the principle investigators, will develop a novel T2D therapeutic using in vitro and in vivo models of diabetes. This individual will both perform experiments in-house and will also plan and manage studies carried out at contract research organizations. The position will involve significant interactions with industry, venture capital, and private funding agencies. This position provides an excellent opportunity any person interested in drug discovery to jump-start his/her career in translational science.
Qualifications:

  • Innovative experimental biologist with significant previous basic science research experience who has a strong interest in accelerating scientific discoveries to the clinic.
  • Ph.D. and/or M.D. or graduating with a PhD by summer of 2019.
  • Background and expertise with mouse models of obesity and diabetes, including glycemic and insulin tolerance testing, are highly desired.
  • Experience in molecular / cell biology, specifically in relation to the study of metabolism, is preferred.
  • Strong history of publication in peer-reviewed journals.
  • Ability to work effectively with interdisciplinary teams.
  • Excellent oral and written communication skills.

Please send cover letter, C.V., and references to BOTH Eric Sheu, MD, PhD and Sloan Devlin, PhD. (Posted 5.22.19)

The Arthanari Lab
The Arthanari Lab at Department of BCMP, Harvard Medical School and Department of Cancer Biology, Dana Farber Cancer Institute is seeking a highly motivated postdoctoral candidate with expertise in transcriptional biology. Our laboratory works at the interface of structural biology, drug discovery and mechanistic biology, focusing on transcription factors and their interactions with co-activators and mediators (e.g. Nature 2016 25;530 (7591): 485-9; Nature 2008 452 (7187): 604-9). Research efforts will be focused on the intersection of cancer biology/genetics and immune-oncology. The candidate is expected to have a comprehensive understanding of signaling pathways, epigenetics and transcription regulation. Experience in technical skills including cell culture, somatic genetic analysis (e.g., CRISPr, si-, sh- RNA knockdown and rescue), protein biochemistry, assay design and development and biological applications to advance discovery are preferred. The individual should be independent and passionate about science and have an established record of creativity, ability to work in teams and strong publication record in peer-reviewed scientific journals.
Interested applicants should send a CV, and the names/phone numbers of three references by email to hari@hms.harvard.edu

Blacklow Laboratory at Harvard Medical School
The Blacklow Laboratory at Harvard Medical School (Department of Biological Chemistry and Molecular Pharmacology) has an opening for a Postdoctoral position. The laboratory currently investigates structure-function relationships in Notch signaling, its downstream targets, and its epigenetic regulators.
Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry, Structural Biology or a related field.
Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to jobs_blacklowlab@hms.harvard.edu.

The Brown Laboratory
Postdoctoral Fellow in Electron Cryomicroscopy (Full posting: https://brown.hms.harvard.edu/jobs/93)
Position Description: A postdoctoral position is available in the Brown lab at Harvard Medical School. The lab uses the latest developments in cryo-EM to understand biological processes at the molecular level (e.g. Nature 524, 493–496 and Science 346, 718–722). The project will involve investigating the structure and function of large macromolecular complexes involved in cellular transport. This includes all steps from construct design to structure determination. In the long term, we aim to use detailed molecular models to facilitate the development of new and better therapeutics.
Job requirements: Applicants should hold (or will be shortly awarded) a PhD degree and have experience in molecular biology and protein purification. Prior experience with single-particle cryo-EM or X-ray crystallography is considered a major advantage. Candidates should have strong communication skills and an established record of creativity through principal authorship in peer-reviewed publication(s). The successful candidate should be passionate about science, motivated, proactive, and able to work in a team. While each lab member has their own project, lab members are encouraged to work together to solve common problems. A separate position is available for an outstanding candidate with expertise in electron cryotomography (cryo-ET).
The position is initially for 2 years with a possibility of extension.
If you’re interested in joining the lab, please send your CV with a brief description of your current research as well as 2-3 contacts for references to Alan_Brown@hms.harvard.edu before the 8th August, 2017.

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BIOMEDICAL INFORMATICS

Patel Group - Postdoctoral Fellows (posted 4.5.19)

The Department of Biomedical Informatics (DBMI) at Harvard Medical School is seeking a Postdoctoral Fellow with experience in database management (SQL), scientific programing (Python, R) and cloud computing (AWS, Google Cloud Platform) and an interest -- but not necessarily experience -- in biomedical data science (or related field, such as population genetics, biostatistics, or epidemiology). You will work with investigators from the Patel Group and Arjun Manrai, faculty members at HMS DBMI and build tools and computer infrastructure to enhance use of large and disparate datasets from the domains of biology and population health to enable precision medicine. The goal of our efforts is to usher in a new age of precision medicine through combining lab, ancestry, demographic, environmental, and genetic data to enable accurately classify disease and health that accounts for the diversity of the human population.
Job listing on Department website: 
https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/patel-group-0
Email applications including curriculum vitae, summary statement of personal objectives, and the names and email addresses of 2-3 references to Chirag Patel (chirag_patel@hms.harvard.edu).

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Postdoctoral Positions in the Lab of Paul Avillach (posted 2.12.19; updated 11.15.19)

1) Phenotype extraction and biomedical ontologies
Summary
The Department of Biomedical Informatics (DBMI) at Harvard Medical School is looking for a Postdoctoral Fellow to help build cutting edge research platforms. The real value in biomedical research lies not in the scale of any single source of data, but in the ability to integrate and interrogate multiple, complementary datasets simultaneously. We are combining clinical and genomics data across different scales and resolutions to enable new perspectives for essential biomedical questions. The research focuses on the development of novel methods and techniques for the integration of multiple heterogeneous clinic cohorts, Electronic Health Records data and multiple types of genomics data to encompass biological observations.

Responsibilities
The Postdoctoral Fellow will be responsible for developing novel methodologies and applications to facilitate high-throughput phenotype extraction, harmonize content with biomedical ontologies and integrate clinical and molecular genomic data.
The diversity of subject matter will require a creative mind and a candidate capable of deploying imaginative strategies and who is dedicated to solving complex and challenging problems within an interdisciplinary environment.

