Open Postdoc Positions

Postdoctoral Positions at HMS Quad-based Labs

The Dean's Postdoctoral Fellowship | Curriculum Fellows ProgramBiological Chemistry and Molecular Pharmacology | Biomedical Informatics | Cell Biology | Center for Bioethics | Genetics | Global Health and Social Medicine | Harvard Catalyst | Harvard Program in Therapeutic Science | Health Care Policy | ImmunologyMicrobiology | Neurobiology | Systems Biology | Harvard School of Dental Medicine | Wyss Institute

This page lists some of the postdoctoral positions currently available on the HMS Quadrangle. Many principal investigators do not advertise their postdoctoral positions with us, so if the PI you want to work with isn't listed here, please contact her/him directly. Please do not send your CV to the administrator of this page.
For non-Quad or external positions please see: postdoc.hms.harvard.edu/job-opportunities

Quad Departments: to have an opportunity listed on this page, send along a description of the postdoctoral position and contact information to us HERE. Please direct any questions to postdoc_office@hms.harvard.edu.

Postdoc openings at other Harvard affiliated institutions:
Beth Israel Deaconess Medical Center | Brigham & Women's Hospital | Children’s Hospital | Dana-Farber | Joslin | Mass General Hospital * | McLean Hospital* | T.H. Chan School of Public Health*
*Please note: some Harvard affiliates do not advertise individual postdoc positions with us, it may be best to identify a PI conducting work in your specific area of interest, and to email that PI directly with your CV and cover letter.


~FEATURED FELLOWSHIP OPPORTUNITIES~

The Laboratory of Systems Pharmacology at Harvard Medical School

The Laboratory of Systems Pharmacology (LSP) at Harvard Medical School tackles difficult problems in translational biomedicine using systems pharmacology approaches that combine laboratory experiments, computer science and clinical studies. Within the LSP, experts in systems biology, basic and translational pharmacology, cell biology, infectious disease, clinical trials, and informatics work closely together to meet the goals of ambitious research programs funded by NIH center and program grants.

LSP projects involve collaboration among multiple faculty members, staff scientists and trainees with very different sets of skills and often based in different departments or institutions. These multi-investigator projects are facilitated by PhD-level scientific managers who help coordinate and integrate the different aspects of each large research project, including pipelines for managing diverse omic data, reagent verification, data curation and validation and communication with the larger scientific community. Scientific program managers play a key role in writing reports for funding agencies, coordination of scientific meetings and often contribute to scientific papers. The LSP scientific program managers will provide LPM fellows with guidance, peer support and mentorship through formal and informal mechanisms.

The LINCS LPM Fellowship
The LSP is recruiting a LPM Fellow in support of the NIH Library of Integrated Network-based Cellular Signatures (LINCS)Center based in the LSP (http://lincs.hms.harvard.edu). The HMS LINCS Center was established in October 2010 to develop experimental and computational strategies to identify cell “signatures” that describe how cells respond to different chemical or biological perturbations. As of March 2017, seven centers across the U.S. participate in the NIH LINCS consortium program. The HMS LINCS Center is identifying signatures that measure the responses of cells derived from different human tissues to therapeutic drugs. Much of the work focuses on cultured cells (from breast, liver and colon), but the Center also studies primary human cells from normal and diseased patients.  As perturbing agents, the focus is on small molecule kinase inhibitors, which are a leading class of therapeutic agents for treatment of cancer, autoimmune and other diseases.

In their research management role, the fellow will collaborate with HMS LINCS investigators to:
-Play a prominent role within the HMS LINCS group curating and organizing experimental data.
-Develop and execute plans for LINCS data releases to public repositories.
-Help to coordinate HMS LINCS data production, data annotation and outreach activities with the work of other LINCS centers.
-Participate in LINCS consortium activities, including regular calls for the Steering Committee, Data Working Group, and Experimental Working Group, and in-person meetings.
-Communicate with the NIH program office regarding required reports, data releases, outreach activities and metrics collection.
-Attend and participate in LSP and Sorger lab group meetings and in the regular and ad hoc meetings involving LINCS PIs, postdocs, students and staff
The Fellow will be appointed as a postdoctoral fellow under LINCS PI and LSP Director Peter Sorger, work on a day-to-day basis with postdocs and staff active in LINCS and receive mentorship and guidance from LSP Scientific Managers and Executive Director.  This position will have a high degree of independence, and opportunities to present at regional and national scientific symposia and workshops.

Requirements:
-PhD in cell biology, biochemistry, molecular biology, pharmacology, systems biology, chemical biology, biophysics or related field
-Demonstrated experience or a strong statement of interest in collaborative research
-Excellent written and verbal communication skills
-Strong organizational and interpersonal skills
-Interest in research coordination and project management

Applications should provide a CV, cover letter and 3 letters of recommendation via email to hits@harvard.edu.
 

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The Dean's Postdoctoral Fellowship

The Dean’s Postdoctoral Fellowship at Harvard Medical School is a two-year research fellowship established to nurture, advance, and retain a diverse scientific workforce that will continue to contribute to diversity through their ongoing academic and research scholarship.  The fellowship program prepares scientists from groups historically underrepresented in the basic and social sciences for careers in academia and other sectors. Fellows benefit from a highly innovative and creative research environment that emphasizes scientific rigor, collaboration, and the pursuit of excellence in science. 

BENEFITS
The two-year fellowship provides funding in the amount of $50,000/year, and DPF fellows are eligible for Harvard’s generous benefits package. They receive additional opportunities for career enhancement, mentorship, seminars, workshops, and conferences, along with a robust support network, through the Harvard Medical School Scholars in Translational and Academic Research (HMS STARs) program.

ELIGIBILITY

·         Have an MD, MD/PhD, PhD, ScD, or equivalent degree in the basic or social sciences.

·         Have United States citizenship or permanent resident status.

·         Come from a background that is historically underrepresented in the basic and social sciences.

·         Have no more than two years of postdoctoral experience.

ELIGIBLE DEPARTMENTS
Fellows conduct research with faculty within the basic and social science departments at Harvard Medical School. For a list of eligible departments, click here.

APPLICATION PROCESS
The application for the Dean’s Postdoctoral Fellowship is available on the DICP website at www.mfdp.med.harvard.edu/deanspostdoc
Applicants need to submit this form along with a cover letter, CV, and a statement that makes the connection between the mission of the Fellowship and their research interests and professional goals.

RECOMMENDATIONS
Three letters of recommendation are required, one of which must be from the applicant’s thesis advisor. For those who have held a postdoc position, the second letter must be from their postdoc advisor.

DEADLINE
Applications are currently accepted on a rolling basis, with the recommendation that they be submitted at least 4 months ahead of the candidate’s anticipated start date. 

SELECTION
Applications are reviewed by a committee comprised of Harvard Medical School faculty and administrators. Fel­lows are selected on the basis of their demonstrated aca­demic achievement, scholarly promise, commitment to research, potential to add to the diversity of the Harvard Medical School community, and the likelihood that the in­dividual may become an independent scientist and societal leader who, upon the completion of the fellowship, will continue to contribute to diversity through their ongoing academic and research scholarship.

Interested candidates are encouraged to contact Lyn Fulton-John, Program Manager, Dean’s Postdoctoral Fellowship Program at dicp_deanspostdoc@hms.harvard.edu or by phone at 617-432-9051 with any questions they may have.

 

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The Harvard Medical School Curriculum Fellows Program (CFP)

I-Hub/TGP Curriculum Fellow in Genetics
The new Ideation Hub (I-Hub) at Harvard Medical School (HMS) in Boston, Massachusetts is seeking an innovative, collaborative science educator to develop teaching curricula, provide student oversight, perform education research, and support the administration of the Harvard Therapeutics Graduate Program (TGP) as the I-Hub/TGP Curriculum Fellow. The postdoctoral trainees within the HMS Curriculum Fellows Program (CFP) work full-time with members of the HMS faculty and administration to develop, deploy, and evaluate evidence-based graduate training. Curriculum fellows (CFs) also receive mentorship and career advising to support their development as educators and help them succeed in a variety of education-focused careers.

The I-Hub is a new initiative developed to build community and catalyze ideation in therapeutic science at all levels at HMS. This is accomplished through financial, administrative and intellectual support for a diverse and inclusive HMS community of therapeutic and translational research scientists from academia and industry. Through its links to industry, the I-Hub aims to support the TGP’s longstanding goal to deliver an innovative training and skills development curriculum that supports a modern approach to therapeutics-related graduate education and career development. In addition to coursework and para-curricular activities, the TGP connects graduate students to real-world industrial, clinical, and regulatory activities in order to train the next generation of researchers in therapeutic discovery and development.

The I-Hub/TGP CF will work directly with key members of the I-Hub executive team, specifically the I-Hub Director and the Executive Director of the TGP, who also serves as Director for Therapeutic Training Programs. The CF will also collaborate with a variety of program faculty, students, and staff to maximize the activities of the I-Hub and the TGP. Specific tasks will include:

  • Support academic activities that enhance rigorous training within the Therapeutics Graduate Program (TGP)
  • Work with the faculty course director of the core TGP course Modern Drug Discovery: From Principles to Patients to evaluate the course, develop new materials and assessments, and manage course content
  • Collaborate with TGP students to organize and support program-related para-curricular activities
  • Provide administrative support to the Pharmacological Sciences NIH T32 grant that supports the TGP
  • Expand opportunities in innovation, entrepreneurship, and professional development for trainees, fellows, and faculty across the I-Hub and its affiliated programs
  • Establish a systematic approach to the collection and analysis of data to assess the effectiveness of I-Hub programs, including trainee and alumni outcomes

Qualifications:

  • An earned Ph.D. in biomedical sciences, preferably in a topic related to therapeutic science
  • Postdoctoral research or teaching experience (preferred)
  • Experience in industry (biotech or pharma) a plus
  • Experience in entrepreneurship activities/education also preferred

Job Skills and Competencies:

  • Outstanding writing, oral, and organizational skills
  • Project or program management skills
  • Motivated, independent, and creative
  • Collaborative in a team setting
  • Excellent social skills
  • Experience working with students, faculty, administrators and professionals

The Curriculum Fellow’s appointment is renewable annually for a maximum of three years and is non-tenure-track. The fellowship is intended for early-career scientist-educators, therefore applications from candidates with more than 5 years of postdoctoral research or teaching experience are discouraged. Fellows are appointed as research associates, with possible promotion to the rank of Lecturer, contingent on experience and performance. The I-Hub/TGP Curriculum Fellow position is open for an immediate start. Applications will be reviewed as they are received until the final submission deadline of 9 AM Eastern Time on Monday, October 28th.

To apply: Applicants should email a single PDF document containing:

  • a letter of application that addresses your interest in and qualifications for the position
  • a curriculum vitae
  • a teaching statement

Email application materials to cfp@hms.harvard.edu, attention Dr. Bradley Coleman, Director of the HMS Curriculum Fellows Program. Include the names and contact information of three references, who will be contacted during the review process. (Posted 9.27.19)
 

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~DEPARTMENTAL LISTINGS~

BIOLOGICAL CHEMISTRY AND MOLECULAR PHARMACOLOGY

The Lassar Lab

The Lassar lab at Harvard Medical School (in the Department of Biological Chemistry & Molecular Pharmacology) has an opening for a postdoctoral fellow to study the transcriptional regulatory network that controls both the formation and maintenance of articular cartilage.  Current efforts are to understand how extracellular signals promote the expression and regulate the activity of a newly identified articular cartilage transcription factor that is essential for articular cartilage formation.  The lab seeks to understand the gene regulatory network that controls synovial joint formation by use of novel genetically engineered mice, isolation of articular chondrocyte precursor populations, RNA-Seq, ATAC-Seq, and ChIP-Seq technologies.  Fundamental knowledge gained from these approaches will be leveraged to develop novel regenerative approaches to treat joint pathology in murine models of osteoarthritis.  

Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry, Genetics or a related field.  In addition, the applicant should be highly motivated, have an excellent working knowledge of molecular biology techniques and be able to work constructively with others.  Prior work with genetically engineered mice and/or regulation of gene expression would be a plus. Interested individuals should send a cover letter, curriculum vitae, and the names/e.mail addresses of three people who could provide letters of reference by email to Andrew_Lassar@hms.harvard.edu. (Posted 9.27.19)

The Coen Lab
Postdoctoral position available: The Coen laboratory in the Department of Biological Chemistry & Molecular Pharmacology has an opening for a postdoctoral fellow to work in collaboration with the laboratories of Dongli Pan, David Knipe, and David Leib on how post-transcriptional mechanisms help regulate the balance between lytic and latent infections of herpes simplex virus.  Experience working on herpesviruses and/or gene expression is helpful, but not required.  If you are interested in applying, please email Don Coen at don_coen@hms.harvard.edu, including a curriculum vitae, a description of previous research, and the names and email addresses of three people who can serve as references. (Posted 7.10.19)

Postdoctoral Research Fellow and Project Manager, Translational Metabolism Research
Job Description: The Sheu Lab at Brigham and Women’s Hospital and the Devlin Lab at Harvard Medical School are currently seeking a talented, driven, PhD-level scientist to lead these labs’ joint effort to develop a novel therapeutic for the treatment of type 2 diabetes mellitus (T2D) and obesity. Dr. Eric Sheu is an Assistant Professor of Surgery at Brigham and Women’s Hospital. The Sheu lab studies mechanisms of diabetes remission following bariatric surgery.  Dr. Sloan Devlin is an Assistant Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. The Devlin lab uses strategies from chemical biology to understand how small molecules produced by human gut bacteria affect human health and disease.
This position is a unique opportunity for a postdoctoral fellow to lead a research team and work at the intersection of academia and industry. This postdoc, along with the principle investigators, will develop a novel T2D therapeutic using in vitro and in vivo models of diabetes. This individual will both perform experiments in-house and will also plan and manage studies carried out at contract research organizations. The position will involve significant interactions with industry, venture capital, and private funding agencies. This position provides an excellent opportunity any person interested in drug discovery to jump-start his/her career in translational science.
Qualifications:

  • Innovative experimental biologist with significant previous basic science research experience who has a strong interest in accelerating scientific discoveries to the clinic.
  • Ph.D. and/or M.D. or graduating with a PhD by summer of 2019.
  • Background and expertise with mouse models of obesity and diabetes, including glycemic and insulin tolerance testing, are highly desired.
  • Experience in molecular / cell biology, specifically in relation to the study of metabolism, is preferred.
  • Strong history of publication in peer-reviewed journals.
  • Ability to work effectively with interdisciplinary teams.
  • Excellent oral and written communication skills.

Please send cover letter, C.V., and references to BOTH Eric Sheu, MD, PhD and Sloan Devlin, PhD. (Posted 5.22.19)

The Arthanari Lab
The Arthanari Lab at Department of BCMP, Harvard Medical School and Department of Cancer Biology, Dana Farber Cancer Institute is seeking a highly motivated postdoctoral candidate with expertise in transcriptional biology. Our laboratory works at the interface of structural biology, drug discovery and mechanistic biology, focusing on transcription factors and their interactions with co-activators and mediators (e.g. Nature 2016 25;530 (7591): 485-9; Nature 2008 452 (7187): 604-9). Research efforts will be focused on the intersection of cancer biology/genetics and immune-oncology. The candidate is expected to have a comprehensive understanding of signaling pathways, epigenetics and transcription regulation. Experience in technical skills including cell culture, somatic genetic analysis (e.g., CRISPr, si-, sh- RNA knockdown and rescue), protein biochemistry, assay design and development and biological applications to advance discovery are preferred. The individual should be independent and passionate about science and have an established record of creativity, ability to work in teams and strong publication record in peer-reviewed scientific journals.
Interested applicants should send a CV, and the names/phone numbers of three references by email to hari@hms.harvard.edu

Blacklow Laboratory at Harvard Medical School
The Blacklow Laboratory at Harvard Medical School (Department of Biological Chemistry and Molecular Pharmacology) has an opening for a Postdoctoral position. The laboratory currently investigates structure-function relationships in Notch signaling, its downstream targets, and its epigenetic regulators.
Applicants should possess a Ph.D. and/or M.D. degree in Molecular Biology, Cell Biology, Biochemistry, Structural Biology or a related field.
Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to jobs_blacklowlab@hms.harvard.edu.

The Brown Laboratory
Postdoctoral Fellow in Electron Cryomicroscopy (Full posting: https://brown.hms.harvard.edu/jobs/93)
Position Description: A postdoctoral position is available in the Brown lab at Harvard Medical School. The lab uses the latest developments in cryo-EM to understand biological processes at the molecular level (e.g. Nature 524, 493–496 and Science 346, 718–722). The project will involve investigating the structure and function of large macromolecular complexes involved in cellular transport. This includes all steps from construct design to structure determination. In the long term, we aim to use detailed molecular models to facilitate the development of new and better therapeutics.
Job requirements: Applicants should hold (or will be shortly awarded) a PhD degree and have experience in molecular biology and protein purification. Prior experience with single-particle cryo-EM or X-ray crystallography is considered a major advantage. Candidates should have strong communication skills and an established record of creativity through principal authorship in peer-reviewed publication(s). The successful candidate should be passionate about science, motivated, proactive, and able to work in a team. While each lab member has their own project, lab members are encouraged to work together to solve common problems. A separate position is available for an outstanding candidate with expertise in electron cryotomography (cryo-ET).
The position is initially for 2 years with a possibility of extension.
If you’re interested in joining the lab, please send your CV with a brief description of your current research as well as 2-3 contacts for references to Alan_Brown@hms.harvard.edu before the 8th August, 2017.