Basic Requirements
Candidates must have a PhD degree (or MD/PhD) in biomedical informatics, bioinformatics, Computational Biology, computer science, or a related field. Curriculum in and/or experience with standardized ontologies, terminologies, metadata, and related technologies as well as experience in programming and software development will be necessary for this opportunity. The candidate interested in this position must be highly motivated, willing to learn and demonstrate initiative in assigned tasks. Excellent written and verbal communication skills are crucial.

Additional Requirements
Preferred requirements for this position include experience with the Unified Medical Language System (UMLS), statistics, data mining and machine learning. Experience with R, Python, and/or Perl is desirable.

Terms
The position is available immediately and can be renewed annually.

How to apply
Email applications including curriculum vitae, summary statement of personal objective and research interests, PDFs of the best two papers, and the names and email addresses of three references to paul_avillach@hms.harvard.edu

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2) Post-Doctoral Fellowship at Harvard-MIT Center for Regulatory Science | Harvard Program in Therapeutic Science
The Harvard Program in Therapeutic Science (HiTS) invites applications for a fellowship position at the Harvard-MIT Center for Regulatory Science. The fellow will work with a multidisciplinary team to develop and evaluate novel computational methods to support automated detection of drug-drug interactions in large and disparate healthcare datasets.
ABOUT THE FELLOWSHIP PROGRAM
The Harvard-MIT Center for Regulatory Science is a partnership between Harvard, MIT and the FDA, focused on building innovative approaches for the development and evaluation of medical products. Working across academia, industry, and government institutions, the Center promotes regulatory science through research and education programs, uniting stakeholders under a common mission: promoting optimal patient health outcomes through biomedical innovation and the availability of safe and effective diagnostics and treatments. The Regulatory Science Fellows Program draws individuals of diverse experiences who are passionate about using novel applications of data science to improve the use of therapeutics in patient populations.
For this position, the Fellow will work with faculty at Harvard in the Department of Biomedical Informatics https://dbmi.hms.harvard.edu. The fellow will be based in the Avillach Lab, an interdisciplinary research group focused on the development of cutting edge techniques for the integration of multiple heterogeneous biological and clinical cohorts with the overarching goal of supporting individualized data-driven healthcare.
PROJECT DETAILS
The application of  healthcare claims data and electronic health records for use in pharmacoepidemiological studies is booming. Drug–drug interactions can be identified by mining such databases, including adverse drug reactions (ADRs) resulting from the prescription of a combination of drugs (CADRs), considered a special class of drug-drug interactions. While many ADRs can be anticipated and hence avoided, CADRs are highly complex and challenging to identify and, as a consequence, have not been well studied. CADRs may represent as many as 30 % of unexpected ADRs and their elucidation is of particular interest to the FDA.

The fellowship project will develop new signal detection algorithms using data mining techniques in real-world healthcare data derived from claims and electronic healthcare records. The project will aim to identify potential pharmacovigilance signals concerning drug-drug interactions across multiple diseases and syndromes.
Research activities include, but are not limited to:
- Extract and analyze information from a nationwide claims database including 67 million subjects
- Extract and analyze information from healthcare records in an academic pediatric hospital including 1.8 million patients
- Develop and test methods to detect adverse drug reactions from billing codes, drug prescriptions and lab value results
- Disseminate findings through national and international conferences and in peer-reviewed scientific publications
Basic Qualifications
PhD in computer science, engineering or a related field; Expertise in SQL query language; Expertise in R or Python programing languages
Application Procedure and Requirements
Applications will be accepted until the position is filled. Please include the following when applying: Curriculum vitae; Cover letter and a 2-page description of relevant experience as a single PDF; DOI or PMCID of up to three relevant publications. Selected candidates will be asked to provide letters of reference.

Additional Position Description
Host Institution: Harvard Medical School | Appointing Department: Harvard Program in Therapeutic Science |Research Laboratory: Paul Avillach |Location: Boston, MA |Category: Scientist |Other responsibilities: no administrative or teaching obligations |Duration of fellowship: 2 years

Contact: Paul Avillach, MD, PhD, Department of Biomedical Informatics, 10 Shattuck Street, Boston, MA 02115

 

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Postdoctoral Positions in the Lab of Maha Farhat

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Postdoctoral Positions in the Lab of Peter Kharchenko  (posted 2.12.19)
Job Description
The Department of Biomedical Informatics (DBMI) at Harvard Medical School and the Kharchenko Lab is looking to recruit several postdoctoral fellows interested in pursuing one or more of the following topics in computational biology:

Single-Cell Genomics
The fellow will be charged with developing novel statistical approaches to the analysis of single-cell genomic data, mathematical modeling of cellular processes, as well as applications of such techniques to study healthy and diseased tissues. Strong background in statistics, modeling of stochastic processes and multicellular systems is desired.

Computational analysis of epigenetic mechanisms disrupted in cancer and other disease-disrupted tissues
The fellow will be responsible for developing and applying computational methods for integrative analysis of genome-wide epigenetic, transcriptional and proteomic data, aiming to identify specific factors and molecular mechanisms underlying misregulation of the epigenetic states in several types of human cancer. The ideal candidate should have a strong quantitative background, ample experience with analysis of sequencing assays, and strong interest in cancer biology.

Computational analysis of nucleosome organization
The fellow will be part of the central analysis group for the extensive 4D-nucleus consortium project funded by the NIH. The efforts will be focused on the development of analysis techniques for the next generation of experimental methods for measuring organization and dynamics of the eukaryotic nucleus that are being developed by the members of the consortia. Experience with analysis of Hi-C and relevant imaging data is strongly preferred.

All projects are being conducted in close cooperation with the expert bench-side laboratories, providing an excellent opportunity for collaborative research. Harvard Medical School and the Department of Biomedical Informatics also provides for a rich scientific environment, with a number of relevant seminar series, invited speakers, and many neighboring laboratories working on related projects.