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BIOMEDICAL INFORMATICS

Patel Group - Postdoctoral Fellows (posted 4.5.19)

The Department of Biomedical Informatics (DBMI) at Harvard Medical School is seeking a Postdoctoral Fellow with experience in database management (SQL), scientific programing (Python, R) and cloud computing (AWS, Google Cloud Platform) and an interest -- but not necessarily experience -- in biomedical data science (or related field, such as population genetics, biostatistics, or epidemiology). You will work with investigators from the Patel Group and Arjun Manrai, faculty members at HMS DBMI and build tools and computer infrastructure to enhance use of large and disparate datasets from the domains of biology and population health to enable precision medicine. The goal of our efforts is to usher in a new age of precision medicine through combining lab, ancestry, demographic, environmental, and genetic data to enable accurately classify disease and health that accounts for the diversity of the human population.
Job listing on Department website: 
https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/patel-group-0
Email applications including curriculum vitae, summary statement of personal objectives, and the names and email addresses of 2-3 references to Chirag Patel (chirag_patel@hms.harvard.edu).

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Postdoctoral Positions in the Lab of Paul Avillach (posted 2.12.19; updated 11.15.19)

1) Phenotype extraction and biomedical ontologies
Summary
The Department of Biomedical Informatics (DBMI) at Harvard Medical School is looking for a Postdoctoral Fellow to help build cutting edge research platforms. The real value in biomedical research lies not in the scale of any single source of data, but in the ability to integrate and interrogate multiple, complementary datasets simultaneously. We are combining clinical and genomics data across different scales and resolutions to enable new perspectives for essential biomedical questions. The research focuses on the development of novel methods and techniques for the integration of multiple heterogeneous clinic cohorts, Electronic Health Records data and multiple types of genomics data to encompass biological observations.

Responsibilities
The Postdoctoral Fellow will be responsible for developing novel methodologies and applications to facilitate high-throughput phenotype extraction, harmonize content with biomedical ontologies and integrate clinical and molecular genomic data.
The diversity of subject matter will require a creative mind and a candidate capable of deploying imaginative strategies and who is dedicated to solving complex and challenging problems within an interdisciplinary environment.

Basic Requirements
Candidates must have a PhD degree (or MD/PhD) in biomedical informatics, bioinformatics, Computational Biology, computer science, or a related field. Curriculum in and/or experience with standardized ontologies, terminologies, metadata, and related technologies as well as experience in programming and software development will be necessary for this opportunity. The candidate interested in this position must be highly motivated, willing to learn and demonstrate initiative in assigned tasks. Excellent written and verbal communication skills are crucial.

Additional Requirements
Preferred requirements for this position include experience with the Unified Medical Language System (UMLS), statistics, data mining and machine learning. Experience with R, Python, and/or Perl is desirable.

Terms
The position is available immediately and can be renewed annually.

How to apply
Email applications including curriculum vitae, summary statement of personal objective and research interests, PDFs of the best two papers, and the names and email addresses of three references to paul_avillach@hms.harvard.edu

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2) Post-Doctoral Fellowship at Harvard-MIT Center for Regulatory Science | Harvard Program in Therapeutic Science
The Harvard Program in Therapeutic Science (HiTS) invites applications for a fellowship position at the Harvard-MIT Center for Regulatory Science. The fellow will work with a multidisciplinary team to develop and evaluate novel computational methods to support automated detection of drug-drug interactions in large and disparate healthcare datasets.
ABOUT THE FELLOWSHIP PROGRAM
The Harvard-MIT Center for Regulatory Science is a partnership between Harvard, MIT and the FDA, focused on building innovative approaches for the development and evaluation of medical products. Working across academia, industry, and government institutions, the Center promotes regulatory science through research and education programs, uniting stakeholders under a common mission: promoting optimal patient health outcomes through biomedical innovation and the availability of safe and effective diagnostics and treatments. The Regulatory Science Fellows Program draws individuals of diverse experiences who are passionate about using novel applications of data science to improve the use of therapeutics in patient populations.
For this position, the Fellow will work with faculty at Harvard in the Department of Biomedical Informatics https://dbmi.hms.harvard.edu. The fellow will be based in the Avillach Lab, an interdisciplinary research group focused on the development of cutting edge techniques for the integration of multiple heterogeneous biological and clinical cohorts with the overarching goal of supporting individualized data-driven healthcare.
PROJECT DETAILS
The application of  healthcare claims data and electronic health records for use in pharmacoepidemiological studies is booming. Drug–drug interactions can be identified by mining such databases, including adverse drug reactions (ADRs) resulting from the prescription of a combination of drugs (CADRs), considered a special class of drug-drug interactions. While many ADRs can be anticipated and hence avoided, CADRs are highly complex and challenging to identify and, as a consequence, have not been well studied. CADRs may represent as many as 30 % of unexpected ADRs and their elucidation is of particular interest to the FDA.

The fellowship project will develop new signal detection algorithms using data mining techniques in real-world healthcare data derived from claims and electronic healthcare records. The project will aim to identify potential pharmacovigilance signals concerning drug-drug interactions across multiple diseases and syndromes.
Research activities include, but are not limited to:
- Extract and analyze information from a nationwide claims database including 67 million subjects
- Extract and analyze information from healthcare records in an academic pediatric hospital including 1.8 million patients
- Develop and test methods to detect adverse drug reactions from billing codes, drug prescriptions and lab value results
- Disseminate findings through national and international conferences and in peer-reviewed scientific publications
Basic Qualifications
PhD in computer science, engineering or a related field; Expertise in SQL query language; Expertise in R or Python programing languages
Application Procedure and Requirements
Applications will be accepted until the position is filled. Please include the following when applying: Curriculum vitae; Cover letter and a 2-page description of relevant experience as a single PDF; DOI or PMCID of up to three relevant publications. Selected candidates will be asked to provide letters of reference.

Additional Position Description
Host Institution: Harvard Medical School | Appointing Department: Harvard Program in Therapeutic Science |Research Laboratory: Paul Avillach |Location: Boston, MA |Category: Scientist |Other responsibilities: no administrative or teaching obligations |Duration of fellowship: 2 years

Contact: Paul Avillach, MD, PhD, Department of Biomedical Informatics, 10 Shattuck Street, Boston, MA 02115

 

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Postdoctoral Positions in the Lab of Maha Farhat

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Postdoctoral Positions in the Lab of Peter Kharchenko  (posted 2.12.19)
Job Description
The Department of Biomedical Informatics (DBMI) at Harvard Medical School and the Kharchenko Lab is looking to recruit several postdoctoral fellows interested in pursuing one or more of the following topics in computational biology:

Single-Cell Genomics
The fellow will be charged with developing novel statistical approaches to the analysis of single-cell genomic data, mathematical modeling of cellular processes, as well as applications of such techniques to study healthy and diseased tissues. Strong background in statistics, modeling of stochastic processes and multicellular systems is desired.

Computational analysis of epigenetic mechanisms disrupted in cancer and other disease-disrupted tissues
The fellow will be responsible for developing and applying computational methods for integrative analysis of genome-wide epigenetic, transcriptional and proteomic data, aiming to identify specific factors and molecular mechanisms underlying misregulation of the epigenetic states in several types of human cancer. The ideal candidate should have a strong quantitative background, ample experience with analysis of sequencing assays, and strong interest in cancer biology.

Computational analysis of nucleosome organization
The fellow will be part of the central analysis group for the extensive 4D-nucleus consortium project funded by the NIH. The efforts will be focused on the development of analysis techniques for the next generation of experimental methods for measuring organization and dynamics of the eukaryotic nucleus that are being developed by the members of the consortia. Experience with analysis of Hi-C and relevant imaging data is strongly preferred.

All projects are being conducted in close cooperation with the expert bench-side laboratories, providing an excellent opportunity for collaborative research. Harvard Medical School and the Department of Biomedical Informatics also provides for a rich scientific environment, with a number of relevant seminar series, invited speakers, and many neighboring laboratories working on related projects.

PhD in Computational Biology, Statistics, Physics or other related discipline is required. A strong record of publications in the field is desired.

To apply – please send cover letter, curriculum vitae and contact information for at least two references to Dr. Peter Kharchenko at peter_kharchenko@hms.harvard.edu. Applications will be considered until the positions are filled. Please specify which project you are interested in.