PhD in Computational Biology, Statistics, Physics or other related discipline is required. A strong record of publications in the field is desired.

To apply – please send cover letter, curriculum vitae and contact information for at least two references to Dr. Peter Kharchenko at peter_kharchenko@hms.harvard.edu. Applications will be considered until the positions are filled. Please specify which project you are interested in.

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Kharchenko Lab: Postdoctoral Opportunities (posted 1.28.19)
Single-cell Transcriptomics, Epigenetics | Spatially-resolved Transcriptomics | Gene Regulation | Cancer Heterogeneity, Therapy Resistance, Immune Microenvironment | Tissue Organization

A group led by Peter Kharchenko at the Department of Biomedical Informatics of the Harvard Medical School is searching for postdoctoral fellows interested in developing and applying novel statistical, computational and experimental approaches to study challenges posed by cancer biology and development/maintenance of healthy tissues at a single-cell resolution. The research questions are being pursued in close cooperation with expert bench-side laboratories, providing an excellent opportunity for collaborative research. In particular, we are looking for researchers interested in joining our efforts on single-cell atlas of human brain, lung, kidney and other organs as part of the NIH funded BRAIN and HuBMAP consortia. Fellows interested in application of advanced image analysis techniques to study organization of biological tissues are encouraged to apply.

More info at
http://pklab.med.harvard.edu/

Areas of Interest: Single-Cell Analysis, Spatial Analysis, Statistics, Cancer, Tissue homeostasis

Candidate qualifications:
- Robust knowledge of statistical methods, and probabilistic modeling techniques
- Experience with quantitative analysis of modern biological assays
- We welcome experience in image analysis, graphical models, and advanced machine learning
- A strong interest in conducting collaborative research
- Track record of publications in peer-reviewed journals

How to apply: Please send cover letter, curriculum vitae and contact information for at least two
references to Peter Kharchenko at peter_kharchenko@hms.harvard.edu. Applications will be considered until the position is filled.

Employer: Department of Biomedical Informatics has been recently formed at the Harvard Medical School to lead development of computational and informatics techniques to address pertinent challenges in modern biological sciences and medicine. The Department’s faculty conduct research at the intersection of biomedicine and information sciences, including bioinformatics, functional genomics, translational medicine, and clinical knowledge management. The Department also hosts the Bioinformatics & Integrative Genomics PhD program (sponsored by NHGRI) and the Biomedical Informatics Masters program.

Harvard Medical School is an Equal Opportunity/Affirmative Action Employer.

Women and minorities are especially encouraged to apply.

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Gehlenborg Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/gehlenborg-lab

Kharchenko Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/kharchenko-lab

Patel Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/patel-group

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CELL BIOLOGY

Yuan Laboratory at Harvard Medical School
The Yuan laboratory at Harvard Medical School (Department of Cell Biology) has an immediate opening for a postdoctoral scientist. Our laboratory investigates the molecular mechanisms of cell death, including necroptosis and apoptosis, and their relevance for human diseases. This position is for a highly motivated individual with considerable experience in cell biology or related field. Experience in animal models of human diseases is desirable but not required.

Applicants should possess a Ph.D. and/or M.D. degree in molecular biology, cell biology, biochemistry, or neurobiology and a strong publication record. Interested individuals should send a curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to junying_yuan@hms.harvard.edu.

For additional information please visit our webpage: https://yuan.med.harvard.edu/


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CENTER FOR BIOETHICS

The Harvard Medical School Center for Bioethics invites applications for the Postdoctoral Research Scholars Program in Bioethics, for appointments commencing in summer/fall 2018.

This 1-2 year program prepares scholars with the knowledge and skills necessary to become leaders in the field of bioethics. Research scholars are fully integrated into the community of faculty and students at the Center for Bioethics, with access to the resources of Harvard Medical School and Harvard University. The program includes opportunities to collaborate with the scholars at the Hastings Center. We are particularly focused on attracting candidates with an interest in working on ethical and policy issues in regenerative and synthetic biology, genetic engineering, stem cell biology and embryology. Ideal candidates would be promising scientists in these areas with a background in bioethics or with a serious commitment to gaining expertise in the field
Research scholars will receive an annual stipend, benefits, and an allotment for academic expenses and travel.

The core experience includes:

  • Mentored research. Research scholars work closely with faculty mentors from across Harvard University to develop and conduct original research in the field of bioethics. A primary aim of the program is to prepare candidates with the training necessary to obtain competitive research funding and develop a successful academic career in bioethics.
  • Educational opportunities. The program seeks candidates with diverse backgrounds, experience, and knowledge. Each scholar works with faculty creating a personalized educational program that will delve into special areas of interest, as well as developing broad expertise in the field of bioethics. Research scholars have access to all the Center's courses and seminars, and may be able to audit relevant courses across Harvard University with faculty permission.
  • Community life. Postdoctoral research scholars will be fully engaged with the activities of the Center and the Harvard-affiliated teaching hospitals. Scholars will organize and conduct conferences and seminars, they will assist in teaching courses in their areas of interest, and will have opportunities to participate on hospital clinical ethics committees and institutional review boards.

In short, the Postdoctoral Research Scholars Program provides the greatest possible access to all that Harvard University has to offer.

Application Requirements:
Applications are invited from those who have or will have completed a doctoral degree (MD, JD, PhD or equivalent) by July 1, 2018. Doctorates may be in any relevant field, including but not limited to public health, psychology, economics, philosophy, sociology, or anthropology.
The deadline for summer/fall 2018 is March 30, 2018. Applications may be considered throughout the year under special circumstances.
Visit the website for application requirements: 
http://bioethics.hms.harvard.edu/postdoctoral-program


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GENETICS

Yankner Laboratory at Harvard Medical School

Postdoctoral positions available to study gene regulation, epigenetics and the molecular biology of aging and neurodegenerative diseases.  Projects focus on iPS cells, C. elegans, animal models and the biology of genes involved in aging and Alzheimer's disease. For reference see:   Nature. 2019;574(7778):359-64. Epub 2019/10/18, Cell Reports 2019 doi.org/10.1016/j.celrep.2019.01.023, Nature 507:448, 2014. Experience in molecular biology is required.