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Kharchenko Lab: Postdoctoral Opportunities (posted 1.28.19)
Single-cell Transcriptomics, Epigenetics | Spatially-resolved Transcriptomics | Gene Regulation | Cancer Heterogeneity, Therapy Resistance, Immune Microenvironment | Tissue Organization

A group led by Peter Kharchenko at the Department of Biomedical Informatics of the Harvard Medical School is searching for postdoctoral fellows interested in developing and applying novel statistical, computational and experimental approaches to study challenges posed by cancer biology and development/maintenance of healthy tissues at a single-cell resolution. The research questions are being pursued in close cooperation with expert bench-side laboratories, providing an excellent opportunity for collaborative research. In particular, we are looking for researchers interested in joining our efforts on single-cell atlas of human brain, lung, kidney and other organs as part of the NIH funded BRAIN and HuBMAP consortia. Fellows interested in application of advanced image analysis techniques to study organization of biological tissues are encouraged to apply.

More info at
http://pklab.med.harvard.edu/

Areas of Interest: Single-Cell Analysis, Spatial Analysis, Statistics, Cancer, Tissue homeostasis

Candidate qualifications:
- Robust knowledge of statistical methods, and probabilistic modeling techniques
- Experience with quantitative analysis of modern biological assays
- We welcome experience in image analysis, graphical models, and advanced machine learning
- A strong interest in conducting collaborative research
- Track record of publications in peer-reviewed journals

How to apply: Please send cover letter, curriculum vitae and contact information for at least two
references to Peter Kharchenko at peter_kharchenko@hms.harvard.edu. Applications will be considered until the position is filled.

Employer: Department of Biomedical Informatics has been recently formed at the Harvard Medical School to lead development of computational and informatics techniques to address pertinent challenges in modern biological sciences and medicine. The Department’s faculty conduct research at the intersection of biomedicine and information sciences, including bioinformatics, functional genomics, translational medicine, and clinical knowledge management. The Department also hosts the Bioinformatics & Integrative Genomics PhD program (sponsored by NHGRI) and the Biomedical Informatics Masters program.

Harvard Medical School is an Equal Opportunity/Affirmative Action Employer.

Women and minorities are especially encouraged to apply.

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Gehlenborg Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/gehlenborg-lab

Kharchenko Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/kharchenko-lab

Patel Laboratory at Harvard Medical School
For details and additional information: https://dbmi.hms.harvard.edu/careers/postdoctoral-fellows/patel-group

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CELL BIOLOGY

Yuan Laboratory at Harvard Medical School
The Yuan laboratory at Harvard Medical School (Department of Cell Biology) has an immediate opening for a postdoctoral scientist. Our laboratory investigates the molecular mechanisms of cell death, including necroptosis and apoptosis, and their relevance for human diseases. This position is for a highly motivated individual with considerable experience in cell biology or related field. Experience in animal models of human diseases is desirable but not required.

Applicants should possess a Ph.D. and/or M.D. degree in molecular biology, cell biology, biochemistry, or neurobiology and a strong publication record. Interested individuals should send a curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to junying_yuan@hms.harvard.edu.

For additional information please visit our webpage: https://yuan.med.harvard.edu/


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CENTER FOR BIOETHICS

The Harvard Medical School Center for Bioethics invites applications for the Postdoctoral Research Scholars Program in Bioethics, for appointments commencing in summer/fall 2018.

This 1-2 year program prepares scholars with the knowledge and skills necessary to become leaders in the field of bioethics. Research scholars are fully integrated into the community of faculty and students at the Center for Bioethics, with access to the resources of Harvard Medical School and Harvard University. The program includes opportunities to collaborate with the scholars at the Hastings Center. We are particularly focused on attracting candidates with an interest in working on ethical and policy issues in regenerative and synthetic biology, genetic engineering, stem cell biology and embryology. Ideal candidates would be promising scientists in these areas with a background in bioethics or with a serious commitment to gaining expertise in the field
Research scholars will receive an annual stipend, benefits, and an allotment for academic expenses and travel.

The core experience includes:

  • Mentored research. Research scholars work closely with faculty mentors from across Harvard University to develop and conduct original research in the field of bioethics. A primary aim of the program is to prepare candidates with the training necessary to obtain competitive research funding and develop a successful academic career in bioethics.
  • Educational opportunities. The program seeks candidates with diverse backgrounds, experience, and knowledge. Each scholar works with faculty creating a personalized educational program that will delve into special areas of interest, as well as developing broad expertise in the field of bioethics. Research scholars have access to all the Center's courses and seminars, and may be able to audit relevant courses across Harvard University with faculty permission.
  • Community life. Postdoctoral research scholars will be fully engaged with the activities of the Center and the Harvard-affiliated teaching hospitals. Scholars will organize and conduct conferences and seminars, they will assist in teaching courses in their areas of interest, and will have opportunities to participate on hospital clinical ethics committees and institutional review boards.

In short, the Postdoctoral Research Scholars Program provides the greatest possible access to all that Harvard University has to offer.

Application Requirements:
Applications are invited from those who have or will have completed a doctoral degree (MD, JD, PhD or equivalent) by July 1, 2018. Doctorates may be in any relevant field, including but not limited to public health, psychology, economics, philosophy, sociology, or anthropology.
The deadline for summer/fall 2018 is March 30, 2018. Applications may be considered throughout the year under special circumstances.
Visit the website for application requirements: 
http://bioethics.hms.harvard.edu/postdoctoral-program


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GENETICS

Yankner Laboratory at Harvard Medical School

Postdoctoral positions available to study gene regulation, epigenetics and the molecular biology of aging and neurodegenerative diseases.  Projects focus on iPS cells, C. elegans, animal models and the biology of genes involved in aging and Alzheimer's disease. For reference see:   Nature. 2019;574(7778):359-64. Epub 2019/10/18, Cell Reports 2019 doi.org/10.1016/j.celrep.2019.01.023, Nature 507:448, 2014. Experience in molecular biology is required.

Send CV, a brief description of research experience and names of 3 references to: Dr. Bruce Yankner by email to marianna_liang@hms.harvard.edu

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GLOBAL HEALTH AND SOCIAL MEDICINE

Global Health and Social Medicine | Blavatnik Institute - Research Fellowship in Indigenous Community Well-Being
This fellowship will pursue innovative interventions for mental health problems in (post)colonial Indigenous settings in the USA. It would operate under the supervision of Prof. Joseph Gone, Faculty Director for the Harvard University Native American Program, and in collaboration with regional and national Indigenous community partners.

The Project

The Department of Global Health and Social Medicine seeks a postdoctoral fellow to coordinate a new action-research project dedicated to advancing Indigenous Partnerships for Community Well-Being. Many Indigenous peoples in the USA experience overwhelming social problems stemming from legacies of conquest and dispossession that have led to unremitting poverty. These problems include mental health inequities such as high community rates of trauma, addiction, and suicide. And yet, conventional clinical approaches to helping individuals with psychological distress and disability are not always well-tailored for Indigenous communities. By engaging in participatory fashion with knowledgeable and resilient Indigenous community partners, the Indigenous Wellness project will assess the relevance, efficiency, and effectiveness of mental health and psychosocial helping services and, together with community partners, re-imagine and re-design such services toward greater cultural consonance, therapeutic benefit, and community self-determination. In-depth consultation with community leaders, traditional healers, and other local knowledge carriers—and circulation of lessons learned through routine academic publication and community dissemination—will be essential to the success of these endeavors. Contributions to scientific knowledge may include formal outcome evaluations of innovative services, as well as more basic research that will elucidate Indigenous experiences and understandings of health, healing, and well-being. In sum, the signature contribution of this endeavor entails the reflective, collaborative, and documented development of innovative interventions for mental health problems in (post)colonial Indigenous settings in the USA.

Responsibilities

Under the supervision of Prof. Joseph Gone, Faculty Director for the Harvard University Native American Program, and in collaboration with regional and national Indigenous community partners, the fellow will assume mentored responsibility for: (1) advancing research projects, analyzing associated data, writing manuscripts, and submitting these for publication; (2) coordinating existing partnerships and supporting new partnerships toward efficient and effective action-research dedicated to services innovation; (3) managing the logistics of community-engaged action-research, including ethics review, financial reporting, grant preparation, etc.; (4) consolidating a relevant network of community-engaged researchers and Indigenous knowledge keepers who are committed to promoting innovative Indigenous wellness projects; and (5) supervising students, trainees, and volunteers who contribute to these efforts. Ability to travel routinely to project sites, whether regional or national, is required.

Qualifications

Applicants must have a doctoral degree in a field relevant to this project (e.g., psychology, medical sociology, medical anthropology, social work, public health). Other desirable qualifications include:

  • Record of scholarly publication, including first-authored scientific journal articles
  • Expertise in research design, intervention outcomes assessment, and/or qualitative data analysis (e.g., thematic content analysis, ethnography)
  • Experience working in or collaborating with Indigenous communities in the USA
  • Prior supervision of research team and/or coordination of community research activities
  • Current knowledge of mental health problems and services in the USA

To apply:
Email the following items in one PDF with the surname as the first word of the PDF file: (1) cover letter stating long-term career aims, interest in the project, and suitability for the position, specifically referring to the criteria listed above; (2) curriculum vitae; (3) two or three relevant publications; and (4) contact information for three to five potential references. Applications should be emailed to: rebecca_grow@hms.harvard.edu

Minimum salary: $55,000
Start date: September 1, 2020
Location: Boston/Cambridge, MA, USA
Other information: This project is expected to be ongoing. The research fellow position will be hired on an annual basis with renewal depending on continued funding and satisfactory performance.

For additional information regarding the PI, associated research, and project institutions, see
http://gonetowar.com https://ghsm.hms.harvard.edu/person/faculty/joseph-gone http://ghsm.hms.harvard.edu
For additional information regarding the project or the post, please email: Professor Joseph Gone (jgone@g.harvard.edu)

Harvard University is an Equal Opportunity, Affirmative Action employer and applications from women and underrepresented minorities are strongly encouraged.

Post-Doctoral Fellowship in Integration Science at the Harvard Medical School Program in Global Noncommunicable Disease and Social Change

The Program in Global Noncommunicable Disease and Social Change (PGNDSC) at Harvard Medical School (HMS) is offering a Post-Doctoral Fellowship that focuses on evaluating the cost and impact of integrated service delivery strategies for severe noncommunicable diseases and injuries (NCDIs), such as type 1 diabetes and rheumatic heart disease, in highly constrained health systems.

The candidate will need to be well versed in working with implementers in limited-resource settings and supporting local staff in developing rigorous academic outputs. Expertise in examining health as well as economic outcomes is ideal for this position. Standard knowledge of design and analysis of data based on epidemiological studies is required. Experience with intervention costing and/or cost-effectiveness analysis is desirable. A familiarity with noncommunicable diseases and implementation science is needed.

A commitment of two years is required, which will allow the Fellow to establish rapport with colleagues at the country sites as well as advance his/her career towards becoming an independent researcher through drafting first author publications and developing proposals for NIH funding. Significant travel to international sites to work collaboratively with local staff to identify how to utilize existing data for operational research and cost analysis on NCDs.

Primary supervisor: Gene Bukhman, MD, PhD.

Basic Qualifications

  • Graduate degree (PhD) in public health (program with a focus on Epidemiology or quantitative methods required)
  • Experience in analysis of cost-related data, such as cost-effectiveness analysis
  • Experience in epidemiological study design and analysis of health outcome data
  • Extensive experience with Stata software (also experience with 'R' preferred)
  • Prior experience working in the field in a resource-limited setting
  • Experience working on data management with in-country staff

Familiarity with non-communicable diseases as a subject area for implementation science

Application Instructions

Interested applicants should submit the following to Rebecca Grow (rebecca_grow@hms.harvard.edu) in the Department of Global Health and Social Medicine at HMS for consideration: CV, cover letter outlining interest in the role, publication examples (up to 3 articles of published work that include examples using general health outcomes as well as cost analysis), and names of three references. Send the materials as one PDF named [Last name]-[First name]_NCD-fellow_2019.

View full job posting HERE and additional Global Health and Social Medicine Fellowship listings HERE. (Posted 9.3.19)
 

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HARVARD CATALYST

No positions currently listed.

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HARVARD PROGRAM IN THERAPEUTIC SCIENCE (HiTS)

Postdoctoral Fellowship for Geographic Information Systems (GIS) to Pathology | HiTS | HMS
Description: The objective of this project is to apply methods developed for the analysis of geographic and ecological features in GIS (Geographic Information Systems) to the understanding of human cancers. This will involve applying geospatial analytics, spatial and spatiotemporal statistics, environmental image processing, and ecosystem modeling techniques to human tumor images collected using very recently developed methods. The study aims to characterize patterns, relationships, and interactions among tumor cells, immune cells, and healthy cells based on these landmarks before, during, and after exposure of patients to therapeutic drugs.The position involves a joint appointment between the Harvard University Center for Geographic Analysis (CGA) and the Harvard Medical School Laboratory of Systems Pharmacology (LSP). The candidate will have space assigned at both the CGA and LSP and will attend group meetings and similar activities at both research centers. The appointment is for one year with the possibility of renewal based on satisfactory performance and continued availability of funding. This position has no teaching or administrative duties.

Qualifications: The successful candidate will have an MD and/or PhD and relevant experience in cancer immunology and/or breast or ovarian cancer research, geographic information science, remote sensing, or a related field. Interest in biological imaging is required. Prior experience working with mouse or human tissues and mastery of basic molecular biology techniques and cell culture are required.  Proficiency in fluorescence microscopy and/or single cell methods such as flow cytometry/CyTOF are also highly desirable.  The candidate should have an interest in acquiring skills in image processing and analysis and use of computational pipelines to produce and analyze single-cell data. A general understanding of Matlab/Python and prior experience in working with mouse or human tissues, including familiarity with tissue processing and analysis as well as basic knowledge of standard IHC is preferred. Excellent written and spoken English are required.

To apply, send a curriculum vitae, statement of research interests, and names and contact information for three references to Laura Maliszewski (laura_maliszewski@hms.harvard.edu). Research papers (up to three) are welcome but optional. Review of applications will begin immediately and end when the position is filled. Incomplete applications will not be reviewed. More information HERE. (Posted 8.30.19)

Postdoctoral Fellowship for Innovative Single-Cell Discovery Platform for Women’s Cancers | HiTS | HMS
Description: The Harvard Medical School (HMS) Laboratory of Systems Pharmacology (LSP) and Women’s Cancer Program at Dana-Farber Cancer Institute (DFCI) seeks an outstanding postdoctoral fellow who will use innovative single-cell methods to study mechanisms of immunotherapy response and resistance in patient tumors.  The fellow will be based in the laboratories of Dr. Peter Sorger at HMS and Dr. Beth Mittendorf at DFCI, where he/she will routinely interact with physicians, basic scientists and computational biologists to conduct high impact translational research.  The fellow’s research efforts will directly inform the design of novel clinical trials of immunotherapy for breast and ovarian cancer. The fellow will lead efforts to apply single cell genomics and imaging, including a new tissue-based, multiplexed immunofluorescence assay (tCyCIF: www.cycif.org) to study the tumor microenvironment in breast and ovarian tumors.  The high-dimensional single cell data will be used to identify novel cell types, functional states and drug targets. This position has no teaching or administrative duties.

Qualifications: The successful candidate will have an MD and/or PhD and relevant experience in cancer immunology and/or breast or ovarian cancer research.  Prior experience working with mouse or human tissues and mastery of basic molecular biology techniques and cell culture are required.  Proficiency in fluorescence microscopy and/or single cell methods such as flow cytometry/CyTOF are also highly desirable.  The candidate should have an interest in acquiring skills in image processing and analysis and use of computational pipelines to produce and analyze single-cell data.   A general understanding of Matlab/Python and prior experience in working with mouse or human tissues, including familiarity with tissue processing and analysis as well as basic knowledge of standard IHC is preferred.  Excellent written and spoken English are required.

To apply, send a curriculum vitae, statement of research interests, and names and contact information for three references to Laura Maliszewski (laura_maliszewski@hms.harvard.edu). Research papers (up to three) are welcome but optional. Review of applications will begin immediately and end when the position is filled. Incomplete applications will not be reviewed. More information HERE. (Posted 8.30.19)

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HEALTH CARE POLICY

No positions currently listed.

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IMMUNOLOGY

No positions currently listed.

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MICROBIOLOGY

Research Scientist, Molecular Virologist | Department of Microbiology | HMS
The Yang Group is currently recruiting a molecular virologist to work with a team of medicinal chemists, biochemists, and structural biologists in developing novel small molecule antivirals.  Preference will be given to individuals with prior experience with flaviviruses, but applicants with experience in any area of positive-strand RNA virology are encouraged to apply.  Most important is that you thrive working in a collaborative and fast-paced environment and that you are willing to learn and evolve as a scientist.  This is a great research scientist level position if you aren’t sure or if you are sitting on the academia versus industry fence, because you can learn skills relevant to industry while still training in an academic environment (i.e. answering questions is more important than making products).
Qualifications: A Ph.D. in molecular virology, including prior work with flaviviruses and/or hepatitis B virus is preferable.  Must be proficient in molecular biology techniques required for performing reverse genetics experiments to generate and characterize recombinant viruses.  Experience in analyzing viral gene expression and viral genome replication. Ability to independently design experiments to address mechanistic questions.  Excellent quantitative and communication skills and an ability to collaborate are essential.
Interested candidates should email Priscilla_Yang@hms.harvard.edu and include a cover letter, CV, statement of professional interests, and contact information for three letters of reference. Applicants may also send the material to Dr. Priscilla Yang, Department. of Microbiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA  02115. (Posted 6.14.19)