Send CV, a brief description of research experience and names of 3 references to: Dr. Bruce Yankner by email to marianna_liang@hms.harvard.edu

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GLOBAL HEALTH AND SOCIAL MEDICINE

Postdoctoral Fellowship in Multidrug-Resistant Tuberculosis Epidemiology
Start date: flexible | Location: Boston, MA | Duration: 2 years | Salary: consistent with NIH guidelines

Project Description
Applications from PhD or other doctoral-level degree holders are invited for a full-time project focused on improving the quality of evidence generated from observational treatment cohorts of multidrug-resistant (MDR) tuberculosis (TB). The position will be based in the Department of Global Health and Social Medicine (DGHSM) at Harvard Medical School, which conducts research to improve the practice of medicine, the delivery of treatment, and the development of health care policies locally and worldwide. Researchers at DGHSM have a long history of conducting research on tuberculosis, HIV, and other conditions. The selected candidate will join a team of epidemiologists and clinicians aiming to improve access to high-quality evidence-based care for MDR-TB around the world.
The postdoctoral fellow will work with us on the endTB observational study. Comprised of over 2,600 patients in 17 countries, this is the largest multi-country study of patients receiving MDR-TB treatment with the newer drugs, bedaquiline and delamanid. The postdoctoral fellow will apply advanced epidemiologic methods (e.g., marginal structural models, g-estimation) to longitudinal data to answer pressing outstanding questions related to the safety and effectiveness of different MDR-TB regimens. Under this NIH-funded initiative, the postdoctoral fellow will also contribute to the implementation of a prospective cohort study of patients receiving a shortened, all-oral MDR-TB regimen in one of five countries.
The successful applicant will be expected to participate as lead author on publications arising from this work and to communicate findings in oral presentations at national and international conferences. We are seeking candidates willing to commit to at least two years of work on this project.

Qualifications and Skills

  • Doctoral degree holders (or 2020 degree candidates) in Epidemiology, Biostatistics or related field.
  • Experience applying advanced epi methods, including: marginal structural models, g-formula and simulation studies.
  • Advanced programming skills in a statistical package such as SAS, Stata, or R.
  • Strong writing skills.
  • Ability to work collaboratively.
  • Interested in global health.

Application Instructions
Email the following items in one PDF with the surname as the first word of the PDF file: (1) cover letter stating long-term career aims, interest in the project, and suitability for the position, specifically referring to the criteria listed above; (2) curriculum vitae; (3) two or three relevant publications or manuscripts; and (4) contact information for three to five potential references. Applications should be emailed to: rebecca_grow@hms.harvard.edu

See this website for information about our department: https://ghsm.hms.harvard.edu/.

Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Applications from women and underrepresented minorities are strongly encouraged.  
(posted 7.10.20)

 

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HARVARD CATALYST

No positions currently listed.

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HARVARD PROGRAM IN THERAPEUTIC SCIENCE (HiTS)

Postdoctoral Fellowship for Geographic Information Systems (GIS) to Pathology | HiTS | HMS
Description: The objective of this project is to apply methods developed for the analysis of geographic and ecological features in GIS (Geographic Information Systems) to the understanding of human cancers. This will involve applying geospatial analytics, spatial and spatiotemporal statistics, environmental image processing, and ecosystem modeling techniques to human tumor images collected using very recently developed methods. The study aims to characterize patterns, relationships, and interactions among tumor cells, immune cells, and healthy cells based on these landmarks before, during, and after exposure of patients to therapeutic drugs.The position involves a joint appointment between the Harvard University Center for Geographic Analysis (CGA) and the Harvard Medical School Laboratory of Systems Pharmacology (LSP). The candidate will have space assigned at both the CGA and LSP and will attend group meetings and similar activities at both research centers. The appointment is for one year with the possibility of renewal based on satisfactory performance and continued availability of funding. This position has no teaching or administrative duties.

Qualifications: The successful candidate will have an MD and/or PhD and relevant experience in cancer immunology and/or breast or ovarian cancer research, geographic information science, remote sensing, or a related field. Interest in biological imaging is required. Prior experience working with mouse or human tissues and mastery of basic molecular biology techniques and cell culture are required.  Proficiency in fluorescence microscopy and/or single cell methods such as flow cytometry/CyTOF are also highly desirable.  The candidate should have an interest in acquiring skills in image processing and analysis and use of computational pipelines to produce and analyze single-cell data. A general understanding of Matlab/Python and prior experience in working with mouse or human tissues, including familiarity with tissue processing and analysis as well as basic knowledge of standard IHC is preferred. Excellent written and spoken English are required.

To apply, send a curriculum vitae, statement of research interests, and names and contact information for three references to Laura Maliszewski (laura_maliszewski@hms.harvard.edu). Research papers (up to three) are welcome but optional. Review of applications will begin immediately and end when the position is filled. Incomplete applications will not be reviewed. More information HERE. (Posted 8.30.19)

Postdoctoral Fellowship for Innovative Single-Cell Discovery Platform for Women’s Cancers | HiTS | HMS
Description: The Harvard Medical School (HMS) Laboratory of Systems Pharmacology (LSP) and Women’s Cancer Program at Dana-Farber Cancer Institute (DFCI) seeks an outstanding postdoctoral fellow who will use innovative single-cell methods to study mechanisms of immunotherapy response and resistance in patient tumors.  The fellow will be based in the laboratories of Dr. Peter Sorger at HMS and Dr. Beth Mittendorf at DFCI, where he/she will routinely interact with physicians, basic scientists and computational biologists to conduct high impact translational research.  The fellow’s research efforts will directly inform the design of novel clinical trials of immunotherapy for breast and ovarian cancer. The fellow will lead efforts to apply single cell genomics and imaging, including a new tissue-based, multiplexed immunofluorescence assay (tCyCIF: www.cycif.org) to study the tumor microenvironment in breast and ovarian tumors.  The high-dimensional single cell data will be used to identify novel cell types, functional states and drug targets. This position has no teaching or administrative duties.