Abraham Laboratory at Harvard Medical School
The Abraham laboratory in the Department of Microbiology at Harvard Medical School is seeking a highly motivated postdoctoral candidate with expertise in virology, molecular biology, and genome editing (CRISPR/Cas9). Our laboratory uses a wide-array of approaches to study how emerging pathogens interact with cells and immune systems of their hosts. The project will involve performing genetic screens to probe host-pathogen interactions. Strong candidates would have extensive experience with mammalian tissue culture and viral infectivity assays. Publications from our laboratory include: Mahmutovic S et al. Cell Host & Microbe 2015, and Clark LE et al. Nature Communications 2018.
Interested applicants should send a CV, including the names/email addresses of 2-3 references, to abraham@crystal.harvard.edu  (11.26.18)

Gehrke Laboratory at Harvard Medical School
The Gehrke laboratory is looking for a U.S. citizen postdoc to join a team that is studying neurotropic virus infections using 2D and 3D tissue models.  Applicants must have Ph.D. or M.D. degree with a background in virology and familiarity with molecular techniques.  The work will involve BSL3 pathogens. Available immediately. Please send inquiries to lee_gehrke@hms.harvard.edu. (6.2.17)

Nibert Lab
August 20, 2018 - Postdoc Position available immediately
Available position: Postdoctoral research associate
Location: Nibert lab, Department of Microbiology, HMS (NRB-939, 77 Ave Louis Pasteur)

Project: Molecular biology of Trichomonas vaginalis viruses, including genomic characterizations, dissection of packaging/replication/translation signals, and structure-function studies of virus particles and proteins
Job Responsibilities include: Working collaboratively to design experiments, perform experiments, analyze data, present data to academic colleagues, prepare manuscripts.

Please email a CV, cover letter, and names of at least two references to:
Max Nibert, Professor of Microbiology
mnibert@hms.harvard.edu


Yang Laboratory at Harvard Medical School
The Yang Lab has two immediate openings for postdoctoral fellows to play a vital role in the discovery and optimization of small molecule antivirals. Must have established expertise in protein expression (microbial, insect, and mammalian cells) and purification as well as with a variety of biophysical and biochemical methods for characterizing protein-small molecule interactions. Experience with high-throughput screening and/or molecular virology techniques is desired but may be substituted with a willingness and aptitude to learn. Must be willing to work with viral pathogens in a BSL2+ lab.

You will be working within a multidisciplinary group of structural biologists, medicinal chemists, biochemists, and virologists. This position requires excellent communication and organizational skills, and a willingness to help train and mentor more junior members on the research team. This is an excellent opportunity for a post-doctoral fellow to acquire experience relevant to future employment in industry while still operating within an academic environment. This position is funded by an NIH grant through 2018. Applicants are expected to make a 3 year commitment.

Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Priscilla L. Yang., Ph.D.
Department of Microbiology and Immunobiology
Harvard Medical School
Email: Priscilla_yang@hms.harvard.edu


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NEUROBIOLOGY

Regehr Lab – Postdoctoral Positions
Two positions are available. The first is to study short-term synaptic plasticity using a combination of electrophysiological, anatomical and molecular approaches. The second is to study cerebellar circuitry and the role of the cerebellum in motor and social behaviors. Applicants should email a cover letter, CV and the names of three references with contact information to: wade_regehr@hms.harvard.edu  (posted 3.29.19)

 

Harwell Lab - Postdoctoral position to study the cellular and molecular mechanisms of neural circuit assembly.
The Harwell lab in the Department of Neurobiology at Harvard Medical School is seeking postdoctoral fellows to study the development of neural circuits. We are primarily focused on understanding the cellular and molecular mechanisms that govern the production and assembly of neural circuits in the basal forebrain. We employ a diverse array of tools and techniques including mouse genetics, next generation sequencing technologies such as ChIP-seq and single-cell RNA-seq, optogenetics and electrophysiology, to understand the intrinsic molecular programs that specify neural cell identity and orchestrate assembly of neural circuits.
Ideal candidates will be creative, highly motivated individuals with excellent communication and interpersonal skills, with a strong background in cellular and molecular neurobiology. Desirable skills include whole cell patch-clamp electrophysiology and computer programming experience, but are not required. We offer a highly supportive and collaborative environment for addressing fundamental questions in developmental neurobiology. Prospective candidates should send a cover letter, C.V. and contact information for 3 referees to: Corey Harwell, Assistant Professor of Neurobiology, corey_harwell@hms.harvard.edu. Website: www.harwelllab.hms.harvard.edu (posted 3.29.19)

 

Pecot Lab at Harvard Medical School (posted 3.13.19)
The Pecot Lab in the Department of Neurobiology at Harvard Medical School is seeking postdoctoral researchers interested in studying the molecular basis of precise neural connectivity. The goal of our research is to identify general molecular and cellular principles that underlie how neural networks are assembled. We address this at the level of identified cell types and synapses in the fly visual system. We are interested in the molecules that underlie how neurons distinguish each other and form synapses with appropriate partners, and in determining the gene regulatory networks that give rise to the expression of these genes in specific cell types. We employ a diverse experimental approach, involving molecular genetics, transcriptome profiling, genomics, confocal and superresolution microscopy, calcium imaging, and electron microscopy. Training in neuroscience or fly genetics is welcome but not necessary. We offer a supportive, collaborative and creative environment. 

Please email a cover letter, a curriculum vitae, and names & email addresses of three references to:
Matthew Y. Pecot, Ph.D.
Department of Neurobiology
Harvard Medical School
Armenise 203
Boston, MA 02115
Email: matthew_pecot@hms.harvard.edu
Website: www.pecotlab.com

 

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Born Lab (and Haefner Lab)  (posted 3.12.19)
TWO (EXP+THEORY) POSTDOCTORAL FELLOWSHIPS IN SYSTEMS NEUROSCIENCE
Perceptual decision-making in a probabilistic inference framework
The laboratories of Rick Born in the Dept. of Neurobiology at Harvard Medical School, and Ralf Haefner in the Dept. of Brain & Cognitive Science at University of Rochester, are seeking applications for two NIH-funded postdoctoral fellowships to study the role of top-down connections in conveying learned priors within a theoretical framework of perception as probabilistic inference. Specific projects will address the neural bases of multi-tasking and confirmation bias. Experimental techniques include population recordings from area V1 with and without cortical feedback inactivated by cooling V2/3. Data analysis techniques include applying latent-state inference methods. Theoretical work will involve generating empirically testable predictions using sampling-based and variational techniques applied to probabilistic models.
Link to full posting

The successful candidates will interact extensively with each other, both PIs and their labs. Please visit the lab web sites (Born Lab & Haefner Lab) to obtain more information on current interests and electronic versions of recent research papers. Preliminary results from a closely related project on learning can be found here.
The ideal candidate for the experimental position will have experience in one or more of the following areas: training nonhuman primates, extracellular electrophysiology, reversible inactivation of cortex, MATLAB programming. Candidates with a computational neuroscience background and an interest in visual processing will also be considered.

Candidates for the theoretical position should have strong quantitative and programming skills, ideally (but not necessarily) with experience in computational neuroscience and probabilistic modeling.

Salary will be commensurate with experience according to the current NIH scale. Please send curriculum vitae, statement of research interests, up to three reprints, and a minimum of two letters of recommendation to either richard_born@hms.harvard.edu or rhaefne2@ur.rochester.edu.

Harvard Medical School and University of Rochester are Affirmative Action/Equal Opportunity Employers. Applications from minorities and women are especially encouraged.

 

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Drugowitsch Lab at Harvard Medical School
We are looking for a highly creative and motivated postdoctoral fellow to work in the field of computational and systems neuroscience in the group of Jan Drugowitsch - Department of Neurobiology at Harvard Medical School. The group works on questions of decision-making and navigation under uncertainty, ranging from the level of neural populations to that of behavior. In the short term, the postdoctoral fellow is expected to design and analyze behavioral and neural models of decision-making that are gauged against data from human subjects, collected by the laboratory of Dr. Wyart at École Normale Supérieure, Paris. In the long term, close interaction and collaboration with other members of the department is anticipated.

Candidates should have a strong analytical background, such as in computational neuroscience, physics, mathematics, engineering, or related, and feature an interest in the role of computation in neural populations and in theoretical neuroscience in general. Experience or familiarity with related machine-learning fields is also desirable. Previous experience should include sufficient programming skills to run numerical simulations, Bayesian methods, and expertise in the analysis of dynamical systems.
The position starts in or after April 2018, and is funded for several years, with an initial one-year appointment and expectation of extension given satisfactory performance. Salary depends on experience and is at levels above the NIH scale. More info
HERE.
Candidates should send a single PDF file, consisting of a 1-page motivation letter, CV, and publication list to jan_drugowitsch@hms.harvard.edu. Furthermore, candidates should organize two letters of reference, to be sent to the same e-mail address. The position is open until filled (posted on this site: 2.22.18).

Gu Laboratory at Harvard Medical School
A postdoctoral position is available to study the coordinate development of nervous and vascular systems using mouse genetics, biochemistry, imaging, and in vitro assays. Applicants should be accomplished in biochemistry, molecular biology, cell biology. Experience in the biochemical and functional characterization of proteins in the signaling pathways would be especially desirable.
 Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
 Chenghua Gu, D.V.M., & Ph.D
Department of Neurobiology
Harvard Medical School
Email: chenghua_gu@hms.harvard.edu
HMS Dept. of Neurobiology Website: http://neuro.med.harvard.edu/

Kaeser Lab at Harvard Medical School
The Kaeser lab in the Department of Neurobiology at Harvard Medical School is seeking postdoctoral fellows to study architecture, functions and diversity of presynaptic neurotransmitter release sites. We are deeply invested into dissecting the molecular machines called active zones that mediate the release of fast neurotransmitters, for example glutamate, and of neuromodulators, for example dopamine. We further study how active zone composition is modulated by activity and how cell-type or synapse specific active zone architecture modulates circuit function. We use a variety of techniques (mouse genetics, protein biochemistry, electrophysiology, optogenetics, functional imaging, superresolution and electron microscopy) to study how active zones assemble and operate. Training in neuroscience and experience in any of these techniques is desirable, but not mandatory. We offer an excellent environment to use a multidisciplinary approach for addressing fundamental secretory mechanisms in a collaborative atmosphere.
Please email a cover letter, a curriculum vitae, and names & email addresses of three references to:
Dr. Pascal Kaeser
Department of Neurobiology
Harvard Medical School
220 Longwood Ave.
Armenise 305
Boston, MA 02115

Email: kaeser@hms.harvard.edu
Website: http://kaeser.hms.harvard.edu

Pecot Lab at Harvard Medical School
The Pecot Lab in the Department of Neurobiology at Harvard Medical School is seeking postdoctoral researchers interested in studying the molecular basis of precise neural connectivity. The goal of our research is to identify general molecular and cellular principles that underlie how neural networks are assembled. We address this at the level of identified cell types and synapses in the fly visual system. We are interested in the molecules that underlie how neurons distinguish each other and form synapses with appropriate partners, and in determining the gene regulatory networks that give rise to the expression of these genes in specific cell types. We employ a diverse experimental approach, involving molecular genetics, transcriptome profiling, genomics, confocal and superresolution microscopy, calcium imaging, and electron microscopy. Training in neuroscience or fly genetics is welcome but not necessary. We offer a supportive, collaborative and creative environment. 
Please email a cover letter, a curriculum vitae, and names & email addresses of three references to:
Matthew Y. Pecot, Ph.D.
Department of Neurobiology
Harvard Medical School
Armenise 203
Boston, MA 02115
Email:
matthew_pecot@hms.harvard.edu
Website: www.pecotlab.com


Weitz Laboratory at Harvard Medical School
A postdoctoral position is available for cryo-EM analysis of protein complexes comprising the core of the mammalian circadian clock, a molecular oscillator present in all or nearly all cells that drives daily rhythms of physiology and behavior. Applicants should be accomplished in biochemistry and structural biology. Expertise in cryo-EM structure determination would be especially desirable. We have made progress in single-particle analysis of native circadian clock complexes purified from mouse tissues, and we aim to obtain high-resolution structures.
Please send a cover letter, curriculum vitae, and the names, telephone numbers, and email addresses of three references to:
Charles J. Weitz, M.D., Ph.D.
Department of Neurobiology
Harvard Medical School
Email: cweitz@hms.harvard.edu

Some recent papers:
1. Duong HA, Robles MS, Knutti K, Weitz CJ. A molecular mechanism for circadian clock negative feedback. Science 2011; 332: 1436-9.
2. Padmanabhan K, Robles MS, Westerling T, Weitz CJ. Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science 2012; 337: 599-602.
3. Kim JY, Kwak PB, Weitz CJ. Specificity in circadian clock feedback from targeted reconstitution of the NuRD co-repressor. Molecular Cell 2014; 56: 738-748.
4. Tamayo AG, Duong HA, Robles MS, Mann M, Weitz CJ. Histone mono-ubiquitination by Clock–Bmal1 complex marks Per1 and Per2 genes for circadian feedback. Nature Structural & Molecular Biology 2015; 22: 759-766.
5. Aryal RP, Kwak PB, Tamayo AG, Chiu PL, Walz T, Weitz CJ. Macromolecular assemblies of the mammalian circadian clock. Molecular Cell 2017 (in press).


Goodrich Laboratory at Harvard Medical School
The Goodrich lab is seeking a postdoctoral fellow to study the development of neural circuits in the auditory system. We use mouse genetics to understand how changes in the circuits of the inner ear affect an animal’s ability to detect and perceive sound. Projects employ a variety of techniques, including biochemical analysis of novel proteins, in vitro culturing of inner ear neurons, imaging of single cells during auditory circuit assembly, and gene expression profiling of wild-type and mutant cells. No experience with the auditory system is required, but a familiarity with neuroscience or mouse genetics is a plus. Individuals with expertise in cell biology, imaging, microarrays, or signal transduction are particularly encouraged to apply.

Please send a cover letter, CV, and three references to:
Dr. Lisa Goodrich

Dept of Neurobiology, Harvard Medical School
220 Longwood Avenue
Goldenson 442
Boston, MA 02115
Email: Lisa_Goodrich@hms.harvard.edu

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SYSTEMS BIOLOGY


Higgins Laboratory at Harvard Medical School (updated posting 3.12.19)
Research Area:  Mechanistic Mathematical Modeling of Human Disease Processes with Clinical Data

Description:  The Higgins Laboratory (Department of Systems Biology) has an opening for a postdoctoral fellow to study in vivo human blood cell population dynamics, characterizing rates of immunologic and hematologic processes and their fluctuations during times of health as well as when perturbed by diseases including infection, cancer, and diabetes, both acutely and chronically. 

Qualified applicants will have extensive knowledge of and interest in human pathophysiology, dynamical systems, numerical methods, and good software engineering practices.  For example, strong candidates would be able to compare and contrast the following:  finite elements and finite differences, lymphocyte and myelocyte, quicksort and bubble sort.  Applicants should have a Ph.D. and/or M.D. degree or be in the final year of their doctoral studies, and at least a strong undergraduate background in math, computer science, and engineering.  Interested individuals should apply by submitting an updated CV, complete contact information for three references, and a cover letter describing past research experience, research interests, and career goals.

The Marks lab, Department of Systems Biology -  Assistant Research Director  (posted 3.8.19)
Job Description:
The Marks lab in the Department of Systems Biology at Harvard Medical School is recruiting an Assistant Research Director to work closely with the PI Debora Marks in supporting exciting new projects that develop machine-learning methods for applications in neurodegeneration, synthetic biology and drug design. The individual in this role will take the lead in project management, partnering with Dr. Marks to recruit and mentor graduate students and postdoctoral fellows, manage the collaborative projects, assist with the writing of grants, progress reports, and research papers.
Preferred Qualifications:
The successful candidate will have a PhD and is likely to have research experience in experimental biology or computational biology. The position requires a sophisticated understanding of molecular biology, and superb organizational skills. Familiarity with the development and maintenance of software and servers and coding experience are advantageous but not strictly required. Strong communication and writing skills are vital, and finalists may be required to demonstrate their writing and/or editing skills. To apply, please submit a cover letter and CV . In the Subject line of your email, please write: Assistant Lab Research Director. Please note that this position is classified in the Harvard system as a Research Associate.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.
Job Type: Full-time
Education: Doctorate (Preferred)
Work authorization: United States (Required)
https://www.indeed.com/jobs?q=lab%20director&l=Boston%2C%20MA&advn=3746778855682588&vjk=f348a094a2439ce9

Associate Lab Director, Harvard Medical School, Paulsson Lab (posted 3.8.19)
Job Description:

The Paulsson lab in the Department of Systems Biology at Harvard Medical School is recruiting an Associate Research Director. This position works in partnership with the PI (Johan Paulsson) to lead several challenging and exciting projects at the interface of bacterial physiology and biophysics. We are looking for a broadly trained bacterial geneticist excited about fundamental mechanisms as well as method development. The position involves three major activities: making intellectual contributions on projects related to bacterial genetics, physiology and evolution; managing a small team of technical staff to engineer proteins and circuits at the level of deep mutational scans and complex synthetic circuits; and serving as a scientific project manager for grant submissions and reports. The Associate Lab Director will be a key intellectual partner and collaborator for many lab members, and recognized as an author on publications and patents whenever appropriate.
Preferred Qualifications:
A PhD in a biology-related field is required, with extensive and in-depth experience in bacterial genetics and physiology, preferably E. coli. Postdoctoral experience is preferred. Scientific rigor and attention to detail are essential, and creativity and an ability to see the bigger picture are a great plus. This is a high-energy and highly interactive position where excellent personal skills, including a sense of humor, are vital. Strong writing skills are also key. The academic title for this position is Research Associate.To apply, please submit a cover letter and CV. We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.
Job Type: Full-time
Education: Doctorate (Preferred)
Work authorization: United States (Required)https://www.indeed.com/jobs?q=associate lab director&l=Boston%2C MA&advn=3746778855682588&vjk=a55cce0a334a5768 

Paulsson Lab - Research Specialist - Harvard Medical School (posted 9.11.18)
Job Description: The Paulsson lab in the Department of Systems Biology at Harvard Medical School is recruiting a Research Specialist to work in partnership with the PI (Johan Paulsson) to manage a wide range of challenging and exciting projects at the interface of bacterial physiology and biophysics. We are looking for a broadly trained bacterial geneticist excited about fundamental mechanisms as well as method development. The position involves three major activities: intellectual contributions on a wide range of projects related to bacterial genetics, physiology and evolution; managing a small team of technical staff to engineer proteins and circuits at the level of deep mutational scans and complex synthetic circuits; and serving as a scientific project manager for grant submissions and reports. The Research Specialist is expected to be a key intellectual partner and collaborator for many lab members, and will be recognized as an author on publications and patents whenever appropriate. 