Qualifications: The successful candidate will have an MD and/or PhD and relevant experience in cancer immunology and/or breast or ovarian cancer research.  Prior experience working with mouse or human tissues and mastery of basic molecular biology techniques and cell culture are required.  Proficiency in fluorescence microscopy and/or single cell methods such as flow cytometry/CyTOF are also highly desirable.  The candidate should have an interest in acquiring skills in image processing and analysis and use of computational pipelines to produce and analyze single-cell data.   A general understanding of Matlab/Python and prior experience in working with mouse or human tissues, including familiarity with tissue processing and analysis as well as basic knowledge of standard IHC is preferred.  Excellent written and spoken English are required.

To apply, send a curriculum vitae, statement of research interests, and names and contact information for three references to Laura Maliszewski (laura_maliszewski@hms.harvard.edu). Research papers (up to three) are welcome but optional. Review of applications will begin immediately and end when the position is filled. Incomplete applications will not be reviewed. More information HERE. (Posted 8.30.19)

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HEALTH CARE POLICY

No positions currently listed.

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IMMUNOLOGY

No positions currently listed.

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MICROBIOLOGY

Research Scientist, Molecular Virologist | Department of Microbiology | HMS
The Yang Group is currently recruiting a molecular virologist to work with a team of medicinal chemists, biochemists, and structural biologists in developing novel small molecule antivirals.  Preference will be given to individuals with prior experience with flaviviruses, but applicants with experience in any area of positive-strand RNA virology are encouraged to apply.  Most important is that you thrive working in a collaborative and fast-paced environment and that you are willing to learn and evolve as a scientist.  This is a great research scientist level position if you aren’t sure or if you are sitting on the academia versus industry fence, because you can learn skills relevant to industry while still training in an academic environment (i.e. answering questions is more important than making products).
Qualifications: A Ph.D. in molecular virology, including prior work with flaviviruses and/or hepatitis B virus is preferable.  Must be proficient in molecular biology techniques required for performing reverse genetics experiments to generate and characterize recombinant viruses.  Experience in analyzing viral gene expression and viral genome replication. Ability to independently design experiments to address mechanistic questions.  Excellent quantitative and communication skills and an ability to collaborate are essential.
Interested candidates should email Priscilla_Yang@hms.harvard.edu and include a cover letter, CV, statement of professional interests, and contact information for three letters of reference. Applicants may also send the material to Dr. Priscilla Yang, Department. of Microbiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA  02115. (Posted 6.14.19)

Abraham Laboratory at Harvard Medical School
The Abraham laboratory in the Department of Microbiology at Harvard Medical School is seeking a highly motivated postdoctoral candidate with expertise in virology, molecular biology, and genome editing (CRISPR/Cas9). Our laboratory uses a wide-array of approaches to study how emerging pathogens interact with cells and immune systems of their hosts. The project will involve performing genetic screens to probe host-pathogen interactions. Strong candidates would have extensive experience with mammalian tissue culture and viral infectivity assays. Publications from our laboratory include: Mahmutovic S et al. Cell Host & Microbe 2015, and Clark LE et al. Nature Communications 2018.
Interested applicants should send a CV, including the names/email addresses of 2-3 references, to abraham@crystal.harvard.edu  (11.26.18)

Gehrke Laboratory at Harvard Medical School
The Gehrke laboratory is looking for a U.S. citizen postdoc to join a team that is studying neurotropic virus infections using 2D and 3D tissue models.  Applicants must have Ph.D. or M.D. degree with a background in virology and familiarity with molecular techniques.  The work will involve BSL3 pathogens. Available immediately. Please send inquiries to lee_gehrke@hms.harvard.edu. (6.2.17)

Nibert Lab
August 20, 2018 - Postdoc Position available immediately
Available position: Postdoctoral research associate
Location: Nibert lab, Department of Microbiology, HMS (NRB-939, 77 Ave Louis Pasteur)

Project: Molecular biology of Trichomonas vaginalis viruses, including genomic characterizations, dissection of packaging/replication/translation signals, and structure-function studies of virus particles and proteins
Job Responsibilities include: Working collaboratively to design experiments, perform experiments, analyze data, present data to academic colleagues, prepare manuscripts.

Please email a CV, cover letter, and names of at least two references to:
Max Nibert, Professor of Microbiology
mnibert@hms.harvard.edu


Yang Laboratory at Harvard Medical School
The Yang Lab has two immediate openings for postdoctoral fellows to play a vital role in the discovery and optimization of small molecule antivirals. Must have established expertise in protein expression (microbial, insect, and mammalian cells) and purification as well as with a variety of biophysical and biochemical methods for characterizing protein-small molecule interactions. Experience with high-throughput screening and/or molecular virology techniques is desired but may be substituted with a willingness and aptitude to learn. Must be willing to work with viral pathogens in a BSL2+ lab.

You will be working within a multidisciplinary group of structural biologists, medicinal chemists, biochemists, and virologists. This position requires excellent communication and organizational skills, and a willingness to help train and mentor more junior members on the research team. This is an excellent opportunity for a post-doctoral fellow to acquire experience relevant to future employment in industry while still operating within an academic environment. This position is funded by an NIH grant through 2018. Applicants are expected to make a 3 year commitment.

Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Priscilla L. Yang., Ph.D.
Department of Microbiology and Immunobiology
Harvard Medical School
Email: Priscilla_yang@hms.harvard.edu


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NEUROBIOLOGY

Regehr LabPostdoctoral Positions (posted 7.10.20)
The Regehr lab is seeking postdoctoral fellows to work in an interactive lab environment in which the candidate will use multiple cutting edge techniques to address diverse questions. Areas of investigation include: the molecular and functional characterization of synaptic transmission, the behavioral significance of short-term synaptic plasticity, characterization of cerebellar circuitry, and the role of the cerebellum in motor and social behaviors. Techniques used include: slice electrophysiology, calcium measurements, caged neurotransmitters, AAV manipulation, optogenetics, mouse genetics, immunofluorescence, FISH, single unit electrophysiology in awake behaving animals, behavioral analysis (including many social behaviors, gait analysis, Motion Seq, VOR and conditioned eyeblink), serial electron reconstructions (in collaboration with the Lee lab), single cell molecular characterization of neurons in the cerebellum (in collaboration with the Makosco lab), and in vivo 2-photon functional imaging (in collaboration with the Harvey lab). Multiple positions are available. The ideal candidate should be creative, able to both lead their own independent project, and able to work with others on collaborative projects in a highly interactive environment.
Please email a cover letter, a curriculum vitae, and names & email addresses of three references to:
Wade G. Regehr
Department of Neurobiology
Harvard Medical School
Goldenson 307
Boston, MA 02115
Email: wade_regehr@hms.harvad.edu

Website: https://regehrmedharvard.wordpress.com/
(posted 7.10.20)

 

 

Harwell Lab - Postdoctoral position to study the cellular and molecular mechanisms of neural circuit assembly.
The Harwell lab in the Department of Neurobiology at Harvard Medical School is seeking postdoctoral fellows to study the development of neural circuits. We are primarily focused on understanding the cellular and molecular mechanisms that govern the production and assembly of neural circuits in the basal forebrain. We employ a diverse array of tools and techniques including mouse genetics, next generation sequencing technologies such as ChIP-seq and single-cell RNA-seq, optogenetics and electrophysiology, to understand the intrinsic molecular programs that specify neural cell identity and orchestrate assembly of neural circuits.
Ideal candidates will be creative, highly motivated individuals with excellent communication and interpersonal skills, with a strong background in cellular and molecular neurobiology. Desirable skills include whole cell patch-clamp electrophysiology and computer programming experience, but are not required. We offer a highly supportive and collaborative environment for addressing fundamental questions in developmental neurobiology. Prospective candidates should send a cover letter, C.V. and contact information for 3 referees to: Corey Harwell, Assistant Professor of Neurobiology, corey_harwell@hms.harvard.edu. Website: www.harwelllab.hms.harvard.edu (posted 3.29.19)

 

 

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Born Lab (and Haefner Lab)  (posted 3.12.19)
TWO (EXP+THEORY) POSTDOCTORAL FELLOWSHIPS IN SYSTEMS NEUROSCIENCE
Perceptual decision-making in a probabilistic inference framework
The laboratories of Rick Born in the Dept. of Neurobiology at Harvard Medical School, and Ralf Haefner in the Dept. of Brain & Cognitive Science at University of Rochester, are seeking applications for two NIH-funded postdoctoral fellowships to study the role of top-down connections in conveying learned priors within a theoretical framework of perception as probabilistic inference. Specific projects will address the neural bases of multi-tasking and confirmation bias. Experimental techniques include population recordings from area V1 with and without cortical feedback inactivated by cooling V2/3. Data analysis techniques include applying latent-state inference methods. Theoretical work will involve generating empirically testable predictions using sampling-based and variational techniques applied to probabilistic models.
Link to full posting

The successful candidates will interact extensively with each other, both PIs and their labs. Please visit the lab web sites (Born Lab & Haefner Lab) to obtain more information on current interests and electronic versions of recent research papers. Preliminary results from a closely related project on learning can be found here.
The ideal candidate for the experimental position will have experience in one or more of the following areas: training nonhuman primates, extracellular electrophysiology, reversible inactivation of cortex, MATLAB programming. Candidates with a computational neuroscience background and an interest in visual processing will also be considered.

Candidates for the theoretical position should have strong quantitative and programming skills, ideally (but not necessarily) with experience in computational neuroscience and probabilistic modeling.

Salary will be commensurate with experience according to the current NIH scale. Please send curriculum vitae, statement of research interests, up to three reprints, and a minimum of two letters of recommendation to either richard_born@hms.harvard.edu or rhaefne2@ur.rochester.edu.

Harvard Medical School and University of Rochester are Affirmative Action/Equal Opportunity Employers. Applications from minorities and women are especially encouraged.

 

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Drugowitsch Lab at Harvard Medical School
We are looking for a highly creative and motivated postdoctoral fellow to work in the field of computational and systems neuroscience in the group of Jan Drugowitsch - Department of Neurobiology at Harvard Medical School. The group works on questions of decision-making and navigation under uncertainty, ranging from the level of neural populations to that of behavior. In the short term, the postdoctoral fellow is expected to design and analyze behavioral and neural models of decision-making that are gauged against data from human subjects, collected by the laboratory of Dr. Wyart at École Normale Supérieure, Paris. In the long term, close interaction and collaboration with other members of the department is anticipated.

Candidates should have a strong analytical background, such as in computational neuroscience, physics, mathematics, engineering, or related, and feature an interest in the role of computation in neural populations and in theoretical neuroscience in general. Experience or familiarity with related machine-learning fields is also desirable. Previous experience should include sufficient programming skills to run numerical simulations, Bayesian methods, and expertise in the analysis of dynamical systems.
The position starts in or after April 2018, and is funded for several years, with an initial one-year appointment and expectation of extension given satisfactory performance. Salary depends on experience and is at levels above the NIH scale. More info
HERE.
Candidates should send a single PDF file, consisting of a 1-page motivation letter, CV, and publication list to jan_drugowitsch@hms.harvard.edu. Furthermore, candidates should organize two letters of reference, to be sent to the same e-mail address. The position is open until filled (posted on this site: 2.22.18).