Preferred Qualifications: 
A PhD in a biology-related field is required, with extensive and in-depth experiences in bacterial genetics and physiology, preferably E. coli but experience with other bacterial  species would also be valued. Scientific rigor and great attention to detail are essential, and creativity and an ability to see the bigger picture are a great plus. This is a high-energy and highly interactive position, where so excellent personal skills, including a sense of humor, are vital. SVery strong writing skills are also key. To apply, please submit a cover letter and CV to Johan_Paulsson_Office@hms.harvard.edu. Please note that this position is classified in the Harvard system as a Research Associate.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.


Mootha Laboratory at Harvard Medical School
The Mootha laboratory (Department of Systems Biology) has a funded opportunity for a postdoctoral scientist in computational genetics.
The laboratory focuses on mitochondrial biology and disease and consists of a lively group of computational biologists, experimental biochemists, and physician-scientists. We are currently seeking a postdoctoral scientist to work at the interface of human genetics and systems biology, with the goal of analyzing very large scale human genome sequence datasets using network models of mitochondria derived from cellular and biochemical studies, to address questions spanning disease, epistasis, and evolution.
 Applicants should possess a Ph.D. and/or M.D. degree in computational biology, preferably with a proven track record in computational genetics and analysis of next-generation sequencing data. Interested individuals should send a cover letter, curriculum vitae, and the names/phone numbers of three people who could provide letters of reference by email to vamsi@hms.harvard.edu.
 For additional information please visit our webpage: http://mootha.hms.harvard.edu/


Fontana Laboratory at Harvard Medical School
The Fontana Laboratory is seeking two outstanding post-docs to accomplish in collaboration with other groups a prototype end-to-end pipeline that extracts detailed mechanistic information about protein-protein interactions from databases and text, assembles such information into executable reference models for the purpose of understanding their dynamical behavior and assessing the current knowledge base in specific cell signaling systems. A can-do attitude, hacker soul, originality coupled to team spirit, fearlessness, and dedicated work ethic are necessary characteristics. Pay is commensurate to experience.
 Position 1: Computer science / AI / bioinformatics / databases
The ideal candidate combines an interest, and possibly expertise, in Artificial Intelligence (text extraction, natural language processing, reasoning) with bioinformatic skills. The individual will collaborate with other groups in excavating information about molecular interactions from extant databases and text; organizing such information for translation into a formal and executable format from which models of cellular signaling are constructed. The candidate should be capable of scripting in Python or Perl, be familiar with procedural and functional programming paradigms (e.g. Java or similar and OCaml or similar) and have database experience.
Position 2: Modeler / cellular signaling / cancer pathways
The ideal candidate is a computational biologist with experience in modeling dynamical systems. The individual is a skilled programmer (C, C++ or similar, experience with OCaml a plus) who will work with Kappa, a formal agent-based modeling language (https://github.com/jkrivine/KaSim) and associated tools. Ease with formal / mathematical thinking is required. A sound instinct for molecular biology coupled to a physics mindset is highly desirable. The position functions as a modeling keystone within an ambitious project seeking to build large dynamic “reference models" of cell signaling networks involved in RAS-related cancers. Models of such networks are assembled using mechanistic knowledge extracted from databases and texts in collaboration with outside groups providing pertinent expertise.

To apply, send CV and a covering letter to Walter Fontana: walter@hms.harvard.edu.


Megason Laboratory at Harvard Medical School
A postdoctoral research fellow position is available in the Megason lab in the Department of Systems Biology at Harvard Medical School in the areas of embryology, genetics, imaging, and systems biology. The Megason Lab has initiated a project to generate a Digital Fish which is a computer recreation of how the genome is executed to turn an egg into an embryo. We combine novel imaging technologies called in toto imaging to extract quantitative molecular and cellular data from living, developing zebrafish embryos for use in modeling. In toto imaging uses confocal and 2-photon microscopy to image and track every cell in developmental processes to reconstruct complete digital cell lineages. We also are developing a novel genetic approach called FlipTraps which generate endogenously expressed fluorescent fusion proteins and Cre condtional alleles. We combine these approaches to generate quantitative models of how systems of molecules program cells and systems of cells program tissues. Additionally, we are particularly interested in applicants with experience, expertise, and interest in home built 2-photon microscopy systems. For more information please contact Sean Megason (megason@hms.harvard.edu) or visit our website www.digitalfish.org.

A cover letter detailing your research motivations and a curriculum vitae should be sent by email to the above address together with the names of three referees with contact information.

Sean Megason, PhD
Department of Systems Biology
Harvard Medical School
200 Longwood Avenue, WAB 536
Boston, MA 02115


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HARVARD SCHOOL OF DENTAL MEDICINE 

YANG LAB

A post-doctoral position is available immediately in the Yang lab based in the Department of Developmental Biology at the Harvard School of Dental Medicine.

The laboratory of Dr. Yingzi Yang has a longstanding and intense interest in defining the functional mechanisms of Wnt, Hippo, and Hedgehog signaling pathways in development and disease pathogenesis including cancer. One of our recent projects is understanding metabolism and tumor microenvironment in liver hepatocyte carcinoma (HCC) progression. This study is being pursued through the generation and analyses of genetically engineered mice, in vitro studies with cell biology and biochemistry approaches as well as corroborative studies using human specimens. This work also involves cutting-edge imaging techniques and liver tumorigenesis in vitro and in vivo models. Protein chemistry and engineering is a plus. The position is funded by NCI.

The candidate should have a PhD degree in biomedical sciences with less than 3 years of postdoctoral experience and a proven record of scientific productivity. Basic skills in molecular, genetic and cell biology are required. Duties and responsibilities of the successful candidate will include:

• strong abilities to work independently and with self-initiative;

• abilities to vigorously pursue scientific projects, both conceptually and experimentally, with pro-active thinking and action;

• collaboration with other research staff, supervision and training of lab members;

• writing and editing of manuscripts, research presentations at departmental seminars and scientific meetings.

Salary will follow NIH and university guidelines.
To apply, please send a brief statement of research interests, CV and contact information of three references to:
Yingzi Yang, PhD
Yingzi_yang@hsdm.harvard.edu
(posted 6/7/18)

IONESCU LAB
A postdoctoral fellow position (or visiting research scholar) is available in the laboratory of Dr. Andreia Ionescu at Harvard School of Dental Medicine in Boston. We are seeking Postdoctoral candidates who are independent, highly motivated and career-oriented to work on NIH-funded projects in the areas of skeletal development and disease. The successful candidate will be involved in cartilage and bone regeneration projects.

Potential candidates should have experience working with histology, molecular biology, tissue culture techniques, and mouse models. A strong background in stem cell biology will receive higher priority. Expertise in Rna-seq and ChIP-seq is desirable. Prior experience with Laser Capture Microscopy is a plus.

To apply, send your CV and email addresses of three references to: 
Dr. Andreia Ionescu, PhD
Dept. of Developmental Biology, Harvard School of Dental Medicine
188 Longwood Ave, Boston, MA 02115. Tel: 617-432-5912
Email:
Andreia_Ionescu@hms.harvard.edu
(posted 10.23.18)

 

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WYSS INSTITUTE (Department job site)

Postdoctoral Fellows Positions at the Wyss Institute for Biologically Inspired Engineering
The Wyss (pronounced "Veese") Institute for Biologically Inspired Engineering uses Nature's design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world.
 Working as an alliance among Harvard's Schools of Medicine, Engineering, and Arts & Sciences, and in partnership with Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Dana Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Tufts University, and Boston University, the Institute crosses disciplinary and institutional barriers to engage in high-risk research that leads to transformative technological breakthroughs.
 
Visit the Wyss Institute's website to find out positions available: http://wyss.harvard.edu/viewpage/191/postdoctoral-positions

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