Gu Laboratory at Harvard Medical School
A postdoctoral position is available to study the coordinate development of nervous and vascular systems using mouse genetics, biochemistry, imaging, and in vitro assays. Applicants should be accomplished in biochemistry, molecular biology, cell biology. Experience in the biochemical and functional characterization of proteins in the signaling pathways would be especially desirable.
 Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
 Chenghua Gu, D.V.M., & Ph.D
Department of Neurobiology
Harvard Medical School
Email: chenghua_gu@hms.harvard.edu
HMS Dept. of Neurobiology Website: http://neuro.med.harvard.edu/

Kaeser Lab at Harvard Medical School
The Kaeser lab in the Department of Neurobiology at Harvard Medical School is seeking postdoctoral fellows to study architecture, functions and diversity of presynaptic neurotransmitter release sites. We are deeply invested into dissecting the molecular machines called active zones that mediate the release of fast neurotransmitters, for example glutamate, and of neuromodulators, for example dopamine. We further study how active zone composition is modulated by activity and how cell-type or synapse specific active zone architecture modulates circuit function. We use a variety of techniques (mouse genetics, protein biochemistry, electrophysiology, optogenetics, functional imaging, superresolution and electron microscopy) to study how active zones assemble and operate. Training in neuroscience and experience in any of these techniques is desirable, but not mandatory. We offer an excellent environment to use a multidisciplinary approach for addressing fundamental secretory mechanisms in a collaborative atmosphere.
Please email a cover letter, a curriculum vitae, and names & email addresses of three references to:
Dr. Pascal Kaeser
Department of Neurobiology
Harvard Medical School
220 Longwood Ave.
Armenise 305
Boston, MA 02115

Email: kaeser@hms.harvard.edu
Website: http://kaeser.hms.harvard.edu

Pecot Lab at Harvard Medical School
The Pecot Lab in the Department of Neurobiology at Harvard Medical School is seeking postdoctoral researchers interested in studying the molecular basis of precise neural connectivity. The goal of our research is to identify general molecular and cellular principles that underlie how neural networks are assembled. We address this at the level of identified cell types and synapses in the fly visual system. We are interested in the molecules that underlie how neurons distinguish each other and form synapses with appropriate partners, and in determining the gene regulatory networks that give rise to the expression of these genes in specific cell types. We employ a diverse experimental approach, involving molecular genetics, transcriptome profiling, genomics, confocal and superresolution microscopy, calcium imaging, and electron microscopy. Training in neuroscience or fly genetics is welcome but not necessary. We offer a supportive, collaborative and creative environment. 
Please email a cover letter, a curriculum vitae, and names & email addresses of three references to:
Matthew Y. Pecot, Ph.D.
Department of Neurobiology
Harvard Medical School
Armenise 203
Boston, MA 02115
Email:
matthew_pecot@hms.harvard.edu
Website: www.pecotlab.com


Weitz Laboratory at Harvard Medical School
A postdoctoral position is available for cryo-EM analysis of protein complexes comprising the core of the mammalian circadian clock, a molecular oscillator present in all or nearly all cells that drives daily rhythms of physiology and behavior. Applicants should be accomplished in biochemistry and structural biology. Expertise in cryo-EM structure determination would be especially desirable. We have made progress in single-particle analysis of native circadian clock complexes purified from mouse tissues, and we aim to obtain high-resolution structures.
Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Charles J. Weitz, M.D., Ph.D.
Department of Neurobiology
Harvard Medical School
Email: cweitz@hms.harvard.edu

Some recent papers:
1. Duong HA, Robles MS, Knutti K, Weitz CJ. A molecular mechanism for circadian clock negative feedback. Science 2011; 332: 1436-9.
2. Padmanabhan K, Robles MS, Westerling T, Weitz CJ. Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science 2012; 337: 599-602.
3. Kim JY, Kwak PB, Weitz CJ. Specificity in circadian clock feedback from targeted reconstitution of the NuRD co-repressor. Molecular Cell 2014; 56: 738-748.
4. Tamayo AG, Duong HA, Robles MS, Mann M, Weitz CJ. Histone mono-ubiquitination by Clock–Bmal1 complex marks Per1 and Per2 genes for circadian feedback. Nature Structural & Molecular Biology 2015; 22: 759-766.
5. Aryal RP, Kwak PB, Tamayo AG, Chiu PL, Walz T, Weitz CJ. Macromolecular assemblies of the mammalian circadian clock. Molecular Cell 2017 (in press).


Goodrich Laboratory at Harvard Medical School
The Goodrich lab is seeking a postdoctoral fellow to study the development of neural circuits in the auditory system. We use mouse genetics to understand how changes in the circuits of the inner ear affect an animal’s ability to detect and perceive sound. Projects employ a variety of techniques, including biochemical analysis of novel proteins, in vitro culturing of inner ear neurons, imaging of single cells during auditory circuit assembly, and gene expression profiling of wild-type and mutant cells. No experience with the auditory system is required, but a familiarity with neuroscience or mouse genetics is a plus. Individuals with expertise in cell biology, imaging, microarrays, or signal transduction are particularly encouraged to apply.

Please send a cover letter, CV, and three references to:
Dr. Lisa Goodrich

Dept of Neurobiology, Harvard Medical School
220 Longwood Avenue
Goldenson 442
Boston, MA 02115
Email: Lisa_Goodrich@hms.harvard.edu

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SYSTEMS BIOLOGY

Mootha Laboratory at Harvard Medical School
The Mootha laboratory (Department of Systems Biology) has a funded opportunity for a postdoctoral scientist in computational genetics.
The laboratory focuses on mitochondrial biology and disease and consists of a lively group of computational biologists, experimental biochemists, and physician-scientists. We are currently seeking a postdoctoral scientist to work at the interface of human genetics and systems biology, with the goal of analyzing very large scale human genome sequence datasets using network models of mitochondria derived from cellular and biochemical studies, to address questions spanning disease, epistasis, and evolution.
 Applicants should possess a Ph.D. and/or M.D. degree in computational biology, preferably with a proven track record in computational genetics and analysis of next-generation sequencing data. Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to vamsi@hms.harvard.edu.
 For additional information please visit our webpage: http://mootha.hms.harvard.edu/


Megason Laboratory at Harvard Medical School
A postdoctoral research fellow position is available in the Megason lab in the Department of Systems Biology at Harvard Medical School in the areas of embryology, genetics, imaging, and systems biology. The Megason Lab has initiated a project to generate a Digital Fish which is a computer recreation of how the genome is executed to turn an egg into an embryo. We combine novel imaging technologies called in toto imaging to extract quantitative molecular and cellular data from living, developing zebrafish embryos for use in modeling. In toto imaging uses confocal and 2-photon microscopy to image and track every cell in developmental processes to reconstruct complete digital cell lineages. We also are developing a novel genetic approach called FlipTraps which generate endogenously expressed fluorescent fusion proteins and Cre condtional alleles. We combine these approaches to generate quantitative models of how systems of molecules program cells and systems of cells program tissues. Additionally, we are particularly interested in applicants with experience, expertise, and interest in home built 2-photon microscopy systems. For more information please contact Sean Megason (megason@hms.harvard.edu) or visit our website www.digitalfish.org.

A cover letter detailing your research motivations and a curriculum vitae should be sent by email to the above address together with the names of three referees with contact information.

Sean Megason, PhD
Department of Systems Biology
Harvard Medical School
200 Longwood Avenue, WAB 536
Boston, MA 02115


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HARVARD SCHOOL OF DENTAL MEDICINE 

Two Postdoctoral Positions | Harvard Medical School/Harvard School of Dental Medicine | Drs. Baron and Gori joint Laboratory (Baron-Gori lab)
GENERAL SUMMARY: Two Postdoctoral positions are available in the joint laboratory of Dr. Baron and Dr. Gori, Division of Bone and Mineral Research, Department of Medicine, Harvard Medical School/ Harvard School of Dental Medicine. The longstanding interest of our laboratory is to understand the molecular, cellular and genetic basis of bone growth and remodeling and the regulation of skeletal homeostasis in health and disease in humans, using animal models. The focus of one of these positions is to study the biology of the periosteal surface. In particular, our objective is to identify the role of Sfrp4, a Wnt signaling inhibitor we have shown to be implicated in Pyle Disease, in the expansion, differentiation and/or function of periosteal stem and osteoprogenitor cells. The focus of the other position is to examine novel signaling mechanisms by which PTH regulates Wnt signaling, increases bone formation rate and represses bone marrow adipose tissue and its role in the anabolic action of PTH/PTHrP in bone. A separate aspect of this work is to understand the role of osteocyte biology in the responses to PTH/PTHrP. Our laboratory aims for excellence in research and makes all efforts to publishing its work in the top tier scientific and medical journals. Training of young scientists is also a key aspect of our laboratory, with a very successful history.

The Baron/Gori laboratory is currently funded by three NIH institutes: NIDCR (Gori), NIDDK and NIAMS (Baron) as well as by other sources.

EDUCATION AND EXPERIENCE REQUIRED: The applicants must have a PhD degree. Combined MD/PhD or DDS-DMD/PhD degrees are a plus. We seek highly motivated young scientists who can work independently with strong written and oral communication skills. These projects involve the use of genetically engineered mice, cell and molecular biology and bioinformatic techniques as well as culture of primary cells and cell lines. Commensurate with experience, first author publication(s) in top-tier bone and/or cell and molecular biology journals, expertise in signal transduction analysis, FACS analysis and/or large-scale data analysis, specifically bulk and single cell RNA-seq, will be considered a plus. Prior experience in skeletal research in addition to the above skills is a plus but not a requirement.

APPLICATION REQUIREMENTS: To apply for this position, please email a cover letter, C.V. and three reference contacts to: Francesca_gori@hsdm.harvard.edu and Roland_Baron@hms.harvard.edu (posted 7.30.20)

 

KOTA LABORATORY
Kota Laboratory at Harvard School of Dental Medicine. A postdoctoral position is available to study mono-allelic gene expression and epigenetic gene regulation of skeletal diseases.
Projects will be focused on understanding the regulation of gene expression in ES cells, MSCs and mouse models of skeletal disease.

Successful candidates will have a strong background in molecular biology, cell biology, and biochemistry. Experience and knowledge in ES cell culture, molecular biology techniques commonly employed in RNA, chromatin analysis, protein biochemistry, RNA-seq, Chip-seq , NGS data analysis and mouse genetics are preferred. The candidate will be expected to work independently and have excellent written and verbal communication skills. This position is granted funded and reappointed annually. The Harvard School of Dental Medicine values diversity among its faculty, is committed to building a culturally diverse intellectual community, and strongly encourages applications from women and minorities. Basic Qualification: PhD in molecular biology, bio-chemistry or cell biology is required.

Additional Qualification: Experience with data analysis and statistical/programming packages (SQL, R, and Linux) preferred. Some prior research experience in public health preferred. Interested candidates can send CV, a brief description of research experience, and contact details of 3 references to: Dr. Satya Kota by email: satya_kota@hsdm.harvard.edu  (posted 6.3.20)

 

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WYSS INSTITUTE (Department job site)

Postdoctoral Fellows Positions at the Wyss Institute for Biologically Inspired Engineering
The Wyss (pronounced "Veese") Institute for Biologically Inspired Engineering uses Nature's design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world.
 Working as an alliance among Harvard's Schools of Medicine, Engineering, and Arts & Sciences, and in partnership with Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Dana Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Tufts University, and Boston University, the Institute crosses disciplinary and institutional barriers to engage in high-risk research that leads to transformative technological breakthroughs.
 
Visit the Wyss Institute's website to find out positions available: http://wyss.harvard.edu/viewpage/191/postdoctoral-positions

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